This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MCM7 Monoclonal Antibody (47DC141 or DCS-141), Biotin
catalog :
MA5-14288
quantity :
500µL
price :
US 399.00
clonality :
monoclonal
host :
mouse
conjugate :
biotin
clone name :
47DC141 or DCS-141
reactivity :
human, mouse, rat, dog, common platanna, rabbit
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 20
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse
de Fátima Pereira A, Mara da Costa V, Cristina Magalhães Santos M, Maciel de A Ribeiro R, Gabriela Silva A, Carmo Horta Pinto F, et al. Evaluation of the effects of methotrexate released from polymeric implants in solid Ehrlich tumor. Biomed Pharmacother. 2014;68:365-8 pubmed publisher
  • immunohistochemistry; mouse; 1:300
de Souza C, Araújo E Silva A, de Jesus Ferraciolli C, Moreira G, Campos L, Dos Reis D, et al. Combination therapy with carboplatin and thalidomide suppresses tumor growth and metastasis in 4T1 murine breast cancer model. Biomed Pharmacother. 2014;68:51-7 pubmed publisher
  • western blot; human
Broderick R, Rainey M, Santocanale C, Nasheuer H. Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage. FEBS J. 2013;280:4888-902 pubmed publisher
  • immunohistochemistry; rabbit; 1:150
Cladel N, Budgeon L, Hu J, Balogh K, Christensen N. Synonymous codon changes in the oncogenes of the cottontail rabbit papillomavirus lead to increased oncogenicity and immunogenicity of the virus. Virology. 2013;438:70-83 pubmed publisher
  • immunohistochemistry; rat; 1:200
Silva J, Ocarino N, Vieira A, Nascimento E, Serakides R. Effects of hypo- and hyperthyroidism on proliferation, angiogenesis, apoptosis and expression of COX-2 in the corpus luteum of female rats. Reprod Domest Anim. 2013;48:691-8 pubmed publisher
  • immunohistochemistry; mouse; 1:300
Souza C, Gamba C, Campos C, Lopes M, Ferreira M, Andrade S, et al. Carboplatin delays mammary cancer 4T1 growth in mice. Pathol Res Pract. 2013;209:24-9 pubmed publisher
  • immunohistochemistry; mouse; 1:300
Leite E, Souza C, Carvalho Júnior A, Coelho L, Lana A, Cassali G, et al. Encapsulation of cisplatin in long-circulating and pH-sensitive liposomes improves its antitumor effect and reduces acute toxicity. Int J Nanomedicine. 2012;7:5259-69 pubmed publisher
  • immunohistochemistry; mouse; 1:300
Maria de Souza C, Fonseca de Carvalho L, da Silva Vieira T, Cândida Araújo E Silva A, Teresa Paz Lopes M, Alves Neves Diniz Ferreira M, et al. Thalidomide attenuates mammary cancer associated-inflammation, angiogenesis and tumor growth in mice. Biomed Pharmacother. 2012;66:491-8 pubmed publisher
  • western blot; human
Broderick R, Ramadurai S, Toth K, Togashi D, Ryder A, Langowski J, et al. Cell cycle-dependent mobility of Cdc45 determined in vivo by fluorescence correlation spectroscopy. PLoS ONE. 2012;7:e35537 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Shin M, Pitot H, Lambert P. Pocket proteins suppress head and neck cancer. Cancer Res. 2012;72:1280-9 pubmed publisher
  • immunohistochemistry; dog; 1:200
Berlato D, Stewart J, Newton R, Maglennon G, Monti P, Flindall A, et al. Evaluation of minichromosome maintenance protein 7 as a prognostic marker in canine cutaneous mast cell tumours. Vet Comp Oncol. 2012;10:135-42 pubmed publisher
  • immunocytochemistry; human; 1:200
  • immunohistochemistry; human; 1:200
  • western blot; human; 1:200
Stelzer M, Pitot H, Liem A, Lee D, Kennedy G, Lambert P. Rapamycin inhibits anal carcinogenesis in two preclinical animal models. Cancer Prev Res (Phila). 2010;3:1542-51 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Jabbar S, Abrams L, Glick A, Lambert P. Persistence of high-grade cervical dysplasia and cervical cancer requires the continuous expression of the human papillomavirus type 16 E7 oncogene. Cancer Res. 2009;69:4407-14 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 7
Pedersen M, Larsen A, Pedersen D, Stoltenberg M, Penkowa M. Metallic gold treatment reduces proliferation of inflammatory cells, increases expression of VEGF and FGF, and stimulates cell proliferation in the subventricular zone following experimental traumatic brain injury. Histol Histopathol. 2009;24:573-86 pubmed publisher
  • immunohistochemistry; human; 1:200
Peev N, Tonchev A, Penkowa M, Kalevski S, Haritonov D, Chaldakov G. Cell proliferation index predicts relapse of brain metastases in non-irradiated patients. Acta Neurochir (Wien). 2008;150:1043-8; discussion 1048 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Balsitis S, Dick F, Dyson N, Lambert P. Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis. Cancer Res. 2006;66:9393-400 pubmed
  • immunohistochemistry; rat
  • western blot; rat
Com E, Rolland A, Guerrois M, Aubry F, Jégou B, Vallet Erdtmann V, et al. Identification, molecular cloning, and cellular distribution of the rat homolog of minichromosome maintenance protein 7 (MCM7) in the rat testis. Mol Reprod Dev. 2006;73:866-77 pubmed
  • western blot; mouse; 1:1000
Shen H, Sikorska M, Leblanc J, Walker P, Liu Q. Oxidative stress regulated expression of ubiquitin Carboxyl-terminal Hydrolase-L1: role in cell survival. Apoptosis. 2006;11:1049-59 pubmed
  • western blot; mouse
Kingsbury S, Loddo M, Fanshawe T, Obermann E, Prevost A, Stoeber K, et al. Repression of DNA replication licensing in quiescence is independent of geminin and may define the cell cycle state of progenitor cells. Exp Cell Res. 2005;309:56-67 pubmed
Wiebusch L, Uecker R, Hagemeier C. Human cytomegalovirus prevents replication licensing by inhibiting MCM loading onto chromatin. EMBO Rep. 2003;4:42-6 pubmed
product information
Product Type :
Antibody
Product Name :
MCM7 Monoclonal Antibody (47DC141 or DCS-141), Biotin
Catalog # :
MA5-14288
Quantity :
500µL
Price :
US 399.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Canine, Human, Mouse, Rat, Xenopus laevis
Applications :
Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): 0.5-1.0 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
Species :
Canine, Human, Mouse, Rat, Xenopus laevis
Clone :
47DC141 or DCS-141
Isotype :
IgG1
Storage :
4° C
Description :
hCDC47 is a human member of the MCM family, which allows DNA to replicate once per cell cycle. In quiescent cells, human MCM7 (hMCM7) mRNA is almost undetectable. Stimulation of cells to enter the cell cycle results in induction of hMCM7 expression. The hCDC47 protein expression and localization is found in nuclei of the proliferative components of normal lymph nodes, bone marrow, epidermis and mucosa. Malignant tumors from several organs contained more nuclear hCDC47-positive cells than their normal counterparts. These results indicate that hCDC47 may play a role in normal and neoplastic cell growth in vivo.
Immunogen :
Recombinant hCDC47 protein
Format :
Liquid
Applications w/Dilutions :
Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): 0.5-1.0 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL
Aliases :
CDC47 homolog, DNA replication licensing factor MCM7, homolog of S. cerevisiae Cdc47, minichromosome maintenance deficient 7
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
www.thermofisher.com
800-678-5599
headquarters: USA