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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MMP2 Monoclonal Antibody (VB3), Biotin
catalog :
MA5-14183
quantity :
500 uL
price :
US 524.00
clonality :
monoclonal
host :
mouse
conjugate :
biotin
clone name :
VB3
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
more info or order :
Invitrogen product webpage
citations: 34
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:100
Lin C, Jin J, Yu C, Tsai W. Expression of LGR8 and related biomarkers in hepatocellular carcinoma: correlation with clinicopathological parameters. Chin J Physiol. 2011;54:161-8 pubmed
  • western blot; mouse; 1:600
Olsen C, Moreira J, Lukanidin E, Ambartsumian N. Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts. BMC Cancer. 2010;10:444 pubmed publisher
  • immunohistochemistry; human; 1:500
Kim H, Chae S, Woo K, Kim Y. Expression of matrix metalloproteinase (MMP)-2, MMP-9, and tissue inhibitor of MMP (TIMP)-1 in conjunctival melanomas and clinical implications. Jpn J Ophthalmol. 2010;54:221-6 pubmed publisher
  • immunohistochemistry; human; 1:50
Gonzalez L, Junquera S, del Casar J, Gonzalez L, Marín L, Gonzalez Reyes S, et al. Immunohistochemical study of matrix metalloproteinases and their inhibitors in pure and mixed invasive and in situ ductal carcinomas of the breast. Hum Pathol. 2010;41:980-9 pubmed publisher
  • immunohistochemistry; human; 1:50
Escaff S, Fernandez J, Gonzalez L, Suarez A, Gonzalez Reyes S, Gonzalez J, et al. Study of matrix metalloproteinases and their inhibitors in prostate cancer. Br J Cancer. 2010;102:922-9 pubmed publisher
  • immunohistochemistry; human; 1:50
Gonzalez L, Gonzalez Reyes S, Junquera S, Marin L, Gonzalez L, del Casar J, et al. Expression of metalloproteases and their inhibitors by tumor and stromal cells in ductal carcinoma in situ of the breast and their relationship with microinvasive events. J Cancer Res Clin Oncol. 2010;136:1313-21 pubmed publisher
  • immunohistochemistry; human; 1:50
del Casar J, Carreño G, Gonzalez L, Junquera S, Gonzalez Reyes S, Gonzalez J, et al. Expression of metalloproteases and their inhibitors in primary tumors and in local recurrences after mastectomy for breast cancer. J Cancer Res Clin Oncol. 2010;136:1049-58 pubmed publisher
  • immunohistochemistry; human; 1:50
del Casar J, Gonzalez Reyes S, Gonzalez L, Gonzalez J, Junquera S, Bongera M, et al. Expression of metalloproteases and their inhibitors in different histological types of breast cancer. J Cancer Res Clin Oncol. 2010;136:811-9 pubmed publisher
  • immunohistochemistry; human
Wang L, Madigan M, Chen H, Liu F, Patterson K, Beretov J, et al. Expression of urokinase plasminogen activator and its receptor in advanced epithelial ovarian cancer patients. Gynecol Oncol. 2009;114:265-72 pubmed publisher
  • immunohistochemistry; human
Jia J, Wang C, Shi Z, Zhao J, Jia Y, Zhao Hui Z, et al. Inhibitory effect of CD147/HAb18 monoclonal antibody on cartilage erosion and synovitis in the SCID mouse model for rheumatoid arthritis. Rheumatology (Oxford). 2009;48:721-6 pubmed publisher
  • western blot; human
Afaq F, Zaid M, Khan N, Dreher M, Mukhtar H. Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin. Exp Dermatol. 2009;18:553-61 pubmed publisher
  • immunohistochemistry; human; 1:100
Lin C, Chao T, Yu C, Yu M, Jin J. The expression of six biomarkers in the four most common ovarian cancers: correlation with clinicopathological parameters. APMIS. 2009;117:162-75 pubmed publisher
  • immunohistochemistry; human; 1:50
del Casar J, Gonzalez L, Alvarez E, Junquera S, Marin L, Gonzalez L, et al. Comparative analysis and clinical value of the expression of metalloproteases and their inhibitors by intratumor stromal fibroblasts and those at the invasive front of breast carcinomas. Breast Cancer Res Treat. 2009;116:39-52 pubmed publisher
