This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
E2F1 Monoclonal Antibody (KH95)
catalog :
MA5-14344
quantity :
500 uL
price :
US 474.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
KH95

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 11
Reference
Elias A, Gritsenko N, Gorovits R, Spector I, Prag G, Yagil E, et al. Anti-cancer binary system activated by bacteriophage HK022 integrase. Oncotarget. 2018;9:27487-27501 pubmed publisher
Silva A, Santos A, Farfel J, Grinberg L, Ferretti R, Campos A, et al. Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease. PLoS ONE. 2014;9:e99897 pubmed publisher
McClendon A, Dean J, Rivadeneira D, Yu J, Reed C, Gao E, et al. CDK4/6 inhibition antagonizes the cytotoxic response to anthracycline therapy. Cell Cycle. 2012;11:2747-55 pubmed publisher
Xanthoulis A, Kotsinas A, Tiniakos D, Fiska A, Tentes A, Kyroudi A, et al. The relationship between E2F family members and tumor growth in colorectal adenocarcinomas: A comparative immunohistochemical study of 100 cases. Appl Immunohistochem Mol Morphol. 2014;22:471-7 pubmed publisher
Jung Y, Joo K, Seong D, Choi Y, Kong D, Kim Y, et al. Identification of prognostic biomarkers for glioblastomas using protein expression profiling. Int J Oncol. 2012;40:1122-32 pubmed publisher
Vékony H, Roser K, Löning T, Raaphorst F, Leemans C, Van der Waal I, et al. Deregulated expression of p16INK4a and p53 pathway members in benign and malignant myoepithelial tumours of the salivary glands. Histopathology. 2008;53:658-66 pubmed publisher
Lee J, Park C, Park J, Lim T, Park Y, Lim H, et al. Impact of E2F-1 expression on clinical outcome of gastric adenocarcinoma patients with adjuvant chemoradiation therapy. Clin Cancer Res. 2008;14:82-8 pubmed publisher
Kawagoe H, Kandilci A, Kranenburg T, Grosveld G. Overexpression of N-Myc rapidly causes acute myeloid leukemia in mice. Cancer Res. 2007;67:10677-85 pubmed
Bromberg Z, Raj N, Goloubinoff P, Deutschman C, Weiss Y. Enhanced expression of 70-kilodalton heat shock protein limits cell division in a sepsis-induced model of acute respiratory distress syndrome. Crit Care Med. 2008;36:246-55 pubmed
Au N, Cheang M, Huntsman D, Yorida E, Coldman A, Elliott W, et al. Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers. J Pathol. 2004;204:101-9 pubmed
Hsueh C, Wu Y, Schwartz G. UCN-01 suppresses E2F-1 mediated by ubiquitin-proteasome-dependent degradation. Clin Cancer Res. 2001;7:669-74 pubmed
product information
Product Type :
Antibody
Product Name :
E2F1 Monoclonal Antibody (KH95)
Catalog # :
MA5-14344
Quantity :
500 uL
Price :
US 474.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Gel Shift: 1mg/mL, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 ug/mg protein lysate, Western Blot: 1-2 ug/mL
Species :
Human, Mouse
Clone :
KH95
Isotype :
IgG2a, kappa
Storage :
4 C
Description :
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Immunogen :
Recombinant human E2F-1 protein
Format :
Liquid
Applications w/Dilutions :
Gel Shift: 1mg/mL, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 ug/mg protein lysate, Western Blot: 1-2 ug/mL
Aliases :
E2F transcription factor 1; E2F1; E2F-1; mKIAA4009; PBR3; PRB-binding protein E2F-1; RBAP1; RBAP-1; RBBP3; RBBP-3; RBP3; Retinoblastoma-associated protein 1; retinoblastoma-binding protein 3; Transcription factor E2F1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA