PDGFRB Monoclonal Antibody (R.140.4) | Invitrogen MA5-14851 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PDGFRB Monoclonal Antibody (R.140.4)

catalog :

MA5-14851

quantity :

100 uL

price :

US 524.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

R.140.4

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Aye J, Stafman L, Williams A, Garner E, Stewart J, Anderson J, et al. The effects of focal adhesion kinase and platelet-derived growth factor receptor beta inhibition in a patient-derived xenograft model of primary and metastatic Wilms tumor. Oncotarget. 2019;10:5534-5548 pubmed publisher

product information

Product Type :

Antibody

Product Name :

PDGFRB Monoclonal Antibody (R.140.4)

Catalog # :

MA5-14851

Quantity :

100 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1:200-1:800, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Clone :

R.140.4

Isotype :

IgG

Storage :

-20 C

Description :

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Immunogen :

GST fusion protein containing a carboxyl-terminal fragment of human PDGF receptor ß

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:200-1:800, Western Blot: 1:1,000

Aliases :

AI528809; Beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; CD140b antigen; IBGC4; IMF1; JTK12; KOGS; PDGF beta chain; PDGF Receptor beta; Pdgfr; Pdgfr1; PDGFR-1; PDGFRB; PDGF-R-beta; PDGFR-beta; PENTT; platelet derived growth factor receptor beta; platelet derived growth factor receptor, beta polypeptide; platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide