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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Synaptophysin Monoclonal Antibody (SP11)
catalog :
MA5-14532
quantity :
500 uL
price :
US 470.00
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
SP11
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 69
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; 1:250; fig s3
Campagno K, Lu W, Jassim A, Albalawi F, Cenaj A, Tso H, et al. Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure. J Neuroinflammation. 2021;18:217 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s15c, s15d
Xu Z, Kim G, Tan J, Riso A, Sun Y, Xu E, et al. Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations. Nat Commun. 2020;11:1797 pubmed publisher
  • immunohistochemistry; rat; 1:500; loading ...; fig 6d
McCann M, Fisher K, Ahloy Dallaire J, Darian Smith C. Somatosensory corticospinal tract axons sprout within the cervical cord following a dorsal root/dorsal column spinal injury in the rat. J Comp Neurol. 2019;: pubmed publisher
  • immunohistochemistry; human; loading ...; fig 4d
De Luca Johnson J, Zenali M. A Previously Undescribed Presentation of Mixed Adenoneuroendocrine Carcinoma. Case Rep Pathol. 2016;2016:9063634 pubmed
  • immunohistochemistry - paraffin section; human; 1:50; loading ...
George J, Saito M, Tsuta K, Iwakawa R, Shiraishi K, Scheel A, et al. Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer. Clin Cancer Res. 2017;23:1220-1226 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; tbl 3
  • immunohistochemistry - frozen section; human; 1:50; tbl 3
Bahia El Idrissi N, Bosch S, Ramaglia V, Aronica E, Baas F, Troost D. Complement activation at the motor end-plates in amyotrophic lateral sclerosis. J Neuroinflammation. 2016;13:72 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 3
Choi S, Chen Z, Tang L, Fang Y, Shin S, Panarelli N, et al. Bcl-xL promotes metastasis independent of its anti-apoptotic activity. Nat Commun. 2016;7:10384 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; fig 1
Böger C, Haag J, Egberts J, Röcken C. Complex APC germline mutation associated metaplasia and intraepithelial neoplasia (CAM-IEN) of the gallbladder. Pathol Res Pract. 2016;212:54-8 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Projetti F, Serrano E, Vergez S, Bissainthe A, Delisle M, Uro Coste E. Is neuroendocrine differentiation useful to discriminate primary sinonasal intestinal-type adenocarcinomas from metastatic colorectal adenocarcinomas?. J Clin Pathol. 2015;68:79-82 pubmed publisher
  • immunohistochemistry; human; 1:100; fig s1
Hijioka S, Hosoda W, Mizuno N, Hara K, Imaoka H, Bhatia V, et al. Does the WHO 2010 classification of pancreatic neuroendocrine neoplasms accurately characterize pancreatic neuroendocrine carcinomas?. J Gastroenterol. 2015;50:564-72 pubmed publisher
  • immunohistochemistry; human; 1:200
Milione M, Gasparini P, Sozzi G, Mazzaferro V, Ferrari A, Casali P, et al. Ewing sarcoma of the small bowel: a study of seven cases, including one with the uncommonly reported EWSR1-FEV translocation. Histopathology. 2014;64:1014-26 pubmed publisher
  • immunohistochemistry; human; 1:100
Altinay S, Kusaslan R. Gastrointestinal autonomic nerve tumour of jejunum presenting as a perforated mass. J Pak Med Assoc. 2014;64:461-4 pubmed
  • immunohistochemistry; human; 1:100
Lee J, Yu C, Kim M, Hong S, Lim S, Kim J. Prognostic impact of diagnosing colorectal neuroendocrine carcinoma using the World Health Organization 2010 classification. Surgery. 2014;155:650-8 pubmed publisher
  • immunohistochemistry; human; 1:100
Chang T, Lin H, Rogers K, Brame L, Yeh M, Yang Q, et al. Expression of aldo-keto reductase family 1 member C3 (AKR1C3) in neuroendocrine tumors & adenocarcinomas of pancreas, gastrointestinal tract, and lung. Int J Clin Exp Pathol. 2013;6:2419-29 pubmed
  • immunohistochemistry; human; 1:100
Hasegawa T, Yamao K, Hijioka S, Bhatia V, Mizuno N, Hara K, et al. Evaluation of Ki-67 index in EUS-FNA specimens for the assessment of malignancy risk in pancreatic neuroendocrine tumors. Endoscopy. 2014;46:32-8 pubmed publisher
  • immunohistochemistry; human; 1:200
Lopez F, Costales M, Vivanco B, Fresno M, Suarez C, Llorente J. Sinonasal desmoplastic small round cell tumor. Auris Nasus Larynx. 2013;40:573-6 pubmed publisher
  • immunohistochemistry; human
Thiery Lavenant G, Zavalin A, Caprioli R. Targeted multiplex imaging mass spectrometry in transmission geometry for subcellular spatial resolution. J Am Soc Mass Spectrom. 2013;24:609-14 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • immunohistochemistry; human
Mosquera J, Beltran H, Park K, MacDonald T, Robinson B, Tagawa S, et al. Concurrent AURKA and MYCN gene amplifications are harbingers of lethal treatment-related neuroendocrine prostate cancer. Neoplasia. 2013;15:1-10 pubmed
  • immunohistochemistry; human; 1:100
Masago K, Hosada W, Sasaki E, Murakami Y, Sugano M, Nagasaka T, et al. Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature. Case Rep Oncol. 2012;5:471-8 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Pan J, Yeger H, Ratcliffe P, Bishop T, Cutz E. Hyperplasia of pulmonary neuroepithelial bodies (NEB) in lungs of prolyl hydroxylase -1(PHD-1) deficient mice. Adv Exp Med Biol. 2012;758:149-55 pubmed publisher
  • immunohistochemistry; human; 1:100
Zhao L, Luo J, Zhang H, Da J. Pigmented paraganglioma of the kidney: a case report. Diagn Pathol. 2012;7:77 pubmed publisher
  • immunohistochemistry; human; 1:100
Righi L, Rapa I, Votta A, Papotti M, Sapino A. Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma. Virchows Arch. 2012;460:415-21 pubmed publisher
  • immunohistochemistry; human; 1:100
Terris B, Genevay M, Rouquette A, Audebourg A, Mentha G, Dousset B, et al. Acinar cell carcinoma: a possible diagnosis in patients without intrapancreatic tumour. Dig Liver Dis. 2011;43:971-4 pubmed publisher
  • immunohistochemistry; human
Asioli S, Righi A, de Biase D, Morandi L, Caliendo V, Picciotto F, et al. Expression of p63 is the sole independent marker of aggressiveness in localised (stage I-II) Merkel cell carcinomas. Mod Pathol. 2011;24:1451-61 pubmed publisher
  • immunohistochemistry; human; 1:100
Lee M, Cho K, Yu C, Park Y, Kim J, Kim J, et al. Perivascular epithelioid cell tumor of the sigmoid colon with transcription factor E3 expression. Ann Diagn Pathol. 2012;16:306-11 pubmed publisher
  • immunohistochemistry; mouse; 1:100
McCartney S, Vermi W, Lonardi S, Rossini C, Otero K, Calderon B, et al. RNA sensor-induced type I IFN prevents diabetes caused by a ? cell-tropic virus in mice. J Clin Invest. 2011;121:1497-507 pubmed publisher
  • immunohistochemistry; human
Eloy C, Vinagre J, Cameselle Teijeiro J, Paiva M, Soares P, Sobrinho Simoes M. Tumor-in-tumor of the thyroid with basaloid differentiation: a lesion with a solid cell nest neoplastic component?. Int J Surg Pathol. 2011;19:276-80 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig 2, 3, 4
Baydar D, Kulac I, Gurel B, De Marzo A. A case of prostatic adenocarcinoma with aberrant p63 expression: presentation with detailed immunohistochemical study and FISH analysis. Int J Surg Pathol. 2011;19:131-6 pubmed publisher
  • immunohistochemistry; human
Park S, Park C, Kim S, Jang S, Chi H, Kim M, et al. Detection of bone marrow metastases of neuroblastoma with immunohistochemical staining of CD56, chromogranin A, and synaptophysin. Appl Immunohistochem Mol Morphol. 2010;18:348-52 pubmed publisher
  • immunohistochemistry; human; 1:20
Yajima N, Mizukami H, Wada R, Saito F, Yagihashi S. Small cell carcinoma with skeletal muscle differentiation of urinary bladder. Pathol Int. 2009;59:748-51 pubmed publisher
  • immunohistochemistry; human
Mouser P, Levy M, Sojka J, Ramos Vara J. Cerebellar abiotrophy in an alpaca (Lama pacos). Vet Pathol. 2009;46:1133-7 pubmed publisher
  • immunohistochemistry; human; 1:300
Baydar D, Aydin O. Confusing cases: clear cell but not renal cell lesions in kidney. Pathol Int. 2008;58:713-7 pubmed publisher
  • immunohistochemistry; human; 1:1000
Marton E, Feletti A, Basaldella L, Dei Tos A, Bendini M, Longatti P. Atypical cystic meningioma overexpressing AQP1 in early infancy: case report with literature review. Acta Paediatr. 2008;97:1145-9 pubmed publisher
  • immunohistochemistry; human; 1:125
Buresh C, Oliai B, Miller R. Reactivity with TdT in Merkel cell carcinoma: a potential diagnostic pitfall. Am J Clin Pathol. 2008;129:894-8 pubmed publisher
  • immunohistochemistry; human; 1:400
Skalova A, Sima R, Bohus P, Curik R, Lukas J, Michal M. Endolymphatic sac tumor (aggressive papillary tumor of middle ear and temporal bone): report of two cases with analysis of the VHL gene. Pathol Res Pract. 2008;204:599-606 pubmed publisher
  • immunohistochemistry; human
Strojan Flezar M, Srebotnik Kirbis I. Identification of carcinoma origin by thyroid transcription factor-1 immunostaining of fine needle aspirates of metastases. Cytopathology. 2009;20:176-82 pubmed publisher
  • immunohistochemistry; human; 1:100
Eisenthal A, Trejo L, Shtabsky A, Bedny F, Brazowski E. A novel assessment of the quality of immunohistostaining overcomes the limitations of current methods. Pathol Res Pract. 2008;204:323-8 pubmed publisher
  • immunohistochemistry; human
Asioli S, Accinelli G, Pacchioni D, Bussolati G. Diagnosis of biliary tract lesions by histological sectioning of brush bristles as alternative to cytological smearing. Am J Gastroenterol. 2008;103:1274-81 pubmed publisher
  • immunohistochemistry; human; 1:100
Wong S, Chan J, Lo E, Chan A, Wong M, Chan C, et al. The contribution of bifunctional SkipDewax pretreatment solution, rabbit monoclonal antibodies, and polymer detection systems in immunohistochemistry. Arch Pathol Lab Med. 2007;131:1047-55 pubmed
  • immunohistochemistry; human; 1:100
Asioli S, Righi A, Volante M, Eusebi V, Bussolati G. p63 expression as a new prognostic marker in Merkel cell carcinoma. Cancer. 2007;110:640-7 pubmed
  • immunocytochemistry; mouse
Pan J, Luk C, Kent G, Cutz E, Yeger H. Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice. Am J Respir Cell Mol Biol. 2006;35:320-6 pubmed
  • immunohistochemistry; human; 1:100
Volante M, La Rosa S, Castellano I, Finzi G, Capella C, Bussolati G. Clinico-pathological features of a series of 11 oncocytic endocrine tumours of the pancreas. Virchows Arch. 2006;448:545-51 pubmed
Wang M, Yan C, Li X, Yang T, Wu S, Liu Q, et al. Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer's disease-associated pathology and cognition in mice. Nat Commun. 2024;15:1453 pubmed publisher
Saini S, Sreekumar A, Nathani S, Asante D, Simmons M. A novel exosome based therapeutic intervention against neuroendocrine prostate cancer. Sci Rep. 2024;14:2816 pubmed publisher
Baek H, Sanjay -, Park M, Lee H. Cyanidin-3-O-glucoside protects the brain and improves cognitive function in APPswe/PS1ΔE9 transgenic mice model. J Neuroinflammation. 2023;20:268 pubmed publisher
Korvenlaita N, G xf3 mez Budia M, Scoyni F, Pistono C, Giudice L, Eamen S, et al. Dynamic release of neuronal extracellular vesicles containing miR-21a-5p is induced by hypoxia. J Extracell Vesicles. 2023;12:e12297 pubmed publisher
Vratari x107 M, x160 enk V, Bursa x107 B, Gligorovska L, Ignjatovi x107 D, Kova x10d evi x107 S, et al. Fructose diet ameliorate effects of macrophage migration inhibitory factor deficiency on prefrontal cortex inflammation, neural plasticity, and behavior in male mice. Biofactors. 2023;49:90-107 pubmed publisher
Squizani S, Jantsch J, Rodrigues F, Braga M, Eller S, de Oliveira T, et al. Zinc Supplementation Partially Decreases the Harmful Effects of a Cafeteria Diet in Rats but Does Not Prevent Intestinal Dysbiosis. Nutrients. 2022;14: pubmed publisher
Sheu S, Upadhyayula S, Dupuy V, Pang S, Deng F, Wan J, et al. A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell. 2022;185:3390-3407.e18 pubmed publisher
Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, et al. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy. Brain. 2022;145:4368-4384 pubmed publisher
Forsythe S, Erali R, Laney P, Sivakumar H, Li W, Skardal A, et al. Application of immune enhanced organoids in modeling personalized Merkel cell carcinoma research. Sci Rep. 2022;12:13865 pubmed publisher
Liu L, Koo Y, Russell T, Yun Y. A Three-Dimensional Brain-on-a-Chip Using Human iPSC-Derived GABAergic Neurons and Astrocytes. Methods Mol Biol. 2022;2492:117-128 pubmed publisher
Hivare P, Gadhavi J, Bhatia D, Gupta S. α-Synuclein fibrils explore actin-mediated macropinocytosis for cellular entry into model neuroblastoma neurons. Traffic. 2022;23:391-410 pubmed publisher
Long X, Wu H, Zhou Y, Wan Y, Kan X, Gong J, et al. Preventive Effect of Limosilactobacillus fermentum SCHY34 on Lead Acetate-Induced Neurological Damage in SD Rats. Front Nutr. 2022;9:852012 pubmed publisher
Jiang Y, Wang Z, Liu X, Wan M, Liu Y, Jiao B, et al. The Protective Effects of Osteocyte-Derived Extracellular Vesicles Against Alzheimer's Disease Diminished with Aging. Adv Sci (Weinh). 2022;9:e2105316 pubmed publisher
Fagerlund I, Dougalis A, Shakirzyanova A, G xf3 mez Budia M, Pelkonen A, Konttinen H, et al. Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids. Cells. 2021;11: pubmed publisher
Sokolov D, Sechrest E, Wang Y, Nevin C, Du J, Kolandaivelu S. Nuclear NAD+-biosynthetic enzyme NMNAT1 facilitates development and early survival of retinal neurons. elife. 2021;10: pubmed publisher
Dwivedi S, Bautista M, Shrestha S, Elhasasna H, Chaphekar T, Vizeacoumar F, et al. Sympathetic signaling facilitates progression of neuroendocrine prostate cancer. Cell Death Discov. 2021;7:364 pubmed publisher
Chen Z, Huang Y, Yu C, Liu Q, Qiu C, Wan G. Cochlear Sox2+ Glial Cells Are Potent Progenitors for Spiral Ganglion Neuron Reprogramming Induced by Small Molecules. Front Cell Dev Biol. 2021;9:728352 pubmed publisher
Luo Y, Yang S, Wu X, Takahashi S, Sun L, Cai J, et al. Intestinal MYC modulates obesity-related metabolic dysfunction. Nat Metab. 2021;3:923-939 pubmed publisher
Bebber C, Thomas E, Stroh J, Chen Z, Androulidaki A, Schmitt A, et al. Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nat Commun. 2021;12:2048 pubmed publisher
Asgari Taei A, Dargahi L, Nasoohi S, Hassanzadeh G, Kadivar M, Farahmandfar M. The conditioned medium of human embryonic stem cell-derived mesenchymal stem cells alleviates neurological deficits and improves synaptic recovery in experimental stroke. J Cell Physiol. 2021;236:1967-1979 pubmed publisher
Liu L, Koo Y, Russell T, Gay E, Li Y, Yun Y. Three-dimensional brain-on-chip model using human iPSC-derived GABAergic neurons and astrocytes: Butyrylcholinesterase post-treatment for acute malathion exposure. PLoS ONE. 2020;15:e0230335 pubmed publisher
Shrestha A, Sultana R, Lee C, Ogundele O. SK Channel Modulates Synaptic Plasticity by Tuning CaMKIIα/β Dynamics. Front Synaptic Neurosci. 2019;11:18 pubmed publisher
Lecca D, Bader M, Tweedie D, Hoffman A, Jung Y, Hsueh S, et al. (-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice. Neurobiol Dis. 2019;130:104528 pubmed publisher
Huang M, Tailor J, Zhen Q, Gillmor A, Miller M, Weishaupt H, et al. Engineering Genetic Predisposition in Human Neuroepithelial Stem Cells Recapitulates Medulloblastoma Tumorigenesis. Cell Stem Cell. 2019;: pubmed publisher
Bagheri A, Habibzadeh P, Razavipour S, Volmar C, Chee N, Brothers S, et al. HDAC Inhibitors Induce BDNF Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons. Int J Mol Sci. 2019;20: pubmed publisher
Grill M, Hasenoehrl C, Kienzl M, Kargl J, Schicho R. Cellular localization and regulation of receptors and enzymes of the endocannabinoid system in intestinal and systemic inflammation. Histochem Cell Biol. 2019;151:5-20 pubmed publisher
Sauter J, Ambaye A, Mount S. Increased utilization, verification, and clinical implications of immunocytochemistry: Experience in a northern New England hospital. Diagn Cytopathol. 2015;43:688-95 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Synaptophysin Monoclonal Antibody (SP11)
Catalog # :
MA5-14532
Quantity :
500 uL
Price :
US 470.00
Clonality :
Monoclonal
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:200
Species :
Human, Mouse, Rat
Clone :
SP11
Isotype :
IgG
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
Synaptophysin is a calcium-binding and integral membrane glycoprotein present in presynaptic vesicles in almost all neurons. Synaptophysin has four transmembrane domains and it forms a complex with dynamin at high calcium concentrations suggesting an involvement in synaptic vesicle endocytosis. It is also involved in the regulation of short-term and long-term synaptic plasticity. Synaptophysin is currently the most widely used marker for nerve terminals and for differentiating neuroendocrine tumors. Mutations in the gene can result in mental retardation, X-linked 96.
Immunogen :
A synthetic peptide of human synaptophysin (aa 250-313).
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): 1:200, Western Blot: 1:200
Aliases :
A230093K24Rik; AI848995; BM89 antigen; I79_012252; Major synaptic vesicle protein p38; MRX96; MRXSYP; p38; Syn; Synaptophysin; Syp; Syp I; Syp1
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA