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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MMP13 Monoclonal Antibody (VIIIA2)
catalog :
MA5-14238
quantity :
500 uL
price :
US 480.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
VIIIA2
reactivity :
human, mouse, rat, domestic rabbit
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 51
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:50; tbl 2
Cid S, Eiró N, Gonzalez L, Béridze N, Vazquez J, Vizoso F. Expression and Clinical Significance of Metalloproteases and Their Inhibitors by Endothelial Cells From Invasive Breast Carcinomas. Clin Breast Cancer. 2016;16:e83-91 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:250; loading ...; tbl 1
Andrade A, Santos E, Carmo A, Freitas R, Galvão H. Analysis of tryptase-positive mast cells and immunoexpression of MMP-9 and MMP-13 in periapical lesions. Int Endod J. 2017;50:446-454 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 5
Zhang Y, Sheu T, Hoak D, Shen J, Hilton M, Zuscik M, et al. CCN1 Regulates Chondrocyte Maturation and Cartilage Development. J Bone Miner Res. 2016;31:549-59 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:20; fig 6
Salaün M, Peng J, Hensley H, Roder N, Flieder D, Houlle Crépin S, et al. MMP-13 In-Vivo Molecular Imaging Reveals Early Expression in Lung Adenocarcinoma. PLoS ONE. 2015;10:e0132960 pubmed publisher
  • immunohistochemistry; human; 1:25
Kim G, Lee J, Choi Y, Lee K, Lee J, Nam J, et al. Expression of matrix metalloproteinases and their inhibitors in different immunohistochemical-based molecular subtypes of breast cancer. BMC Cancer. 2014;14:959 pubmed publisher
  • immunohistochemistry; human; 1:150
Folgueira M, Maistro S, Katayama M, Roela R, Mundim F, Nanogaki S, et al. Markers of breast cancer stromal fibroblasts in the primary tumour site associated with lymph node metastasis: a systematic review including our case series. Biosci Rep. 2013;33: pubmed publisher
  • immunohistochemistry; human; 1:150
Mehra R, Zhu F, Yang D, Cai K, Weaver J, Singh M, et al. Quantification of excision repair cross-complementing group 1 and survival in p16-negative squamous cell head and neck cancers. Clin Cancer Res. 2013;19:6633-43 pubmed publisher
  • immunohistochemistry; human; 1:50
Suárez Roa M, Asbun Bojalil J, Ruiz Godoy L, Meneses García A. Immunoexpression of matrix metalloproteinases and their inhibitors in different areas of oral squamous cell carcinoma. Aust Dent J. 2012;57:300-7 pubmed publisher
  • immunohistochemistry; human
El Hawary A, Yassin E, Khater A, Abdelgaber S. Expression of matrix metalloproteinase-13 and Ki-67 in nonmelanoma skin cancer in xeroderma pigmentosum and non-xeroderma pigmentosum. Am J Dermatopathol. 2013;35:45-9 pubmed publisher
  • immunohistochemistry; rat; 1:20
Hammad S, El Hawary Y, El Hawary A. The use of different analgesics in orthodontic tooth movements. Angle Orthod. 2012;82:820-6 pubmed publisher
  • western blot; mouse; 1:500
Shin M, Seo J, Kim Y, Kim K, Chung J. Chronic heat treatment causes skin wrinkle formation and oxidative damage in hairless mice. Mech Ageing Dev. 2012;133:92-8 pubmed publisher
  • immunohistochemistry; mouse
Kondo E, Yasoda A, Tsuji T, Fujii T, Miura M, Kanamoto N, et al. Skeletal analysis of the long bone abnormality (lbab/lbab) mouse, a novel chondrodysplastic C-type natriuretic peptide mutant. Calcif Tissue Int. 2012;90:307-18 pubmed publisher
  • immunohistochemistry; human
Lee S, Park S, Kim S, Choi E. Expression of matrix metalloproteinases and their inhibitors in squamous cell carcinoma of the tonsil and their clinical significance. Clin Exp Otorhinolaryngol. 2011;4:88-94 pubmed publisher
  • immunohistochemistry; domestic rabbit; 1:25
Shirai T, Kobayashi M, Nishitani K, Satake T, Kuroki H, Nakagawa Y, et al. Chondroprotective effect of alendronate in a rabbit model of osteoarthritis. J Orthop Res. 2011;29:1572-7 pubmed publisher
  • immunohistochemistry; human; 1:100
Escaff S, Fernández J, Gonzalez L, Suarez A, Gonzalez Reyes S, Gonzalez J, et al. Collagenase-3 expression by tumor cells and gelatinase B expression by stromal fibroblast-like cells are associated with biochemical recurrence after radical prostatectomy in patients with prostate cancer. World J Urol. 2011;29:657-63 pubmed publisher
  • immunohistochemistry; human; 1:20
Leonardi R, Matthews J, Caltabiano R, Greco M, Lombardo C, Loreto C, et al. MMP-13 expression in keratocyst odontogenic tumour associated with NBCCS and sporadic keratocysts. Oral Dis. 2010;16:795-800 pubmed publisher
  • immunohistochemistry; human; 1:100
Gonzalez L, Junquera S, del Casar J, Gonzalez L, Marín L, Gonzalez Reyes S, et al. Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast. Hum Pathol. 2010;41:980-9 pubmed publisher
  • immunohistochemistry; human; 1:100
Escaff S, Fernandez J, Gonzalez L, Suarez A, Gonzalez Reyes S, Gonzalez J, et al. Study of matrix metalloproteinases and their inhibitors in prostate cancer. Br J Cancer. 2010;102:922-9 pubmed publisher
  • immunohistochemistry; human; 1:100
Gonzalez L, Gonzalez Reyes S, Junquera S, Marin L, Gonzalez L, del Casar J, et al. Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events. J Cancer Res Clin Oncol. 2010;136:1313-21 pubmed publisher
  • immunohistochemistry; human; 1:100
del Casar J, Carreño G, Gonzalez L, Junquera S, Gonzalez Reyes S, Gonzalez J, et al. Expression of metalloproteases and their inhibitors in primary tumors and in local recurrences after mastectomy for breast cancer. J Cancer Res Clin Oncol. 2010;136:1049-58 pubmed publisher
  • immunohistochemistry; human; 1:100
del Casar J, Gonzalez Reyes S, Gonzalez L, Gonzalez J, Junquera S, Bongera M, et al. Expression of metalloproteases and their inhibitors in different histological types of breast cancer. J Cancer Res Clin Oncol. 2010;136:811-9 pubmed publisher
  • immunohistochemistry; human; 1:100
Arufe M, de la Fuente A, Fuentes Boquete I, de Toro F, Blanco F. Differentiation of synovial CD-105(+) human mesenchymal stem cells into chondrocyte-like cells through spheroid formation. J Cell Biochem. 2009;108:145-55 pubmed publisher
  • immunohistochemistry; human; 1:100
del Casar J, Gonzalez L, Alvarez E, Junquera S, Marin L, Gonzalez L, et al. Comparative analysis and clinical value of the expression of metalloproteases and their inhibitors by intratumor stromal fibroblasts and those at the invasive front of breast carcinomas. Breast Cancer Res Treat. 2009;116:39-52 pubmed publisher
  • immunohistochemistry; rat; 1:100
Zhang M, Feng D, Shao P, Sun T, Wang L, Yang B. Nifedipine regulated periodontal ligament remodeling: an experimental study in rats. Acta Odontol Scand. 2008;66:327-33 pubmed publisher
  • immunohistochemistry; mouse; 5 ug/ml
Aikawa Y, Morimoto K, Yamamoto T, Chaki H, Hashiramoto A, Narita H, et al. Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1. Nat Biotechnol. 2008;26:817-23 pubmed publisher
