MMP13 Monoclonal Antibody (LIPCO IID1) | Invitrogen MA5-14247 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MMP13 Monoclonal Antibody (LIPCO IID1)

catalog :

MA5-14247

quantity :

500 uL

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

LIPCO IID1

reactivity :

human, mouse, rat, chicken

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 23

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:350; fig 3a	Shi D, Shi G, Xie J, Du X, Yang H. MicroRNA-27a Inhibits Cell Migration and Invasion of Fibroblast-Like Synoviocytes by Targeting Follistatin-Like Protein 1 in Rheumatoid Arthritis. Mol Cells. 2016;39:611-8 pubmed publisher
western blot; rat	Ben David D, Livne E, Reznick A. The involvement of oxidants and NF-?B in cytokine-induced MMP-9 synthesis by bone marrow-derived osteoprogenitor cells. Inflamm Res. 2012;61:673-88 pubmed publisher
western blot; chicken	Patchigolla R, Knudson W, Schmid T. Matrix metalloproteinase-9 in a unique proteoglycan form in avian embryonic growth plate cartilage. Arch Biochem Biophys. 2012;520:42-50 pubmed publisher
western blot; human; 1:200	Moriya C, Jinnin M, Yamane K, Maruo K, Muchemwa F, Igata T, et al. Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC-? in normal human dermal fibroblasts. J Invest Dermatol. 2011;131:655-61 pubmed publisher
immunoprecipitation; human immunocytochemistry; human western blot; human	Ibaragi S, Shimo T, Iwamoto M, Hassan N, Kodama S, Isowa S, et al. Parathyroid hormone-related peptide regulates matrix metalloproteinase-13 gene expression in bone metastatic breast cancer cells. Anticancer Res. 2010;30:5029-36 pubmed
western blot; rat	Laragione T, Gulko P. mTOR regulates the invasive properties of synovial fibroblasts in rheumatoid arthritis. Mol Med. 2010;16:352-8 pubmed publisher
western blot; mouse	Kimura Y, Sumiyoshi M. French maritime pine bark (Pinus maritima Lam.) extract (Flavangenol) prevents chronic UVB radiation-induced skin damage and carcinogenesis in melanin-possessing hairless mice. Photochem Photobiol. 2010;86:955-63 pubmed publisher
western blot; mouse	Sumiyoshi M, Kimura Y. Effects of olive leaf extract and its main component oleuroepin on acute ultraviolet B irradiation-induced skin changes in C57BL/6J mice. Phytother Res. 2010;24:995-1003 pubmed publisher
western blot; mouse	Kim E, Jin X, Kim Y, Oh I, Kim J, Park C, et al. UV decreases the synthesis of free fatty acids and triglycerides in the epidermis of human skin in vivo, contributing to development of skin photoaging. J Dermatol Sci. 2010;57:19-26 pubmed publisher
western blot; mouse	Kimura Y, Sumiyoshi M. Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice. J Nutr. 2009;139:2079-86 pubmed publisher
western blot; rat; 1:50	de Aquino S, Guimaraes M, Stach Machado D, da Silva J, Spolidorio L, Rossa C. Differential regulation of MMP-13 expression in two models of experimentally induced periodontal disease in rats. Arch Oral Biol. 2009;54:609-17 pubmed publisher
western blot; mouse	Cheung C, Marchant D, Walker E, Luo Z, Zhang J, Yanagawa B, et al. Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice. Circulation. 2008;117:1574-82 pubmed publisher
western blot; mouse; 1:200	Montesano R, Carrozzino F, Soulie P. Low concentrations of transforming growth factor-beta-1 induce tubulogenesis in cultured mammary epithelial cells. BMC Dev Biol. 2007;7:7 pubmed
immunocytochemistry; mouse	Higashiyama R, Inagaki Y, Hong Y, Kushida M, Nakao S, Niioka M, et al. Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice. Hepatology. 2007;45:213-22 pubmed
western blot; mouse; 1:100	Shiomi N, Cui X, Yamamoto T, Saito T, Shuler C. Inhibition of SMAD2 expression prevents murine palatal fusion. Dev Dyn. 2006;235:1785-93 pubmed
western blot; rat	Popov Y, Patsenker E, Bauer M, Niedobitek E, Schulze Krebs A, Schuppan D. Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB. J Biol Chem. 2006;281:15090-8 pubmed
western blot; rat	Cheng X, Kuzuya M, Nakamura K, Liu Z, Di Q, Hasegawa J, et al. Mechanisms of the inhibitory effect of epigallocatechin-3-gallate on cultured human vascular smooth muscle cell invasion. Arterioscler Thromb Vasc Biol. 2005;25:1864-70 pubmed
	Zhang G, Zhang H, You W, Tang X, Li X, Gong Z. Therapeutic effect of Resveratrol in the treatment of osteoarthritis via the MALAT1/miR-9/NF-κB signaling pathway. Exp Ther Med. 2020;19:2343-2352 pubmed publisher
	Ji Q, Qiao X, Liu Y, Wang D, Yan J. Silencing of long‑chain non‑coding RNA GAS5 in osteoarthritic chondrocytes is mediated by targeting the miR‑34a/Bcl‑2 axis. Mol Med Rep. 2020;21:1310-1319 pubmed publisher
	Jia P, Zhang X, Zuo H, Lu X, Li L. Articular cartilage degradation is prevented by tanshinone IIA through inhibiting apoptosis and the expression of inflammatory cytokines. Mol Med Rep. 2017;16:6285-6289 pubmed publisher
	Galuppo P, Vettorazzi S, HÃ¶velmann J, Scholz C, Tuckermann J, Bauersachs J, et al. The glucocorticoid receptor in monocyte-derived macrophages is critical for cardiac infarct repair and remodeling. FASEB J. 2017;31:5122-5132 pubmed publisher
	Lechuga C, Hernández Nazará Z, Domínguez Rosales J, Morris E, Rincón A, Rivas Estilla A, et al. TGF-beta1 modulates matrix metalloproteinase-13 expression in hepatic stellate cells by complex mechanisms involving p38MAPK, PI3-kinase, AKT, and p70S6k. Am J Physiol Gastrointest Liver Physiol. 2004;287:G974-87 pubmed
	Netzel Arnett S, Mitola D, Yamada S, Chrysovergis K, Holmbeck K, Birkedal Hansen H, et al. Collagen dissolution by keratinocytes requires cell surface plasminogen activation and matrix metalloproteinase activity. J Biol Chem. 2002;277:45154-61 pubmed

product information

Product Type :

Antibody

Product Name :

MMP13 Monoclonal Antibody (LIPCO IID1)

Catalog # :

MA5-14247

Quantity :

500 uL

Price :

US 480.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Mouse, Rat

Applications :

Immunocytochemistry: 2 ug/mL, Immunoprecipitation: 2 ug/mL, Western Blot: 2 ug/mL

Species :

Mouse, Rat

Clone :

LIPCO IID1

Isotype :

IgG1, kappa

Storage :

4 C

Description :

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.

Immunogen :

Rat MMP-13 from BC-1 cells

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 ug/mL, Immunoprecipitation: 2 ug/mL, Western Blot: 2 ug/mL

Aliases :

cb1034; Clg; CLG3; Collagenase; collagenase 3; collagenase 3a; matrix metalloproteinase 13a; collagenase-1; Collagenase3; Collagenase-3; collagenase-3 precursor; interstitial collagenase; MANDP1; matrix metallo protease; matrix metallopeptidase 13; matrix metallopeptidase 13 (collagenase 3); matrix metallopeptidase 13a; matrix metallopeptidase 13a (collagenase 3); matrix metalloproteinase 13; matrix metalloproteinase 13 (collagenase 3); matrix metalloproteinase-13; matrix metalloproteinase-13; MMP-13; interstitial protein; MMP; Mmp1; MMP13; MMP-13; mmp13 protein; mmp13a; MMPLg; MMPLh; MMPs; Procollagenase 3; UMRCASE; ZFMMP13

more info or order :

Invitrogen product webpage