Progesterone Receptor Monoclonal Antibody (SP2) | Invitrogen MA5-14505 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Progesterone Receptor Monoclonal Antibody (SP2)

catalog :

MA5-14505

quantity :

500 uL

price :

US 920.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SP2

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 144

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; rat; fig 4b	Hsu C, Hsu L, Hsueh Y, Lin C, Chang H, Hsu C. Ovarian Folliculogenesis and Uterine Endometrial Receptivity after Intermittent Vaginal Injection of Recombinant Human Follicle-Stimulating Hormone in Infertile Women Receiving In Vitro Fertilization and in Immature Female Rats. Int J Mol Sci. 2021;22: pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 4c	Burgess S, Gibbs H, Toomes C, Coletta P, Bell S. The Role of Csmd1 during Mammary Gland Development. Genes (Basel). 2021;12: pubmed publisher
immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 5c	Lozzi B, Huang T, Sardar D, Huang A, Deneen B. Regionally Distinct Astrocytes Display Unique Transcription Factor Profiles in the Adult Brain. Front Neurosci. 2020;14:61 pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig 1b	Sheen M, Marotti J, Allegrezza M, Rutkowski M, Conejo Garcia J, Fiering S. Constitutively activated PI3K accelerates tumor initiation and modifies histopathology of breast cancer. Oncogenesis. 2016;5:e267 pubmed publisher
immunohistochemistry - paraffin section; human; 1:250; tbl 1	Liu Y, Wang K, Xing H, Zhai X, Wang L, Wang W. Attempt towards a novel classification of triple-negative breast cancer using immunohistochemical markers. Oncol Lett. 2016;12:1240-1256 pubmed
immunohistochemistry - paraffin section; human; 1:200; fig 4a	Choi Y, Kim H, Lim E, Park M, Yoon J, Kim Y, et al. Integrative Analyses of Uterine Transcriptome and MicroRNAome Reveal Compromised LIF-STAT3 Signaling and Progesterone Response in the Endometrium of Patients with Recurrent/Repeated Implantation Failure (RIF). PLoS ONE. 2016;11:e0157696 pubmed publisher
immunohistochemistry; human; 1:300; loading ...	Matsumoto H, Thike A, Li H, Yeong J, Koo S, Dent R, et al. Increased CD4 and CD8-positive T cell infiltrate signifies good prognosis in a subset of triple-negative breast cancer. Breast Cancer Res Treat. 2016;156:237-47 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; tbl 1	El Gendi S, Mostafa M. Runx2 Expression as a Potential Prognostic Marker in Invasive Ductal Breast Carcinoma. Pathol Oncol Res. 2016;22:461-70 pubmed publisher
immunocytochemistry; human; 1:10; fig 1b	Fridriksdottir A, Kim J, Villadsen R, Klitgaard M, Hopkinson B, Petersen O, et al. Propagation of oestrogen receptor-positive and oestrogen-responsive normal human breast cells in culture. Nat Commun. 2015;6:8786 pubmed publisher
immunohistochemistry; human; 1:1000; fig 6	Ertoy Baydar D, Kosemehmetoglu K, Aydin O, Bridge J, Buyukeren B, Aki F. Primary sclerosing epithelioid fibrosarcoma of kidney with variant histomorphologic features: report of 2 cases and review of the literature. Diagn Pathol. 2015;10:186 pubmed publisher
immunohistochemistry; human; 1:100	KapucuoÄŸlu N, Bozkurt K, BaÅŸpÄ±nar Å, KoÃ§er M, EroÄŸlu H, Akdeniz R, et al. The clinicopathological and prognostic significance of CD24, CD44, CD133, ALDH1 expressions in invasive ductal carcinoma of the breast: CD44/CD24 expression in breast cancer. Pathol Res Pract. 2015;211:740-7 pubmed publisher
western blot; mouse; 1:200	Koren S, Reavie L, Couto J, De Silva D, Stadler M, Roloff T, et al. PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours. Nature. 2015;525:114-8 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; tbl 2	Cheung S, Boey Y, Koh V, Thike A, Lim J, Iqbal J, et al. Role of epithelial-mesenchymal transition markers in triple-negative breast cancer. Breast Cancer Res Treat. 2015;152:489-98 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200	Koh V, Lim J, Thike A, Cheok P, Thu M, Tan V, et al. Characteristics and behaviour of screen-detected ductal carcinoma in situ of the breast: comparison with symptomatic patients. Breast Cancer Res Treat. 2015;152:293-304 pubmed publisher
immunohistochemistry - paraffin section; human	Nwafor C, Keshinro S. Pattern of hormone receptors and human epidermal growth factor receptor 2 status in sub-Saharan breast cancer cases: Private practice experience. Niger J Clin Pract. 2015;18:553-8 pubmed publisher
immunohistochemistry; human; 1:200	Oon M, Thike A, Tan S, Tan P. Cancer stem cell and epithelial-mesenchymal transition markers predict worse outcome in metaplastic carcinoma of the breast. Breast Cancer Res Treat. 2015;150:31-41 pubmed publisher
western blot; human; fig 3	Hole S, Pedersen A, Hansen S, Lundqvist J, Yde C, Lykkesfeldt A. New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane. Int J Oncol. 2015;46:1481-90 pubmed publisher
immunohistochemistry; human; 1:200	Liu J, Yu Y, Sun J, He S, Wang X, Yin J, et al. Clinicopathologic characteristics and prognosis of primary squamous cell carcinoma of the breast. Breast Cancer Res Treat. 2015;149:133-40 pubmed publisher
immunohistochemistry; human; 1:300	Chan A, Tong J, Sung M, Lai P, To K. Epstein-Barr virus-associated lymphoepithelioma-like cholangiocarcinoma: a rare variant of intrahepatic cholangiocarcinoma with favourable outcome. Histopathology. 2014;65:674-83 pubmed publisher
immunohistochemistry; human; 1:400	Kim E, Kim J, Lee Y, Chong G, Park J, Hong D. Comparison of estrogen receptor-?, progesterone receptor and calponin expression in gonadotrophin-releasing hormone agonist-sensitive and -resistant uterine fibroids. Obstet Gynecol Sci. 2014;57:144-50 pubmed publisher
immunocytochemistry; human; 1:25 immunohistochemistry; human; 1:25	Balk Møller E, Kim J, Hopkinson B, Timmermans Wielenga V, Petersen O, Villadsen R. A marker of endocrine receptor-positive cells, CEACAM6, is shared by two major classes of breast cancer: luminal and HER2-enriched. Am J Pathol. 2014;184:1198-208 pubmed publisher
immunohistochemistry - paraffin section; human; 1:2000	Liu Y, Nenutil R, Appleyard M, Murray K, Boylan M, Thompson A, et al. Lack of correlation of stem cell markers in breast cancer stem cells. Br J Cancer. 2014;110:2063-71 pubmed publisher
immunohistochemistry; mouse; 1:1000-10000	von Figura G, Fukuda A, Roy N, Liku M, Morris Iv J, Kim G, et al. The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma. Nat Cell Biol. 2014;16:255-67 pubmed publisher
immunohistochemistry; human	Dean S, Perks C, Holly J, Bhoo Pathy N, Looi L, Mohammed N, et al. Loss of PTEN expression is associated with IGFBP2 expression, younger age, and late stage in triple-negative breast cancer. Am J Clin Pathol. 2014;141:323-33 pubmed publisher
western blot; human; 1:2000	Kirkegaard T, Hansen S, Larsen S, Reiter B, Sørensen B, Lykkesfeldt A. T47D breast cancer cells switch from ER/HER to HER/c-Src signaling upon acquiring resistance to the antiestrogen fulvestrant. Cancer Lett. 2014;344:90-100 pubmed publisher
immunohistochemistry; mouse western blot; mouse	Goddard L, Murphy T, Org T, Enciso J, HASHIMOTO PARTYKA M, Warren C, et al. Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell. 2014;156:549-62 pubmed publisher
immunohistochemistry; human; 1:100	Abdelzaher E, El Deeb N, Gowil A, Yehya A. Biological and demographic profile of meningiomas in a cohort of Egyptian patients: impact on tumor recurrence. ScientificWorldJournal. 2013;2013:375139 pubmed publisher
immunohistochemistry - paraffin section; human immunocytochemistry; human	Dong P, Kaneuchi M, Xiong Y, Cao L, Cai M, Liu X, et al. Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer. Carcinogenesis. 2014;35:760-8 pubmed publisher
immunohistochemistry; human	Hrstka R, Brychtova V, Fabian P, Vojtesek B, Svoboda M. AGR2 predicts tamoxifen resistance in postmenopausal breast cancer patients. Dis Markers. 2013;35:207-12 pubmed publisher
western blot; mouse	Gagnidze K, Weil Z, Faustino L, Schaafsma S, Pfaff D. Early histone modifications in the ventromedial hypothalamus and preoptic area following oestradiol administration. J Neuroendocrinol. 2013;25:939-55 pubmed publisher
western blot; human; 0.32 ug/ml	Bjerre C, Vinther L, Belling K, Würtz S, Yadav R, Lademann U, et al. TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression. Tumour Biol. 2013;34:3839-51 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200; fig 2	Zhang J, Wang Y, Yin Q, Zhang W, Zhang T, Niu Y. An associated classification of triple negative breast cancer: the risk of relapse and the response to chemotherapy. Int J Clin Exp Pathol. 2013;6:1380-91 pubmed
immunohistochemistry; human	Fawzy M, Aly N, Shalaby S, El Sawy W, Abdul Maksoud R. Cyclooxygenase-2 169C>G and 8473T>C gene polymorphisms and prostaglandin E2 level in breast cancer: a case-control study. Gene. 2013;527:601-5 pubmed publisher
immunohistochemistry; human; 1:250	Lai H, Tseng L, Chang T, Kuo Y, Hsieh C, Chen S, et al. The prognostic significance of metaplastic carcinoma of the breast (MCB)--a case controlled comparison study with infiltrating ductal carcinoma. Breast. 2013;22:968-73 pubmed publisher
chromatin immunoprecipitation; human; 3 ug immunocytochemistry; human; 1:400 western blot; human; 1:2000	Goddard L, Ton A, Org T, Mikkola H, Iruela Arispe M. Selective suppression of endothelial cytokine production by progesterone receptor. Vascul Pharmacol. 2013;59:36-43 pubmed publisher
immunohistochemistry; human	Hao J, Yang C, Liu F, Yang Y, Li S, Li W, et al. Accessory breast cancer occurring concurrently with bilateral primary invasive breast carcinomas: a report of two cases and literature review. Cancer Biol Med. 2012;9:197-201 pubmed publisher
immunohistochemistry; human; 1:1000	Gudlaugsson E, Klos J, Skaland I, Janssen E, Smaaland R, Feng W, et al. Prognostic comparison of the proliferation markers (mitotic activity index, phosphohistone H3, Ki67), steroid receptors, HER2, high molecular weight cytokeratins and classical prognostic factors in T???N?M? breast cancer. Pol J Pathol. 2013;64:1-8 pubmed
immunohistochemistry; human	Brouckaert O, Laenen A, Wildiers H, Floris G, Moerman P, Van Limbergen E, et al. The prognostic role of preoperative and (early) postoperatively change in CA15.3 serum levels in a single hospital cohort of primary operable breast cancers. Breast. 2013;22:254-62 pubmed publisher
immunohistochemistry - paraffin section; human; 1:100; tbl 2	Joensuu K, Leidenius M, Kero M, Andersson L, Horwitz K, Heikkila P. ER, PR, HER2, Ki-67 and CK5 in Early and Late Relapsing Breast Cancer-Reduced CK5 Expression in Metastases. Breast Cancer (Auckl). 2013;7:23-34 pubmed publisher
immunohistochemistry; human; 1:400	Makroo R, Chowdhry M, Kumar M, Srivastava P, Tyagi R, Bhadauria P, et al. Correlation between HER2 gene amplification and protein overexpression through fluorescence in situ hybridization and immunohistochemistry in breast carcinoma patients. Indian J Pathol Microbiol. 2012;55:481-4 pubmed publisher
immunohistochemistry; human	Hashad D, Sorour A, Ghazal A, Talaat I. Free circulating tumor DNA as a diagnostic marker for breast cancer. J Clin Lab Anal. 2012;26:467-72 pubmed publisher
immunohistochemistry; human; 1:500	Laliotis A, Vrekoussis T, Kafousi M, Sanidas E, Askoxilakis J, Melissas J, et al. Immunohistochemical study of pElk-1 expression in human breast cancer: association with breast cancer biologic profile and clinicopathologic features. Breast. 2013;22:89-95 pubmed publisher
immunohistochemistry; human; 1:100	Masago K, Hosada W, Sasaki E, Murakami Y, Sugano M, Nagasaka T, et al. Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature. Case Rep Oncol. 2012;5:471-8 pubmed publisher
immunohistochemistry; human; 1:500; tbl 1	Escobar J, Klimowicz A, Dean M, Chu P, Nation J, Nelson G, et al. Quantification of ER/PR expression in ovarian low-grade serous carcinoma. Gynecol Oncol. 2013;128:371-6 pubmed publisher
immunohistochemistry; human; 1:250	Yang L, Tseng H, Lin C, Chen L, Chen S, Kuo S, et al. Survival benefit of tamoxifen in estrogen receptor-negative and progesterone receptor-positive low grade breast cancer patients. J Breast Cancer. 2012;15:288-95 pubmed publisher
immunohistochemistry; human; 1:200	Marian C, Boilă A, Soanca D, Malau M, Podeanu D, Resetkova E, et al. Malignant transformation of adenomyoepithelioma of the breast by a monophasic population: a report of two cases and review of literature. APMIS. 2013;121:272-9 pubmed publisher
immunohistochemistry; human	Haltas H, Bayrak R, Yenidunya S, Kosehan D, Sen M, Akin K. Invasive lobular carcinoma with extracellular mucin as a distinct variant of lobular carcinoma: a case report. Diagn Pathol. 2012;7:91 pubmed publisher