  • immunohistochemistry; human
Zyada M, Shamaa A. Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?. Diagn Pathol. 2008;3:26 pubmed publisher
  • immunohistochemistry; human; 1:150
Zhang B, Cao X, Liu Y, Cao W, Zhang F, Zhang S, et al. Tumor-derived matrix metalloproteinase-13 (MMP-13) correlates with poor prognoses of invasive breast cancer. BMC Cancer. 2008;8:83 pubmed publisher
  • immunohistochemistry; human; 1:10
Boyd S, Tolvanen K, Virolainen S, Kuivanen T, Kyllönen L, Saarialho Kere U. Differential expression of stromal MMP-1, MMP-9 and TIMP-1 in basal cell carcinomas of immunosuppressed patients and controls. Virchows Arch. 2008;452:83-90 pubmed
  • immunohistochemistry; human; 1:100
Gonzalez L, Pidal I, Junquera S, Corte M, Vazquez J, Rodriguez J, et al. Overexpression of matrix metalloproteinases and their inhibitors in mononuclear inflammatory cells in breast cancer correlates with metastasis-relapse. Br J Cancer. 2007;97:957-63 pubmed
  • immunohistochemistry; domestic rabbit; 1:1000
Asikainen A, Hagstrom J, Sorsa T, Noponen J, Kellomaki M, Juuti H, et al. Soft tissue reactions to bioactive glass 13-93 combined with chitosan. J Biomed Mater Res A. 2007;83:530-7 pubmed
  • immunohistochemistry; rat; 1:20
Leonardi R, Talic N, Loreto C. MMP-13 (collagenase 3) immunolocalisation during initial orthodontic tooth movement in rats. Acta Histochem. 2007;109:215-20 pubmed
  • immunohistochemistry; human; 1:100
Vizoso F, Gonzalez L, Corte M, Rodriguez J, Vazquez J, Lamelas M, et al. Study of matrix metalloproteinases and their inhibitors in breast cancer. Br J Cancer. 2007;96:903-11 pubmed
  • immunohistochemistry; human; 1:10
Kuivanen T, Ahokas K, Virolainen S, Jahkola T, Hölttä E, Saksela O, et al. MMP-21 is upregulated at early stages of melanoma progression but disappears with more aggressive phenotype. Virchows Arch. 2005;447:954-60 pubmed
Lou Y, Song F, Kang Y, Xu Y. Periodic Mechanical Stress Inhibits the Development of Osteoarthritis via Regulating ATF3-Akt Axis. J Inflamm Res. 2023;16:5613-5628 pubmed publisher
Zhao S, Xiu G, Wang J, Wen Y, Lu J, Wu B, et al. Engineering exosomes derived from subcutaneous fat MSCs specially promote cartilage repair as miR-199a-3p delivery vehicles in Osteoarthritis. J Nanobiotechnology. 2023;21:341 pubmed publisher
Zhao S, Liu Y, Wang J, Wen Y, Wu B, Yang D, et al. ADSCs increase the autophagy of chondrocytes through decreasing miR-7-5p in Osteoarthritis rats by targeting ATG4A. Int Immunopharmacol. 2023;120:110390 pubmed publisher
Eiró N, Medina A, Gonzalez L, Fraile M, Palacios A, Escaf S, et al. Evaluation of Matrix Metalloproteases by Artificial Intelligence Techniques in Negative Biopsies as New Diagnostic Strategy in Prostate Cancer. Int J Mol Sci. 2023;24: pubmed publisher
Oranger A, Zerlotin R, Buccoliero C, Sanesi L, Storlino G, Schipani E, et al. Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing. Int J Mol Sci. 2023;24: pubmed publisher
Hayward M, Allen M, Gomm J, Goulding I, Thompson C, Knight M, et al. Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion. NPJ Breast Cancer. 2022;8:109 pubmed publisher
He T, Pang S, Wang H, Yun H, Hao X, Jia L, et al. Drugging the circadian clock feedback cycle to ameliorate cartilage degeneration. FEBS J. 2022;289:6643-6658 pubmed publisher
He C, Clark K, Tan J, Zhou H, Tuan R, Lin H, et al. Modeling early changes associated with cartilage trauma using human-cell-laden hydrogel cartilage models. Stem Cell Res Ther. 2022;13:400 pubmed publisher
Lee M, Kim H, Chung H, Kim D, Lee J. Low-Molecular-Weight Collagen Peptide Ameliorates Osteoarthritis Progression through Promoting Extracellular Matrix Synthesis by Chondrocytes in a Rabbit Anterior Cruciate Ligament Transection Model. J Microbiol Biotechnol. 2021;31:1401-1408 pubmed publisher
Rowswell Turner R, Singh R, Urh A, Yano N, Kim K, Khazan N, et al. HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression. J Immunol. 2021;206:2478-2488 pubmed publisher
Hoogmartens J, Hens E, Engelborghs S, De Deyn P, van der Zee J, Van Broeckhoven C, et al. Investigation of the role of matrix metalloproteinases in the genetic etiology of Alzheimer's disease. Neurobiol Aging. 2021;104:105.e1-105.e6 pubmed publisher
Park H, Hong J, Yin Y, Joo Y, Kim Y, Shin J, et al. TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model. Sci Rep. 2020;10:17451 pubmed publisher
Gerashchenko T, Zolotaryova S, Kiselev A, Tashireva L, Novikov N, Krakhmal N, et al. The Activity of KIF14, Mieap, and EZR in a New Type of the Invasive Component, Torpedo-Like Structures, Predetermines the Metastatic Potential of Breast Cancer. Cancers (Basel). 2020;12: pubmed publisher
Zhang G, Zhang H, You W, Tang X, Li X, Gong Z. Therapeutic effect of Resveratrol in the treatment of osteoarthritis via the MALAT1/miR-9/NF-κB signaling pathway. Exp Ther Med. 2020;19:2343-2352 pubmed publisher
Bozzelli P, Caccavano A, Avdoshina V, Mocchetti I, Wu J, Conant K. Increased matrix metalloproteinase levels and perineuronal net proteolysis in the HIV-infected brain; relevance to altered neuronal population dynamics. Exp Neurol. 2020;323:113077 pubmed publisher
Bozzelli P, Yin T, Avdoshina V, Mocchetti I, CONANT K, Maguire Zeiss K. HIV-1 Tat promotes astrocytic release of CCL2 through MMP/PAR-1 signaling. Glia. 2019;67:1719-1729 pubmed publisher
Ismail T, Bennett D, Platt Higgins A, Al Medhity M, Barraclough R, Rudland P. S100A4 Elevation Empowers Expression of Metastasis Effector Molecules in Human Breast Cancer. Cancer Res. 2017;77:780-789 pubmed publisher
Mirando A, Liu Z, Moore T, Lang A, Kohn A, Osinski A, et al. RBP-J?-dependent Notch signaling is required for murine articular cartilage and joint maintenance. Arthritis Rheum. 2013;65:2623-33 pubmed publisher
product information
Product Type :
Antibody
Product Name :
MMP13 Monoclonal Antibody (VIIIA2)
Catalog # :
MA5-14238
Quantity :
500 uL
Price :
US 480.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Western Blot: 2-4 ug/mL
Species :
Human, Mouse
Clone :
VIIIA2
Isotype :
IgG1, kappa
Storage :
4 C
Description :
MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.
Immunogen :
Human recombinant collagenase-3 protein
Format :
Liquid
Applications w/Dilutions :
Western Blot: 2-4 ug/mL
Aliases :
cb1034; Clg; CLG3; Collagenase; collagenase 3; collagenase 3a; matrix metalloproteinase 13a; collagenase-1; Collagenase3; Collagenase-3; collagenase-3 precursor; interstitial collagenase; MANDP1; matrix metallo protease; matrix metallopeptidase 13; matrix metallopeptidase 13 (collagenase 3); matrix metallopeptidase 13a; matrix metallopeptidase 13a (collagenase 3); matrix metalloproteinase 13; matrix metalloproteinase 13 (collagenase 3); matrix metalloproteinase-13; matrix metalloproteinase-13; MMP-13; interstitial protein; MMP; Mmp1; MMP13; MMP-13; mmp13 protein; mmp13a; MMPLg; MMPLh; MMPs; Procollagenase 3; UMRCASE; ZFMMP13
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA