CDKN2C Monoclonal Antibody (18P118 (DCS-118)) | Invitrogen MA5-14282 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CDKN2C Monoclonal Antibody (18P118 (DCS-118))

catalog :

MA5-14282

quantity :

500 µL

price :

US 496.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

18P118 (DCS-118)

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; mouse	Li Y, Pal R, Sung L, Feng H, Miao W, Cheng S, et al. An opposite effect of the CDK inhibitor, p18(INK4c) on embryonic stem cells compared with tumor and adult stem cells. PLoS ONE. 2012;7:e45212 pubmed publisher
immunohistochemistry - paraffin section; human; 1:20	Jung Y, Joo K, Seong D, Choi Y, Kong D, Kim Y, et al. Identification of prognostic biomarkers for glioblastomas using protein expression profiling. Int J Oncol. 2012;40:1122-32 pubmed publisher
western blot; human; 1:500	Wang X, Meyers C, Guo M, Zheng Z. Upregulation of p18Ink4c expression by oncogenic HPV E6 via p53-miR-34a pathway. Int J Cancer. 2011;129:1362-72 pubmed publisher
western blot; human	Wall S, Zhong Z, DeClerck Y. The cyclin-dependent kinase inhibitors p15INK4B and p21CIP1 are critical regulators of fibrillar collagen-induced tumor cell cycle arrest. J Biol Chem. 2007;282:24471-6 pubmed
	O Nions J, Allday M. Proliferation and differentiation in isogenic populations of peripheral B cells activated by Epstein-Barr virus or T cell-derived mitogens. J Gen Virol. 2004;85:881-95 pubmed

product information

Product Type :

Antibody

Product Name :

CDKN2C Monoclonal Antibody (18P118 (DCS-118))

Catalog # :

MA5-14282

Quantity :

500 µL

Price :

US 496.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Paraffin): 1:50, Immunoprecipitation: 1-2 µg/mL, Western Blot: 1-2 µg/mL

Species :

Human, Mouse

Clone :

18P118 (DCS-118)

Isotype :

IgG1

Storage :

4° C

Description :

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

Immunogen :

Purified recombinant p18INK4c protein

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50, Immunoprecipitation: 1-2 µg/mL, Western Blot: 1-2 µg/mL

Aliases :

C77269; CDK6 inhibitor p18; Cdkn2c; CDKN6; cyclin dependent kinase inhibitor 2C; cyclin-dependent inhibitor; cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; cyclin-dependent kinase 6 inhibitor p18; cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4); INK4c; p18; p18INK4c; p18-INK4c; p18-INK6