EEA1 Monoclonal Antibody (F.43.1) | Invitrogen MA5-14794 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

EEA1 Monoclonal Antibody (F.43.1)

catalog :

MA5-14794

quantity :

100 uL

price :

US 558.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

F.43.1

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 12

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:100; loading ...; fig 6e	Daniloski Z, Jordan T, Wessels H, Hoagland D, Kasela S, Legut M, et al. Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. Cell. 2021;184:92-105.e16 pubmed publisher
immunohistochemistry; mouse; 1:1000; loading ...; fig 5c western blot; mouse; loading ...; fig 6a	Lucitti J, Sealock R, Buckley B, Zhang H, Xiao L, Dudley A, et al. Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation in the Collateral Circulation and Severity of Stroke. Stroke. 2016;47:3022-3031 pubmed
immunocytochemistry; human; fig 2	Kuramoto K, Wang N, Fan Y, Zhang W, Schoenen F, Frankowski K, et al. Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids. Autophagy. 2016;12:1460-71 pubmed publisher
immunocytochemistry; dogs; 1:200	Labilloy A, Youker R, Bruns J, Kukic I, Kiselyov K, Halfter W, et al. Altered dynamics of a lipid raft associated protein in a kidney model of Fabry disease. Mol Genet Metab. 2014;111:184-92 pubmed publisher
	Xie Y, Naseri N, Fels J, Kharel P, Na Y, Lane D, et al. Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models. Nat Commun. 2022;13:4918 pubmed publisher
	Moya E, Lombardo S, Vandenhaute E, Schneider M, Mysiorek C, T xfc reli A, et al. Interaction of surfactant coated PLGA nanoparticles with in vitro human brain-like endothelial cells. Int J Pharm. 2022;621:121780 pubmed publisher
	Sabino C, Bender D, Herrlein M, Hildt E. The Epidermal Growth Factor Receptor Is a Relevant Host Factor in the Early Stages of The Zika Virus Life Cycle In Vitro. J Virol. 2021;95:e0119521 pubmed publisher
	Han S, Choi J, Ryu K. Stress Response of Mouse Embryonic Fibroblasts Exposed to Polystyrene Nanoplastics. Int J Mol Sci. 2021;22: pubmed publisher
	Kim Y, Kong Q, Yamamoto S, Kuramoto K, Huang M, Wang N, et al. An autophagy-related protein Becn2 regulates cocaine reward behaviors in the dopaminergic system. Sci Adv. 2021;7: pubmed publisher
	Dragotakes Q, Stouffer K, Fu M, Sella Y, Youn C, Yoon O, et al. Macrophages use a bet-hedging strategy for antimicrobial activity in phagolysosomal acidification. J Clin Invest. 2020;130:3805-3819 pubmed publisher
	Nagarajan U, Tripathy M, Kollipara A, Allen J, Goodwin A, Whittimore J, et al. Differential signaling pathways are initiated in macrophages during infection depending on the intracellular fate of Chlamydia spp. Immunol Cell Biol. 2018;96:246-256 pubmed publisher
	Li Y, Zhang Y, Xu Y, Kittredge A, Ward N, Chen S, et al. Patient-specific mutations impair BESTROPHIN1's essential role in mediating Ca2+-dependent Cl- currents in human RPE. elife. 2017;6: pubmed publisher

product information

Product Type :

Antibody

Product Name :

EEA1 Monoclonal Antibody (F.43.1)

Catalog # :

MA5-14794

Quantity :

100 uL

Price :

US 558.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:50-1:200, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Clone :

F.43.1

Isotype :

IgG

Storage :

-20 C

Description :

Early endosomal antigen 1 (EEA1) is a 162 kDa membrane bound protein component specific to the early endosome and is essential for fusion between early endocytic vesicles. Early endosomes are cytoplasmic compartments which fuse with endocytic vesicles for redistribution of extracellular compounds to alternate destinations. Zinc-finger-like domains, reminiscent of those found in nucleic acid binding proteins, are located in the amino and carboxyl-terminal domains of EEA1. The carboxyl-terminal zinc-finger-like-domain is conserved in several other non-nuclear proteins, some of which are also involved in intracellular protein trafficking. In addition, this domain is an authentic zinc-binding domain and is critical to the intracellular localization of EEA1. Membrane association of EEA1 has been shown dependent on phosphatidyl 3-kinase activity, inhibitors of which cause EEA1 to dissociate from early endosomes.

Immunogen :

Synthetic peptide corresponding to residues surrounding Ser70 of human EEA1 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50-1:200, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Aliases :

A430109M19Rik; B230358H09Rik; Early endosome antigen 1; early endosome antigen 1, 162kD; early endosome-associated protein; EEA1; Endosome-associated protein p162; MST105; MSTP105; ZFYVE2; Zinc finger FYVE domain-containing protein 2

more info or order :

Invitrogen product webpage