VDR Monoclonal Antibody (9A7gamma.E10.E4), Biotin | Invitrogen MA5-14614 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

VDR Monoclonal Antibody (9A7gamma.E10.E4), Biotin

catalog :

MA5-14614

quantity :

500 µL

price :

US 496

clonality :

monoclonal

host :

rat

conjugate :

biotin

clone name :

9A7gamma.E10.E4

reactivity :

Chinese hamsters, human, mouse, rat, chicken, pigs

application :

western blot

citations: 7

Reference
Schnatz P, Nudy M, O Sullivan D, Jiang X, Cline J, Kaplan J, et al. Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D: their association with atherosclerosis. Menopause. 2012;19:967-73 pubmed
Sidler Lauff K, Boos A, Kraenzlin M, Liesegang A. Influence of different calcium supplies and a single vitamin D injection on vitamin D receptor and calbindin D9k immunoreactivities in the gastrointestinal tract of goat kids. J Anim Sci. 2010;88:3598-610 pubmed publisher
Lange T, Zou Y, Singh R, Kim K, Kristjansdottir K, Sholler G, et al. Chemotherapeutic effect of calcidiol derivative B3CD in a neuroblastoma xenograft model. Chem Biol Drug Des. 2010;76:164-73 pubmed publisher
Alimirah F, Vaishnav A, McCormick M, Echchgadda I, Chatterjee B, Mehta R, et al. Functionality of unliganded VDR in breast cancer cells: repressive action on CYP24 basal transcription. Mol Cell Biochem. 2010;342:143-50 pubmed publisher
Sahin M, Canda A, Yorukoglu K, Mungan M, Sade M, Kirkali Z. 1,25 Dihydroxyvitamin D(3) receptor expression in superficial transitional cell carcinoma of the bladder: a possible prognostic factor?. Eur Urol. 2005;47:52-7 pubmed
Narvaez C, Byrne B, Romu S, Valrance M, Welsh J. Induction of apoptosis by 1,25-dihydroxyvitamin D3 in MCF-7 Vitamin D3-resistant variant can be sensitized by TPA. J Steroid Biochem Mol Biol. 2003;84:199-209 pubmed
Zinser G, McEleney K, Welsh J. Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice. Mol Cell Endocrinol. 2003;200:67-80 pubmed

product information

Product Type :

Antibody

Product Name :

VDR Monoclonal Antibody (9A7gamma.E10.E4), Biotin

Catalog # :

MA5-14614

Quantity :

500 µL

Price :

US 496

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Amphibian, Chicken, Fish, Hamster, Human, Mouse, Porcine, Rat

Applications :

Gel Shift: 1mg/mL, Western Blot: 1-2 µg/mL

Species :

Amphibian, Chicken, Fish, Hamster, Human, Mouse, Porcine, Rat

Clone :

9A7gamma.E10.E4

Isotype :

IgG2b

Storage :

4° C

Description :

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expression, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. The corresponding gene for the vitamin D receptor is NR1I1.

Immunogen :

Vitamin D receptor protein from chicken intestine

Format :

Liquid

Applications w/Dilutions :

Gel Shift: 1mg/mL, Western Blot: 1-2 µg/mL

Aliases :

1,25-dihydroxyvitamin D3 receptor; HGNC:12679; I79_025795; NR1I1; Nuclear receptor subfamily 1 group I member 1; PPP1R163; protein phosphatase 1, regulatory subunit 163; VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor; vitamin D (1,25-dihydroxyvitamin D3) receptor; vitamin D nuclear receptor variant 1; vitamin D receptor; Vitamin D3 receptor