Perlecan Monoclonal Antibody (A7L6) | Invitrogen MA5-14641 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Perlecan Monoclonal Antibody (A7L6)

catalog :

MA5-14641

quantity :

500 µL

price :

US 450.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

A7L6

reactivity :

human, mouse, dogs, bovine, pigs

application :

immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 14

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; dogs; 1:1000; loading ...; fig s6a	Amoasii L, Hildyard J, Li H, Sanchez Ortiz E, Mireault A, Caballero D, et al. Gene editing restores dystrophin expression in a canine model of Duchenne muscular dystrophy. Science. 2018;362:86-91 pubmed publisher
immunohistochemistry; mouse; 1:100; fig S1G	Fantauzzo K, Soriano P. PDGFR? regulates craniofacial development through homodimers and functional heterodimers with PDGFR?. Genes Dev. 2016;30:2443-2458 pubmed
immunohistochemistry; mouse; 1:200	Cogger V, Svistounov D, Warren A, Zykova S, Melvin R, Solon Biet S, et al. Liver aging and pseudocapillarization in a Werner syndrome mouse model. J Gerontol A Biol Sci Med Sci. 2014;69:1076-86 pubmed publisher
immunohistochemistry; human	Goddeeris M, Wu B, Venzke D, Yoshida Moriguchi T, Saito F, Matsumura K, et al. LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy. Nature. 2013;503:136-40 pubmed publisher
immunohistochemistry - frozen section; mouse; fig 3	Krishnan M, Wang C, Marion T. Anti-DNA autoantibodies initiate experimental lupus nephritis by binding directly to the glomerular basement membrane in mice. Kidney Int. 2012;82:184-92 pubmed publisher
immunohistochemistry; mouse	Nguyen A, Xiao B, Neppl R, Kallin E, Li J, Chen T, et al. DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 2011;25:263-74 pubmed publisher
immunohistochemistry; bovine	Nigro J, White J, Ramshaw J, Haylock D, Nilsson S, Werkmeister J. The effect of bovine endosteum-derived particles on the proliferation of human mesenchymal stem cells. Biomaterials. 2010;31:5689-99 pubmed publisher
immunohistochemistry; mouse	Beiting D, Park P, Appleton J. Synthesis of syndecan-1 by skeletal muscle cells is an early response to infection with Trichinella spiralis but is not essential for nurse cell development. Infect Immun. 2006;74:1941-3 pubmed
	Hildyard J, Rawson F, Wells D, Piercy R. Multiplex in situ hybridization within a single transcript: RNAscope reveals dystrophin mRNA dynamics. PLoS ONE. 2020;15:e0239467 pubmed publisher
	Chang J, Buechler M, Gressier E, Turley S, Carroll M. Mechanosensing by Peyer's patch stroma regulates lymphocyte migration and mucosal antibody responses. Nat Immunol. 2019;20:1506-1516 pubmed publisher
	Saw S, Aiken A, Fang H, McKee T, Bregant S, Sanchez O, et al. Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth. J Cell Biol. 2019;218:3134-3152 pubmed publisher
	Price E, Carnazza K, Carlin S, Cho A, Edwards K, Sevak K, et al. 89Zr-DFO-AMG102 Immuno-PET to Determine Local Hepatocyte Growth Factor Protein Levels in Tumors for Enhanced Patient Selection. J Nucl Med. 2017;58:1386-1394 pubmed publisher
	de Greef J, Hamlyn R, Jensen B, O Campo Landa R, Levy J, Kobuke K, et al. Collagen VI deficiency reduces muscle pathology, but does not improve muscle function, in the Î³-sarcoglycan-null mouse. Hum Mol Genet. 2016;25:1357-69 pubmed publisher
	Qiao D, Meyer K, Mundhenke C, Drew S, Friedl A. Heparan sulfate proteoglycans as regulators of fibroblast growth factor-2 signaling in brain endothelial cells. Specific role for glypican-1 in glioma angiogenesis. J Biol Chem. 2003;278:16045-53 pubmed

product information

Product Type :

Antibody

Product Name :

Perlecan Monoclonal Antibody (A7L6)

Catalog # :

MA5-14641

Quantity :

500 µL

Price :

US 450.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Bovine, Human, Mouse, Porcine

Applications :

Immunohistochemistry (Frozen): 1:20, Immunohistochemistry (Paraffin): 1:20

Species :

Bovine, Human, Mouse, Porcine

Clone :

A7L6

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

Immunogen :

Murine EHS laminin preparation

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Frozen): 1:20, Immunohistochemistry (Paraffin): 1:20

Aliases :

AI852380; Basement membrane-specific heparan sulfate proteoglycan core protein; Endorepellin; endorepellin (domain V region); heparan sulfate proteoglycan 2; HSPG; Hspg2; LG3 peptide; LOC313641; Pcn; per; perlecan; perlecan (heparan sulfate proteoglycan 2); perlecan proteoglycan; PLC; PRCAN; RP11-132G19.2; SJA; SJS; SJS1