MCM7 Monoclonal Antibody (47DC141 (DCS-141)) | Invitrogen MA5-14291 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MCM7 Monoclonal Antibody (47DC141 (DCS-141))

catalog :

MA5-14291

quantity :

500 µL

price :

US 496.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

47DC141 (DCS-141)

reactivity :

human, mouse, rat, dogs, Xenopus laevis

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 13

Reference
Romero Masters J, Grace M, Lee D, Lei J, DePamphilis M, Buehler D, et al. MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease. PLoS Pathog. 2023;19:e1011215 pubmed publisher
Blaine Sauer S, Shin M, Matkowskyj K, Ward Shaw E, Lambert P. A Novel Model for Papillomavirus-Mediated Anal Disease and Cancer Using the Mouse Papillomavirus. MBio. 2021;12:e0161121 pubmed publisher
Beziat V, Rapaport F, Hu J, Titeux M, Bonnet des Claustres M, Bourgey M, et al. Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Cell. 2021;184:3812-3828.e30 pubmed publisher
Cladel N, Budgeon L, Hu J, Balogh K, Christensen N. Synonymous codon changes in the oncogenes of the cottontail rabbit papillomavirus lead to increased oncogenicity and immunogenicity of the virus. Virology. 2013;438:70-83 pubmed publisher
Leite E, Souza C, Carvalho Júnior A, Coelho L, Lana A, Cassali G, et al. Encapsulation of cisplatin in long-circulating and pH-sensitive liposomes improves its antitumor effect and reduces acute toxicity. Int J Nanomedicine. 2012;7:5259-69 pubmed publisher
Kliszczak A, Rainey M, Harhen B, Boisvert F, Santocanale C. DNA mediated chromatin pull-down for the study of chromatin replication. Sci Rep. 2011;1:95 pubmed publisher
Berlato D, Stewart J, Newton R, Maglennon G, Monti P, Flindall A, et al. Evaluation of minichromosome maintenance protein 7 as a prognostic marker in canine cutaneous mast cell tumours. Vet Comp Oncol. 2012;10:135-42 pubmed publisher
Jabbar S, Abrams L, Glick A, Lambert P. Persistence of high-grade cervical dysplasia and cervical cancer requires the continuous expression of the human papillomavirus type 16 E7 oncogene. Cancer Res. 2009;69:4407-14 pubmed publisher
Peev N, Tonchev A, Penkowa M, Kalevski S, Haritonov D, Chaldakov G. Cell proliferation index predicts relapse of brain metastases in non-irradiated patients. Acta Neurochir (Wien). 2008;150:1043-8; discussion 1048 pubmed publisher
Balsitis S, Dick F, Dyson N, Lambert P. Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis. Cancer Res. 2006;66:9393-400 pubmed
Shen H, Sikorska M, Leblanc J, Walker P, Liu Q. Oxidative stress regulated expression of ubiquitin Carboxyl-terminal Hydrolase-L1: role in cell survival. Apoptosis. 2006;11:1049-59 pubmed
Kingsbury S, Loddo M, Fanshawe T, Obermann E, Prevost A, Stoeber K, et al. Repression of DNA replication licensing in quiescence is independent of geminin and may define the cell cycle state of progenitor cells. Exp Cell Res. 2005;309:56-67 pubmed
Wiebusch L, Uecker R, Hagemeier C. Human cytomegalovirus prevents replication licensing by inhibiting MCM loading onto chromatin. EMBO Rep. 2003;4:42-6 pubmed

product information

Product Type :

Antibody

Product Name :

MCM7 Monoclonal Antibody (47DC141 (DCS-141))

Catalog # :

MA5-14291

Quantity :

500 µL

Price :

US 496.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Canine, Human, Mouse, Rat, Xenopus laevis

Applications :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 0.5-1.0 µg/mL, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1-2 µg/mL

Species :

Canine, Human, Mouse, Rat, Xenopus laevis

Clone :

47DC141 (DCS-141)

Isotype :

IgG1

Storage :

4° C

Description :

MCM7 encodes a protein that is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Immunogen :

Recombinant hCDC47 protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 0.5-1.0 µg/mL, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1-2 µg/mL

Aliases :

AI747533; CDC47; CDC47 homolog; CDC47 homolog A; CDC47p; DNA replication licensing factor MCM7; DNA replication licensing factor mcm7-A; DNA replication licensing factor MCM7-like protein; homolog of S. cerevisiae Cdc47; mCDC47; MCM2; MCM7; MCM7 minichromosome maintenance deficient 7; mcm7.S; mcm7-a; mcm7-b; Mcmd7; mini chromosome maintenance deficient 7; minichromosome maintenance complex component 7; minichromosome maintenance complex component 7 S homeolog; minichromosome maintenance deficient 7; minichromosome maintenance deficient 7 (S. cerevisiae); minichromosome maintenance protein 7; minichromosome maintenance protein 7-A; P1 P85MCM; P1.1-MCM3; P1CDC47; P85MCM; p90; PNAS146; PPP1R104; protein phosphatase 1, regulatory subunit 104; Unknown (protein for MGC:128845); XELAEV_18000877mg; XMCM7; xMCM7-A