p130Cas Monoclonal Antibody (CAS-14 (35B-1A4)) | Invitrogen MA5-14276 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

p130Cas Monoclonal Antibody (CAS-14 (35B-1A4))

catalog :

MA5-14276

quantity :

500 uL

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CAS-14 (35B-1A4)

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human	Tornillo G, Elia A, Castellano I, Spadaro M, Bernabei P, Bisaro B, et al. p130Cas alters the differentiation potential of mammary luminal progenitors by deregulating c-Kit activity. Stem Cells. 2013;31:1422-33 pubmed publisher
immunohistochemistry; human	Konstantinovsky S, Davidson B, Reich R. Ezrin and BCAR1/p130Cas mediate breast cancer growth as 3-D spheroids. Clin Exp Metastasis. 2012;29:527-40 pubmed publisher
immunohistochemistry; human; 1:200	Konstantinovsky S, Smith Y, Zilber S, Tuft Stavnes H, Becker A, Nesland J, et al. Breast carcinoma cells in primary tumors and effusions have different gene array profiles. J Oncol. 2010;2010:969084 pubmed publisher
	Roberts K, Bhatia K, Stanton P, Lord R. Proteomic analysis of selected prognostic factors of breast cancer. Proteomics. 2004;4:784-92 pubmed

product information

Product Type :

Antibody

Product Name :

p130Cas Monoclonal Antibody (CAS-14 (35B-1A4))

Catalog # :

MA5-14276

Quantity :

500 uL

Price :

US 474.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Rat

Applications :

Immunohistochemistry (Paraffin): 1-2 ug/mL, Immunoprecipitation: 2 ug/mL, Western Blot: 1-2 ug/mL

Species :

Human, Rat

Clone :

CAS-14 (35B-1A4)

Isotype :

IgG1, kappa

Storage :

4 C

Description :

The p130Cas (Cas for Crk-associated substrate) is a common cellular target of phosphorylation signal via v-Crk and v-Src oncoproteins. p130Cas has a unique structure that contains a Src homology (SH)-3 domain followed by multiple YXXP motifs and a proline-rich regionp130Cas is implicated in a variety of biological processes including cell adhesion, cell migration, growth factor stimulation, cytokine receptor engagement and bacterial infection. Physiological functions of p130Cas include cardiovascular development, actin filament assembly and Src-induced cell transformation.

Immunogen :

Recombinant human p130Cas protein

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1-2 ug/mL, Immunoprecipitation: 2 ug/mL, Western Blot: 1-2 ug/mL

Aliases :

AI385681; BCA1; Bcar1; BCAR1 scaffold protein, Cas family member; BCAR1, Cas family scaffold protein; BCAR1, Cas family scaffolding protein; breast cancer anti-estrogen resistance 1; breast cancer anti-estrogen resistance protein 1; Cas; Cas scaffolding protein family member 1; CAS1; CASS1; CRKAS; CRK-associated substrate; Crk-associated substrate p130Cas; OTTHUMP00000174941; p130 Cas; P130CAS; p130Cas (pTyr410); p130Cas (pY410); p130Cas phospho; phospho p130Cas; v-crk-associated tyrosine kinase substrate

more info or order :

Invitrogen product webpage