  • immunohistochemistry; human
Miyata Y, Sagara Y, Kanda S, Hayashi T, Kanetake H. Phosphorylated hepatocyte growth factor receptor/c-Met is associated with tumor growth and prognosis in patients with bladder cancer: correlation with matrix metalloproteinase-2 and -7 and E-cadherin. Hum Pathol. 2009;40:496-504 pubmed publisher
  • western blot; human
Lin C, Hou W, Shen S, Juan S, Ko C, Wang L, et al. Quercetin inhibition of tumor invasion via suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells. Carcinogenesis. 2008;29:1807-15 pubmed publisher
  • immunohistochemistry; human; 1:100
Shaco Levy R, Sharabi S, Piura B, Sion Vardy N. MMP-2, TIMP-1, E-cadherin, and beta-catenin expression in endometrial serous carcinoma compared with low-grade endometrial endometrioid carcinoma and proliferative endometrium. Acta Obstet Gynecol Scand. 2008;87:868-74 pubmed publisher
  • western blot; human
Guo Y, Rubin E, Xie J, Zi X, Hoang B. Dominant negative LRP5 decreases tumorigenicity and metastasis of osteosarcoma in an animal model. Clin Orthop Relat Res. 2008;466:2039-45 pubmed publisher
  • immunohistochemistry; human
  • western blot; human
Arbab A, Janic B, Knight R, Anderson S, Pawelczyk E, Rad A, et al. Detection of migration of locally implanted AC133+ stem cells by cellular magnetic resonance imaging with histological findings. FASEB J. 2008;22:3234-46 pubmed publisher
  • western blot; human; 1:500
Lin C, Shen S, Hou W, Yang L, Chen Y. Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9. Mol Cancer Ther. 2008;7:1195-206 pubmed publisher
  • immunohistochemistry; human; 1:20
Bruggink A, Van Oosterhout M, de Jonge N, Cleutjens J, van Wichen D, van Kuik J, et al. Type IV collagen degradation in the myocardial basement membrane after unloading of the failing heart by a left ventricular assist device. Lab Invest. 2007;87:1125-37 pubmed
  • immunohistochemistry; human; 1:50
Gonzalez L, Pidal I, Junquera S, Corte M, Vazquez J, Rodriguez J, et al. Overexpression of matrix metalloproteinases and their inhibitors in mononuclear inflammatory cells in breast cancer correlates with metastasis-relapse. Br J Cancer. 2007;97:957-63 pubmed
  • immunohistochemistry; human; 1:100
Cho Y, Lee W, Song S, Shin H, Yun S, Chun H. Matrix metalloproteinase-9 activity is associated with poor prognosis in T3-T4 node-negative colorectal cancer. Hum Pathol. 2007;38:1603-10 pubmed
  • western blot; human
Muroi Y, Kakudo K, Nakata K. Effects of compressive loading on human synovium-derived cells. J Dent Res. 2007;86:786-91 pubmed
  • immunohistochemistry; human; 1:50
Lee S, Park K, Choi J, Kwon J, Lee D, Shin M, et al. A prospective, randomized, placebo-controlled, double-blinded, and split-face clinical study on LED phototherapy for skin rejuvenation: clinical, profilometric, histologic, ultrastructural, and biochemical evaluations and comparison of three differen. J Photochem Photobiol B. 2007;88:51-67 pubmed
  • western blot; human; 5 ug/ml
Zhou J, Olson B, Windsor L. Nicotine increases the collagen-degrading ability of human gingival fibroblasts. J Periodontal Res. 2007;42:228-35 pubmed
  • immunohistochemistry; human; 1:50
Vizoso F, Gonzalez L, Corte M, Rodriguez J, Vazquez J, Lamelas M, et al. Study of matrix metalloproteinases and their inhibitors in breast cancer. Br J Cancer. 2007;96:903-11 pubmed
  • immunohistochemistry; human; 1:50
Lin Y, Han L, Kamat A, Merritt W, Landen C, Deavers M, et al. EphA2 overexpression is associated with angiogenesis in ovarian cancer. Cancer. 2007;109:332-40 pubmed
  • immunohistochemistry; human; 1:100
Rönkkö S, Rekonen P, Kaarniranta K, Puustjarvi T, Teräsvirta M, Uusitalo H. Matrix metalloproteinases and their inhibitors in the chamber angle of normal eyes and patients with primary open-angle glaucoma and exfoliation glaucoma. Graefes Arch Clin Exp Ophthalmol. 2007;245:697-704 pubmed
  • immunohistochemistry; human; 1:200
Sier C, Zuidwijk K, Zijlmans H, Hanemaaijer R, Mulder Stapel A, Prins F, et al. EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma. Int J Cancer. 2006;118:2991-8 pubmed
Okada Y, Eibl G, Guha S, Duffy J, Reber H, Hines O. Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells. Clin Exp Metastasis. 2004;21:285-92 pubmed
Duxbury M, Ito H, Zinner M, Ashley S, Whang E. Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasiveness. Biochem Biophys Res Commun. 2004;320:1096-102 pubmed
Duxbury M, Ito H, Benoit E, Zinner M, Ashley S, Whang E. Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. Oncogene. 2004;23:5834-42 pubmed
Hashimoto T, Wen G, Lawton M, Boudreau N, Bollen A, Yang G, et al. Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations. Stroke. 2003;34:925-31 pubmed
Ghorpade A, Persidskaia R, Suryadevara R, Che M, Liu X, Persidsky Y, et al. Mononuclear phagocyte differentiation, activation, and viral infection regulate matrix metalloproteinase expression: implications for human immunodeficiency virus type 1-associated dementia. J Virol. 2001;75:6572-83 pubmed
product information
Product Type :
Antibody
Product Name :
MMP2 Monoclonal Antibody (VB3), Biotin
Catalog # :
MA5-14183
Quantity :
500 uL
Price :
US 524.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Human
Applications :
Immunocytochemistry: Assay-dependent, Immunoprecipitation: 2 ug/mL, Western Blot: 1-2 ug/mL
Species :
Human
Clone :
VB3
Isotype :
IgG1, kappa
Storage :
4 C
Description :
MMP (matrix metalloproteinase) are proteolytic enzymes capable of degrading connective tissue components. MMP have a common mode of activation, a conserved amino acid sequence in the putative metal binding-active site region, and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). MMPa and TIMPs play a significant role in regulating angiogenesis. MMP2 is synthesized as a 631 amino acid proenzyme which is activated by cleavage of the first 80 amino acids, and contains the basic structure of propeptide, catalytic, and hemopexin domains. The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane-bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc-binding site characterizes the structure of the MMPs. Functionally, MMP2 is involved in tissue remodeling. Mutations in MMP-2 gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP-2 have been found.
Immunogen :
Human native 72kDa MMP-2
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: Assay-dependent, Immunoprecipitation: 2 ug/mL, Western Blot: 1-2 ug/mL
Aliases :
72 kDa gelatinase; 72 kDa type IV collagenase; 72 kDa type IV collagenase isoform a preproprotein; 72kD gelatinase; 72kD type IV collagenase; 72kDa gelatinase; 72kDa type IV collagenase; CLG 4A; CLG4; CLG4A; Collagenase; collagenase type IV-A; endopeptidase; GelA; gelatinase A; Gelatinase alpha; Mat; matrix metallo protease; matrix metallopeptidase 2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloprotease 2; matrix metalloproteinase; matrix metalloproteinase 2; matrix metalloproteinase 2 (72 KDa type IV collagenase); matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); matrix metalloproteinase-2; matrix metalloproteinase-II; MMP; MMP2; MMP-2; MMP-2 protein; MMP-II; MMPs; MONA; neutrophil gelatinase; PEX; prepro-72kDa matrix metalloproteinase; Progelatinase A; TBE1; TBE-1; wu:fa99h12; wu:fk89d01
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA