ALK Monoclonal Antibody (SP8) | Invitrogen MA5-14528 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ALK Monoclonal Antibody (SP8)

catalog :

MA5-14528

quantity :

500 uL

price :

US 552.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SP8

reactivity :

human, mouse

application :

ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
ELISA; human; loading ...; fig s3	Kourentzi K, Crum M, Patil U, Prebisch A, Chavan D, Vu B, et al. Recombinant expression, characterization, and quantification in human cancer cell lines of the Anaplastic Large-Cell Lymphoma-characteristic NPM-ALK fusion protein. Sci Rep. 2020;10:5078 pubmed publisher
immunohistochemistry; human; 1:50	Duijkers F, Gaal J, Meijerink J, Admiraal P, Pieters R, de Krijger R, et al. High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome. Am J Pathol. 2012;180:1223-31 pubmed publisher
immunohistochemistry; human; 1:100	Giuriato S, Foisseau M, Dejean E, Felsher D, Al Saati T, Demur C, et al. Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia. Blood. 2010;115:4061-70 pubmed publisher
immunohistochemistry; human	Horváth E, Mezei T, Pávai Z, Turcu M, Demian S, Toth E, et al. Diagnostic and differential diagnostic criteria of lymphoid neoplasms in bone marrow trephine biopsies: a study of 87 cases. Rom J Morphol Embryol. 2009;50:399-406 pubmed
immunohistochemistry; human; 1:100	Giuriato S, Faumont N, Bousquet E, Foisseau M, Bibonne A, Moreau M, et al. Development of a conditional bioluminescent transplant model for TPM3-ALK-induced tumorigenesis as a tool to validate ALK-dependent cancer targeted therapy. Cancer Biol Ther. 2007;6:1318-23 pubmed

product information

Product Type :

Antibody

Product Name :

ALK Monoclonal Antibody (SP8)

Catalog # :

MA5-14528

Quantity :

500 uL

Price :

US 552.00

Clonality :

Monoclonal

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100

Species :

Human, Mouse

Clone :

SP8

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily. It is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors, including anaplastic large cell lymphoma, neurblastoma, and non-small cell lung cancer. Chromosomal rearrangement is the most common genetic alteration. The translocation creates a fusion gene consisting of the ALK gene and the nucleophosmin gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK. ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system.

Immunogen :

Recombinant fragment within ALK aa 1350-1500. The exact sequence is proprietary.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100

Aliases :

Alk; ALK tyrosine kinase receptor; ALK/NPM1 fusion gene; anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; Anaplastic Lymphoma Kinase p80; anaplastic lymphoma receptor tyrosine kinase; CD246; CD246 antigen; EC 2.7.10.1; kinase ALK; mutant anaplastic lymphoma kinase; NBLST3; npm-alk; p80; Tcrz; TFG/ALK

more info or order :

Invitrogen product webpage