beta Catenin Monoclonal Antibody (E247) | Invitrogen MA5-14461 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

beta Catenin Monoclonal Antibody (E247)

catalog :

MA5-14461

quantity :

1 mL

price :

US 830.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

E247

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:400; tbl 4	Lu B, Chen Q, Zhang X, Cheng L. Serous carcinoma arising from uterine adenomyosis/adenomyotic cyst of the cervical stump: a report of 3 cases. Diagn Pathol. 2016;11:46 pubmed publisher
immunohistochemistry - paraffin section; human; 1:50	Malchenko S, Sredni S, Hashimoto H, Kasai A, Nagayasu K, Xie J, et al. A mouse model of human primitive neuroectodermal tumors resulting from microenvironmentally-driven malignant transformation of orthotopically transplanted radial glial cells. PLoS ONE. 2015;10:e0121707 pubmed publisher
immunohistochemistry - paraffin section; human; 1:1; loading ...; tbl 3	Sasaki M, Yoneda N, Kitamura S, Sato Y, Nakanuma Y. Characterization of hepatocellular adenoma based on the phenotypic classification: The Kanazawa experience. Hepatol Res. 2011;41:982-8 pubmed publisher
	Indra I, Troyanovsky R, Green K, Troyanovsky S. Plakophilin 3 and Par3 Facilitate Desmosomes' association with the Apical Junctional Complex. Mol Biol Cell. 2021;:mbcE21010001 pubmed publisher
	Youssef N, Osman W. Relationship between osteopontin and Î²-catenin immunohistochemical expression and prognostic parameters of colorectal carcinoma. Int J Clin Exp Pathol. 2015;8:1503-14 pubmed

product information

Product Type :

Antibody

Product Name :

beta Catenin Monoclonal Antibody (E247)

Catalog # :

MA5-14461

Quantity :

1 mL

Price :

US 830.00

Clonality :

Monoclonal

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): 1:125, Western Blot: 1:500

Species :

Human, Mouse

Clone :

E247

Isotype :

IgG

Storage :

4° C

Description :

Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation. The influence on cell proliferation is the molecular basis for the role of beta-catenin in tumorgenesis, specifically, solid tumors of the breast, colon, liver, lung, gastric, prostate, and skin.

Immunogen :

A synthetic peptide derived from near the N-terminus of human beta-catenin

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): 1:125, Western Blot: 1:500

Aliases :

armadillo; armadillo homolog; Bcatenin; b-catenin; beta 1 88kDa; beta catenin; Betacatenin; beta-catenin; beta-catenin 1; Bfc; C20orf33; Cadherin associated protein; catenin; catenin (cadherin associated protein), beta 1; catenin (cadherin associated protein), beta 1, 88kDa; catenin (cadherin-associated protein) beta 1; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; Catenin b 1; Catenin b1; catenin beta; catenin beta 1; catenin beta 1 L homeolog; Catenin beta1; Catenin beta-1; Catenin ß 1; Catenin ß1; Catnb; CHBCAT; CTNB1; CTNNB; ctnnb1; ctnnb1.L; ctnnb1-a; ctnnb1-b; dJ633O20.1; DKFZp686D02253; FLJ25606; FLJ37923; id:ibd2058; Mesc; MRD19; NAP; NYD-SP19; OK/SW-cl.35; OTTHUMP00000209289; P14L; PP8304; PRO2286; RP5-1118M15.1; wu:fb73e10; wu:fi81c06; wu:fk25h01; XELAEV_18031149mg; ß catenin; ßcatenin