c-Abl Monoclonal Antibody (8E9), Biotin | Invitrogen MA5-14395 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

c-Abl Monoclonal Antibody (8E9), Biotin

catalog :

MA5-14395

quantity :

500µL

price :

US 399.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

8E9

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human	Noguera I, Sun C, Broaddus R, Branham D, Levenback C, Ramirez P, et al. Phase II trial of imatinib mesylate in patients with recurrent platinum- and taxane-resistant low-grade serous carcinoma of the ovary, peritoneum, or fallopian tube. Gynecol Oncol. 2012;125:640-5 pubmed publisher
immunoprecipitation; mouse immunocytochemistry; mouse western blot; mouse	Baker M, Hetherington L, Curry B, Aitken R. Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa; its implications during capacitation. Dev Biol. 2009;333:57-66 pubmed publisher
immunohistochemistry; human	Coleman R, Broaddus R, Bodurka D, Wolf J, Burke T, Kavanagh J, et al. Phase II trial of imatinib mesylate in patients with recurrent platinum- and taxane-resistant epithelial ovarian and primary peritoneal cancers. Gynecol Oncol. 2006;101:126-31 pubmed
	Slomovitz B, Broaddus R, Schmandt R, Wu W, Oh J, Ramondetta L, et al. Expression of imatinib mesylate-targeted kinases in endometrial carcinoma. Gynecol Oncol. 2004;95:32-6 pubmed
	Schmandt R, Broaddus R, Lu K, Shvartsman H, Thornton A, Malpica A, et al. Expression of c-ABL, c-KIT, and platelet-derived growth factor receptor-beta in ovarian serous carcinoma and normal ovarian surface epithelium. Cancer. 2003;98:758-64 pubmed

product information

Product Type :

Antibody

Product Name :

c-Abl Monoclonal Antibody (8E9), Biotin

Catalog # :

MA5-14395

Quantity :

500µL

Price :

US 399.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:10-1:100, Immunofluorescence: 1:10-1:100, Immunohistochemistry (Paraffin): 12-24 µg/ml, Immunoprecipitation: 2 µg/mg lysate, Western Blot: 1 µg/mL

Species :

Human, Mouse

Clone :

8E9

Isotype :

IgG1

Storage :

4° C

Description :

The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.

Immunogen :

Recombinant Abl protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:10-1:100, Immunofluorescence: 1:10-1:100, Immunohistochemistry (Paraffin): 12-24 µg/ml, Immunoprecipitation: 2 µg/mg lysate, Western Blot: 1 µg/mL

Aliases :

bcr/c-abl oncogene protein, proto-oncogene c-Abl, proto-oncogene tyrosine-protein kinase ABL1, tyrosine-protein kinase ABL1, v-abl Abelson murine leukemia viral oncogene homolog 1