immunohistochemistry; human	Grell P, Fabian P, Khoylou M, Radova L, Slaby O, Hrstka R, et al. Akt expression and compartmentalization in prediction of clinical outcome in HER2-positive metastatic breast cancer patients treated with trastuzumab. Int J Oncol. 2012;41:1204-12 pubmed publisher
immunohistochemistry; human; 1:50	Tergas A, Buell Gutbrod R, Gwin K, Kocherginsky M, Temkin S, Fefferman A, et al. Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure. Gynecol Oncol. 2012;127:316-20 pubmed publisher
immunohistochemistry; human; 1:50	Bonzanini M, Morelli L, Bonandini E, Leonardi E, Pertile R, Dalla Palma P. Cytologic features of triple-negative breast carcinoma. Cancer Cytopathol. 2012;120:401-9 pubmed publisher
immunohistochemistry; human; 1:1000	Jonsdottir K, Zhang H, Jhagroe D, Skaland I, Slewa A, Björkblom B, et al. The prognostic value of MARCKS-like 1 in lymph node-negative breast cancer. Breast Cancer Res Treat. 2012;135:381-90 pubmed publisher
immunohistochemistry; human; 1:200	Iqbal J, Thike A, Cheok P, Tse G, Tan P. Insulin growth factor receptor-1 expression and loss of PTEN protein predict early recurrence in triple-negative breast cancer. Histopathology. 2012;61:652-9 pubmed publisher
immunohistochemistry; human	Brouckaert O, Laenen A, Vanderhaegen J, Wildiers H, Leunen K, Amant F, et al. Applying the 2011 St Gallen panel of prognostic markers on a large single hospital cohort of consecutively treated primary operable breast cancers. Ann Oncol. 2012;23:2578-84 pubmed
immunohistochemistry; human	Svoboda M, Sana J, Redova M, Navratil J, Palacova M, Fabian P, et al. MiR-34b is associated with clinical outcome in triple-negative breast cancer patients. Diagn Pathol. 2012;7:31 pubmed publisher
immunohistochemistry; human	Zheng S, Bai J, Li J, Fan J, Pang Y, Song Q, et al. The pathologic characteristics of breast cancer in China and its shift during 1999-2008: a national-wide multicenter cross-sectional image over 10 years. Int J Cancer. 2012;131:2622-31 pubmed publisher
immunohistochemistry; human	Yigit S, Pehlivan F, Evcim G, Etit D. Clinicopathologic features of the mixed epithelial and mesenchymal type metaplastic breast carcinoma with myoepithelial differentiation in a subset of six cases. Pathol Res Pract. 2012;208:147-50 pubmed publisher
immunohistochemistry; human; 1:250	Lin C, Chen D, Chang K, Chang T, Wang H. A phase II study of neoadjuvant chemotherapy with docetaxel, cisplatin and trastuzumab for T2 breast cancers. Cancer Chemother Pharmacol. 2012;69:1363-8 pubmed publisher
immunohistochemistry; human; 1:100	Bozkurt K, Kapucuoglu N. Investigation of immunohistochemical ER?, ER? and ER?cx expressions in normal and neoplastic breast tissues. Pathol Res Pract. 2012;208:133-9 pubmed publisher
immunohistochemistry; human; 1:250	Lin C, Chien S, Kuo S, Chen L, Chen S, Lai H, et al. A 10-year follow-up of triple-negative breast cancer patients in Taiwan. Jpn J Clin Oncol. 2012;42:161-7 pubmed publisher
immunohistochemistry; human	Bolat F, Canpolat T, Tarim E. Pregnancy-related peritoneal ectopic decidua (deciduosis): morphological and clinical evaluation. Turk Patoloji Derg. 2012;28:56-60 pubmed publisher
immunohistochemistry; human; 1:250	Chen S, Lai H, Tseng H, Chen L, Kuo S, Chen D. Correlation of histologic grade with other clinicopathological parameters, intrinsic subtype, and patients' clinical outcome in Taiwanese women. Jpn J Clin Oncol. 2011;41:1327-35 pubmed publisher
immunohistochemistry; human; 1:200	El Gendi S, Mostafa M, El Gendi A. Stromal caveolin-1 expression in breast carcinoma. Correlation with early tumor recurrence and clinical outcome. Pathol Oncol Res. 2012;18:459-69 pubmed publisher
immunohistochemistry - paraffin section; dogs; 1:200	Chu P, Hsu N, Liao A, Shih N, Hou M, Liu C. Overexpression of ?-enolase correlates with poor survival in canine mammary carcinoma. BMC Vet Res. 2011;7:62 pubmed publisher
immunohistochemistry; human	Ramadan S, Yapicier O, Kıhtır S, Erdemir A, Doğan T, Uskent I, et al. Correlation of HER 2/neu gene amplification with immunohistochemistry and other prognostic factors in breast carcinoma. Turk Patoloji Derg. 2011;27:196-203 pubmed publisher
immunohistochemistry; human; 1:50	Ulasov I, Kaverina N, Pytel P, Thaci B, Liu F, Hurst D, et al. Clinical significance of KISS1 protein expression for brain invasion and metastasis. Cancer. 2012;118:2096-105 pubmed publisher
immunohistochemistry; human	Keskin S, Muslumanoglu M, Saip P, Karanlik H, Guveli M, Pehlivan E, et al. Clinical and pathological features of breast cancer associated with the pathological complete response to anthracycline-based neoadjuvant chemotherapy. Oncology. 2011;81:30-8 pubmed publisher
immunohistochemistry; human; 1:200	Singh A, Mishra A, Ylaya K, Hewitt S, Sharma K, Saxena S. Wilms tumor-1, claudin-1 and ezrin are useful immunohistochemical markers that help to distinguish schwannoma from fibroblastic meningioma. Pathol Oncol Res. 2012;18:383-9 pubmed publisher
immunohistochemistry; mouse; 1:200 western blot; mouse; 1:500	Heijmans J, Muncan V, Jacobs R, de Jonge Muller E, Graven L, Biemond I, et al. Intestinal tumorigenesis is not affected by progesterone signaling in rodent models. PLoS ONE. 2011;6:e22620 pubmed publisher
immunohistochemistry; human	Sun H, Zheng Y, Ou W, Fang Q, Li P, Ye X, et al. Association between hormone receptor expression and epidermal growth factor receptor mutation in patients operated on for non-small cell lung cancer. Ann Thorac Surg. 2011;91:1562-7 pubmed publisher
immunohistochemistry; mouse; 1:200; fig 1	Meyer D, Brinkhaus H, Müller U, Muller M, Cardiff R, Bentires Alj M. Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors. Cancer Res. 2011;71:4344-51 pubmed publisher
immunohistochemistry - paraffin section; human; 1:200	Teng Y, Tan W, Thike A, Cheok P, Tse G, Wong N, et al. Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy. Breast Cancer Res. 2011;13:R35 pubmed publisher
immunohistochemistry; human; 1:100	Guan B, Wang H, Cao S, Rao Q, Wang Y, Zhu Y, et al. Lipid-rich carcinoma of the breast clinicopathologic analysis of 17 cases. Ann Diagn Pathol. 2011;15:225-32 pubmed publisher
immunohistochemistry; dogs; 1:40	Bartel C, Berghold P, Walter I. Ectopic endometrial tissue in mesonephric duct remnants in bitches. Reprod Domest Anim. 2011;46:950-6 pubmed publisher
immunohistochemistry; human; 1:100	Chuah B, Putti T, Salto Tellez M, Charlton A, Iau P, Buhari S, et al. Serial changes in the expression of breast cancer-related proteins in response to neoadjuvant chemotherapy. Ann Oncol. 2011;22:1748-54 pubmed publisher
immunohistochemistry; human; 1:1000	Gudlaugsson E, Skaland I, Undersrud E, Janssen E, Søiland H, Baak J. D2-40/p63 defined lymph vessel invasion has additional prognostic value in highly proliferating operable node negative breast cancer patients. Mod Pathol. 2011;24:502-11 pubmed publisher
immunohistochemistry; human; 1:300	Ege C, Akbulut M, Zekioglu O, Ozdemir N. Investigation of galectin-3 and heparanase in endometrioid and serous carcinomas of the endometrium and correlation with known predictors of survival. Arch Gynecol Obstet. 2011;284:1231-9 pubmed publisher
immunohistochemistry; human; 1:250	Lai H, Kuo S, Chen L, Chi C, Chen S, Chang T, et al. Prognostic significance of triple negative breast cancer at tumor size 1 cm and smaller. Eur J Surg Oncol. 2011;37:18-24 pubmed publisher
immunohistochemistry; human	Kosemehmetoglu K, Guler G. Papillary apocrine metaplasia and columnar cell lesion with atypia: is there a shared common pathway?. Ann Diagn Pathol. 2010;14:425-31 pubmed publisher
immunohistochemistry; human; 1:1	Abdelzaher E, El Gendi S, Yehya A, Gowil A. Recurrence of benign meningiomas: predictive value of proliferative index, BCL2, p53, hormonal receptors and HER2 expression. Br J Neurosurg. 2011;25:707-13 pubmed publisher
immunohistochemistry; human	Rhodes A, Sarson J, Assam E, Dean S, Cribb E, Parker A. The reliability of rabbit monoclonal antibodies in the immunohistochemical assessment of estrogen receptors, progesterone receptors, and HER2 in human breast carcinomas. Am J Clin Pathol. 2010;134:621-32 pubmed publisher
immunohistochemistry; human; 1:200	Lwin Z, Guo C, Salim A, Yip G, Chew F, Nan J, et al. Clinicopathological significance of calreticulin in breast invasive ductal carcinoma. Mod Pathol. 2010;23:1559-66 pubmed publisher
western blot; human; 1:1000	Janssen E, Slewa A, Gudlaugsson E, Jonsdottir K, Skaland I, Søiland H, et al. Biologic profiling of lymph node negative breast cancers by means of microRNA expression. Mod Pathol. 2010;23:1567-76 pubmed publisher
immunohistochemistry; human; 1:200	Giordano G, Lombardi M, Brigati F, Mancini C, Silini E. Clinicopathologic features of 2 new cases of uterine tumors resembling ovarian sex cord tumors. Int J Gynecol Pathol. 2010;29:459-67 pubmed publisher
immunohistochemistry; human; 1:200	Chen C, Xia H, Gong Y, Peng J, Peng C, Hu M, et al. The quantitative detection of total HER2 load by quantum dots and the identification of a new subtype of breast cancer with different 5-year prognosis. Biomaterials. 2010;31:8818-25 pubmed publisher
immunohistochemistry - paraffin section; human; 1:250; fig 2, 3, 4 immunohistochemistry; human; 1:250	Baydar D, Kulac I, Gurel B, De Marzo A. A case of prostatic adenocarcinoma with aberrant p63 expression: presentation with detailed immunohistochemical study and FISH analysis. Int J Surg Pathol. 2011;19:131-6 pubmed publisher
immunocytochemistry; human; 1:150 immunohistochemistry; human; 1:150	Bohn O, Fuertes Camilo M, Navarro L, Saldivar J, Sanchez Sosa S. p16INK4a expression in basal-like breast carcinoma. Int J Clin Exp Pathol. 2010;3:600-7 pubmed
immunohistochemistry; human; 1:400	Alkushi A, Köbel M, Kalloger S, Gilks C. High-grade endometrial carcinoma: serous and grade 3 endometrioid carcinomas have different immunophenotypes and outcomes. Int J Gynecol Pathol. 2010;29:343-50 pubmed publisher
immunohistochemistry; human; 1:25	de Neergaard M, Kim J, Villadsen R, Fridriksdottir A, Rank F, Timmermans Wielenga V, et al. Epithelial-stromal interaction 1 (EPSTI1) substitutes for peritumoral fibroblasts in the tumor microenvironment. Am J Pathol. 2010;176:1229-40 pubmed publisher
immunohistochemistry; human; 1:100	Wang H, Guan B, Shi Q, Ma H, Zhou H, Wang X, et al. May metaplastic breast carcinomas be actually basal-like carcinoma? Further evidence study with its ultrastructure and survival analysis. Med Oncol. 2011;28:42-50 pubmed publisher
immunohistochemistry; dogs; 1:40	Bartel C, Schönkypl S, Walter I. Pseudo-placentational endometrial cysts in a bitch. Anat Histol Embryol. 2010;39:74-80 pubmed publisher
immunohistochemistry; human; 1:200	Thike A, Cheok P, Jara Lazaro A, Tan B, Tan P, Tan P. Triple-negative breast cancer: clinicopathological characteristics and relationship with basal-like breast cancer. Mod Pathol. 2010;23:123-33 pubmed publisher
immunohistochemistry; human	Chen H, Huang H, Li C, Ko S, Changchien C, Chen W, et al. Synchronous presentation of uterine leiomyosarcoma and retroperitoneal liposarcoma: analysis by comparative genomic hybridization and review of the literature. Int J Gynecol Pathol. 2009;28:535-40 pubmed publisher
immunohistochemistry; human; 1:500	Celestino R, Magalhães J, Castro P, Triller M, Vinagre J, Soares P, et al. A follicular variant of papillary thyroid carcinoma in struma ovarii. Case report with unique molecular alterations. Histopathology. 2009;55:482-7 pubmed publisher
immunohistochemistry; human; 1:75	Raso M, Behrens C, Herynk M, Liu S, Prudkin L, Ozburn N, et al. Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation. Clin Cancer Res. 2009;15:5359-68 pubmed publisher
western blot; human	Rao A, Ziegler Y, McLeod I, Yates J, Nardulli A. Thioredoxin and thioredoxin reductase influence estrogen receptor alpha-mediated gene expression in human breast cancer cells. J Mol Endocrinol. 2009;43:251-61 pubmed publisher
immunohistochemistry; human	Wang L, Jiang Z, Sui M, Shen J, Xu C, Fan W. The potential biomarkers in predicting pathologic response of breast cancer to three different chemotherapy regimens: a case control study. BMC Cancer. 2009;9:226 pubmed publisher
immunohistochemistry; human; 1:200	Locati L, Perrone F, Losa M, Mela M, Casieri P, Orsenigo M, et al. Treatment relevant target immunophenotyping of 139 salivary gland carcinomas (SGCs). Oral Oncol. 2009;45:986-90 pubmed publisher
western blot; human; 1:250	Lin C, Chien S, Chen L, Kuo S, Chang T, Chen D. Triple negative breast carcinoma is a prognostic factor in Taiwanese women. BMC Cancer. 2009;9:192 pubmed publisher
immunohistochemistry; human; 1:300	Rocha R, Nunes C, Sanches F, Rocha G, Oliveira F, Reis Filho J, et al. Rabbit antibodies for hormone receptors and HER2 evaluation in breast cancer. Rev Assoc Med Bras (1992). 2009;55:163-8 pubmed
immunohistochemistry; human; 1:200	Snyder E, Bailey D, Shipitsin M, Polyak K, Loda M. Identification of CD44v6(+)/CD24- breast carcinoma cells in primary human tumors by quantum dot-conjugated antibodies. Lab Invest. 2009;89:857-66 pubmed publisher
western blot; human	Curtis C, Thorngren D, Ziegler Y, Sarkeshik A, Yates J, Nardulli A. Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression. Mol Endocrinol. 2009;23:1346-59 pubmed publisher
immunohistochemistry; human; 1:50	Blance R, Sims A, Anderson E, Howell A, Clarke R. Normal breast tissue implanted into athymic nude mice identifies biomarkers of the effects of human pregnancy levels of estrogen. Cancer Prev Res (Phila). 2009;2:257-64 pubmed publisher
immunohistochemistry; human; 1:200	Tezel G, Uner A, Yildiz I, Guler G, Takahashi M. RET finger protein expression in invasive breast carcinoma: relationship between RFP and ErbB2 expression. Pathol Res Pract. 2009;205:403-8 pubmed publisher
immunohistochemistry; human; 1:400	Hanley K, Siddiqui M, Lawson D, Cohen C, Nassar A. Evaluation of new monoclonal antibodies in detection of estrogen receptor, progesterone receptor, and Her2 protein expression in breast carcinoma cell block sections using conventional microscopy and quantitative image analysis. Diagn Cytopathol. 2009;37:251-7 pubmed publisher
immunohistochemistry; human; 1:400	Søiland H, Skaland I, Varhaug J, Kørner H, Janssen E, Gudlaugsson E, et al. Co-expression of estrogen receptor alpha and Apolipoprotein D in node positive operable breast cancer--possible relevance for survival and effects of adjuvant tamoxifen in postmenopausal patients. Acta Oncol. 2009;48:514-21 pubmed publisher
immunohistochemistry; dogs; 1:100	Stadler K, Handler J, Schoenkypl S, Walter I. A three-dimensional culture model of canine uterine glands. In Vitro Cell Dev Biol Anim. 2009;45:35-43 pubmed publisher
immunohistochemistry; human; 1:400	Søiland H, Kørner H, Skaland I, Janssen E, Gudlaugsson E, Varhaug J, et al. Prognostic relevance of androgen receptor detection in operable breast cancer. J Surg Oncol. 2008;98:551-8 pubmed publisher
immunohistochemistry; human; 1:300	Rocha R, Nunes C, Rocha G, Oliveira F, Sanches F, Gobbi H. Rabbit monoclonal antibodies show higher sensitivity than mouse monoclonals for estrogen and progesterone receptor evaluation in breast cancer by immunohistochemistry. Pathol Res Pract. 2008;204:655-62 pubmed publisher
immunohistochemistry; human	Horwitz K, Dye W, Harrell J, Kabos P, Sartorius C. Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts. Proc Natl Acad Sci U S A. 2008;105:5774-9 pubmed publisher
immunohistochemistry; human	Kaya H, Bozkurt S, Erbarut I, Djamgoz M. Apocrine carcinomas of the breast in Turkish women: hormone receptors, c-erbB-2 and p53 immunoexpression. Pathol Res Pract. 2008;204:367-71 pubmed publisher
immunohistochemistry; human	Van Calster B, Vanden Bempt I, Drijkoningen M, Pochet N, Cheng J, Van Huffel S, et al. Axillary lymph node status of operable breast cancers by combined steroid receptor and HER-2 status: triple positive tumours are more likely lymph node positive. Breast Cancer Res Treat. 2009;113:181-7 pubmed publisher
immunohistochemistry; human; 1:500	De Maeyer L, Van Limbergen E, De Nys K, Moerman P, Pochet N, Hendrickx W, et al. Does estrogen receptor negative/progesterone receptor positive breast carcinoma exist?. J Clin Oncol. 2008;26:335-6; author reply 336-8 pubmed publisher
immunohistochemistry; human	Eroglu A, Sari A. Expression of c-kit proto-oncogene product in breast cancer tissues. Med Oncol. 2007;24:169-74 pubmed
immunohistochemistry; mouse; 1:100	Girling J, Lederman F, Walter L, Rogers P. Progesterone, but not estrogen, stimulates vessel maturation in the mouse endometrium. Endocrinology. 2007;148:5433-41 pubmed
immunohistochemistry; human	Neven P, Van Calster B, Van den Bempt I, Van Huffel S, Van Belle V, Hendrickx W, et al. Age interacts with the expression of steroid and HER-2 receptors in operable invasive breast cancer. Breast Cancer Res Treat. 2008;110:153-9 pubmed
immunohistochemistry; human; 1:500	Verlinden L, Vanden Bempt I, Eelen G, Drijkoningen M, Verlinden I, Marchal K, et al. The E2F-regulated gene Chk1 is highly expressed in triple-negative estrogen receptor /progesterone receptor /HER-2 breast carcinomas. Cancer Res. 2007;67:6574-81 pubmed
immunohistochemistry; human; 1:70	Wong S, Chan J, Lo E, Chan A, Wong M, Chan C, et al. The contribution of bifunctional SkipDewax pretreatment solution, rabbit monoclonal antibodies, and polymer detection systems in immunohistochemistry. Arch Pathol Lab Med. 2007;131:1047-55 pubmed
immunohistochemistry; human; 1:200	Giordano G, D Adda T, Gnetti L, Merisio C, Raboni S. Transitional cell carcinoma of the endometrium associated with benign ovarian brenner tumor: a case report with immunohistochemistry molecular analysis and a review of the literature. Int J Gynecol Pathol. 2007;26:298-304 pubmed
immunohistochemistry; human; 1:600	Decock J, Hendrickx W, Drijkoningen M, Wildiers H, Neven P, Smeets A, et al. Matrix metalloproteinase expression patterns in luminal A type breast carcinomas. Dis Markers. 2007;23:189-96 pubmed
immunohistochemistry; human; 1:200	Giordano G, D Adda T, Gnetti L, Merisio C, Gabrielli M, Melpignano M. Villoglandular adenocarcinoma of the cervix: two new cases with morphological and molecular study. Int J Gynecol Pathol. 2007;26:199-204 pubmed
immunohistochemistry; human	Nadasi E, Anga B, Sandor J, Megyesi J, Kelemen D, Mottolese M, et al. Prognostic factors in Hungarian breast cancer patients. Anticancer Res. 2007;27:279-82 pubmed
immunohistochemistry; human; 1:100	Kapucuoglu N, Aktepe F, Kaya H, Bircan S, Karahan N, Ciris M. Immunohistochemical expression of PTEN in normal, hyperplastic and malignant endometrium and its correlation with hormone receptors, bcl-2, bax, and apoptotic index. Pathol Res Pract. 2007;203:153-62 pubmed
western blot; human	Rasmussen L, Zaveri N, Stenvang J, Peters R, Lykkesfeldt A. A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer. Breast Cancer Res Treat. 2007;106:191-203 pubmed
immunohistochemistry; human; 1:300 western blot; human; 1:300 immunohistochemistry; mouse; 1:300 western blot; mouse; 1:300	Teilmann S, Clement C, Thorup J, Byskov A, Christensen S. Expression and localization of the progesterone receptor in mouse and human reproductive organs. J Endocrinol. 2006;191:525-35 pubmed
immunohistochemistry; human; 1:400	Wiseman S, Masoudi H, Niblock P, Turbin D, Rajput A, Hay J, et al. Anaplastic thyroid carcinoma: expression profile of targets for therapy offers new insights for disease treatment. Ann Surg Oncol. 2007;14:719-29 pubmed
immunohistochemistry; human; 1:200	Sabah M, Mohan P, Kay E. Para-testicular cellular angiofibroma: a rare tumour in a male renal transplant patient. Virchows Arch. 2006;449:489-92 pubmed
immunohistochemistry; human	Goh B, Tan Y, Kumarasinghe M, Ooi L. Mucinous cystic tumor of the pancreas with ovarian-like mesenchymal stroma in a male patient. Dig Dis Sci. 2005;50:2170-7 pubmed
immunohistochemistry; human	Hascalik S, Celik O, Erdem G, Usta U, Alkan A, Karakas H, et al. Synchronous endometrial and cervical tumors in a 26-year-old nullipara: diagnostic modalities updated. Gynecol Obstet Invest. 2005;60:171-6 pubmed
western blot; human; 1:2000	Sonne Hansen K, Lykkesfeldt A. Endogenous aromatization of testosterone results in growth stimulation of the human MCF-7 breast cancer cell line. J Steroid Biochem Mol Biol. 2005;93:25-34 pubmed
immunohistochemistry; human; 1:200	Giordano G, D Adda T, Merisio C, Gnetti L. Primary squamous cell carcinoma of the endometrium: a case report with immunohistochemical and molecular study. Gynecol Oncol. 2005;96:876-9 pubmed
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product information

Product Type :

Antibody

Product Name :

Progesterone Receptor Monoclonal Antibody (SP2)

Catalog # :

MA5-14505

Quantity :

500 uL

Price :

US 920.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:400, Western Blot: 1:1,000-1:2,000

Species :

Human

Clone :

SP2

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles, store in dark

Description :

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.

Immunogen :

Recombinant protein encoding human progesterone receptor 412-526 aa

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:100, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:400, Western Blot: 1:1,000-1:2,000

Aliases :

9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product

more info or order :

Invitrogen product webpage