Cdc6 Monoclonal Antibody (DCS-180) | Invitrogen MA5-14314 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cdc6 Monoclonal Antibody (DCS-180)

catalog :

MA5-14314

quantity :

500 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DCS-180

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 1	Tichy E, Pillai R, Deng L, Tischfield J, Hexley P, Babcock G, et al. The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels. Stem Cell Res. 2012;9:124-34 pubmed publisher
western blot; rat	Uranbileg B, Yamamoto H, Park J, Mohanty A, Arakawa Takeuchi S, Jinno S, et al. Cdc6 protein activates p27KIP1-bound Cdk2 protein only after the bound p27 protein undergoes C-terminal phosphorylation. J Biol Chem. 2012;287:6275-83 pubmed publisher
western blot; human	Tran K, Kamil J, Coen D, Spector D. Inactivation and disassembly of the anaphase-promoting complex during human cytomegalovirus infection is associated with degradation of the APC5 and APC4 subunits and does not require UL97-mediated phosphorylation of Cdh1. J Virol. 2010;84:10832-43 pubmed publisher
western blot; human	Menichincheri M, Bargiotti A, Berthelsen J, Bertrand J, Bossi R, Ciavolella A, et al. First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. J Med Chem. 2009;52:293-307 pubmed publisher
western blot; human	Norseen J, Thomae A, Sridharan V, Aiyar A, Schepers A, Lieberman P. RNA-dependent recruitment of the origin recognition complex. EMBO J. 2008;27:3024-35 pubmed publisher
	Christensen K, Brennan J, Aldridge C, Ford H. Cell cycle regulation of the human Six1 homeoprotein is mediated by APC(Cdh1). Oncogene. 2007;26:3406-14 pubmed

product information

Product Type :

Antibody

Product Name :

Cdc6 Monoclonal Antibody (DCS-180)

Catalog # :

MA5-14314

Quantity :

500 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Immunoprecipitation: 2 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human

Clone :

DCS-180

Isotype :

IgG1

Storage :

4 C

Description :

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.

Immunogen :

Recombinant human CDC6 protein

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: 2 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

CDC18(S.pombe); CDC18L; cdc18-related protein; CDC6; CDC6 cell division cycle 6 homolog; CDC6-related protein; Cell division control protein 6 homolog; cell division cycle 6; cell division cycle 6 homolog; HsCDC18; HsCDC6; p62(cdc6)

more info or order :

Invitrogen product webpage