E-cadherin Monoclonal Antibody (EP700Y) | Invitrogen MA5-14458 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

E-cadherin Monoclonal Antibody (EP700Y)

catalog :

MA5-14458

quantity :

1 mL

price :

US 650.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

EP700Y

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:200; fig 1	Song D, Ko G, Lee J, Lee J, Lee G, Kim H, et al. Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression. Oncol Lett. 2016;11:998-1006 pubmed
immunocytochemistry; human	Lupu Meiri M, Geras Raaka E, Lupu R, Shapira H, Sandbank J, Segal L, et al. Knock-down of plasminogen-activator inhibitor-1 enhances expression of E-cadherin and promotes epithelial differentiation of human pancreatic adenocarcinoma cells. J Cell Physiol. 2012;227:3621-8 pubmed publisher
	Dardare J, Witz A, Betz M, Francois A, Meras M, Lamy L, et al. DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy. Front Oncol. 2022;12:1052163 pubmed publisher
	Wahlsten A, R xfc tsche D, Nanni M, Giampietro C, Biedermann T, Reichmann E, et al. Mechanical stimulation induces rapid fibroblast proliferation and accelerates the early maturation of human skin substitutes. Biomaterials. 2021;273:120779 pubmed publisher
	Ilina O, Campanello L, Gritsenko P, Vullings M, Wang C, Bult P, et al. Intravital microscopy of collective invasion plasticity in breast cancer. Dis Model Mech. 2018;11: pubmed publisher
	Khalil A, Ilina O, Gritsenko P, Bult P, Span P, Friedl P. Collective invasion in ductal and lobular breast cancer associates with distant metastasis. Clin Exp Metastasis. 2017;34:421-429 pubmed publisher

product information

Product Type :

Antibody

Product Name :

E-cadherin Monoclonal Antibody (EP700Y)

Catalog # :

MA5-14458

Quantity :

1 mL

Price :

US 650.00

Clonality :

Monoclonal

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:50

Species :

Human

Clone :

EP700Y

Isotype :

IgG

Storage :

4° C

Description :

E-Cadherin (epithelial cadherin) is a classical cadherin from the cadherin (alcium dependent adhesion protein) superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. E-cadherin plays a central role in the growth and development of cells by controlling tissue architecture, and maintenance of tissue integrity. In humans, E-cadherin is encoded by the CDH1 gene present on chromosome 16. Studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

Immunogen :

A synthetic peptide derived from the fifth cadherin domain of human cadherin

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:50

Aliases :

AA960649; ARC-1; cadherin 1; cadherin 1, E-cadherin (epithelial); cadherin 1, epithelial; cadherin 1, type 1; cadherin 1, type 1, E-cadherin (epithelial); cadherin e; cadherin-1; cadherin-E; calcium-dependent adhesion protein, epithelial; CAM 120/80; CD324; CDH1; CDHE; cell adhesion molecule; cell-CAM 120/80; ECAD; E-cad; E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3; Ecadherin; E-cadherin; E-cadherin 1; E-cadherin precursor; Epithelial cadherin; hab; half baked; LCAM; L-CAM; Um; UVO; Uvomorulin