Tyrosinase Monoclonal Antibody (T311) | Invitrogen MA5-14177 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tyrosinase Monoclonal Antibody (T311)

catalog :

MA5-14177

quantity :

500 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

T311

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 28

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 1d	Perotti V, Baldassari P, Molla A, Vegetti C, Bersani I, Maurichi A, et al. NFATc2 is an intrinsic regulator of melanoma dedifferentiation. Oncogene. 2016;35:2862-72 pubmed publisher
western blot; human	Abad S, Wieërs G, Colau D, Wildmann C, Delair E, Dhote R, et al. Absence of recognition of common melanocytic antigens by T cells isolated from the cerebrospinal fluid of a Vogt-Koyanagi-Harada patient. Mol Vis. 2014;20:956-69 pubmed
immunohistochemistry; human; 1:100	Alaggio R, Cecchetto G, Martignoni G, Bisogno G, Cheng L, Sperli D, et al. Malignant perivascular epithelioid cell tumor in children: description of a case and review of the literature. J Pediatr Surg. 2012;47:e31-40 pubmed publisher
immunohistochemistry; human	Manganoni A, Rossi M, Sala R, Venturini M, Sereni E, Ungari M, et al. Dermoscopic, histological and immunohistochemical evaluation of cancerous features in acquired melanocytic nevi that have been repeatedly exposed to UVA or UVB. Exp Dermatol. 2012;21:86-90 pubmed publisher
immunohistochemistry - paraffin section; human; tbl 4	Tjin E, Konijnenberg D, Krebbers G, Mallo H, Drijfhout J, Franken K, et al. T-cell immune function in tumor, skin, and peripheral blood of advanced stage melanoma patients: implications for immunotherapy. Clin Cancer Res. 2011;17:5736-47 pubmed publisher
ELISA; human	Zhang H, Fu T, McGettigan S, Kumar S, Liu S, Speicher D, et al. IL-8 and cathepsin B as melanoma serum biomarkers. Int J Mol Sci. 2011;12:1505-18 pubmed publisher
western blot; human	Ho H, Kapadia R, Al Tahan S, Ahmad S, Ganesan A. WIPI1 coordinates melanogenic gene transcription and melanosome formation via TORC1 inhibition. J Biol Chem. 2011;286:12509-23 pubmed publisher
immunohistochemistry; human; 1:100	Petersson F, Michal M, Vanecek T, Hora M, Trivunić S, Halbhuber Z, et al. Bilateral renal tumors; conventional clear cell carcinoma and contralateral t(6;11)/t(X;17)-like tumor Histomorphologic, immunohistochemical, ultrastructural and molecular genetic studies including the report of a novel mutation in the VHL gene. Ann Diagn Pathol. 2011;15:362-9 pubmed publisher
immunocytochemistry; human; 1:50	Selvan S, Carbonell D, Fowler A, Beatty A, Ravindranath M, Dillman R. Establishment of stable cell lines for personalized melanoma cell vaccine. Melanoma Res. 2010;20:280-92 pubmed publisher
immunohistochemistry; human	Chen N, Hu Y, Li W, Eisinger M, Seiberg M, Lin C. The role of keratinocyte growth factor in melanogenesis: a possible mechanism for the initiation of solar lentigines. Exp Dermatol. 2010;19:865-72 pubmed publisher
immunohistochemistry; human; 1:100	Kacerovska D, Michal M, Sosna B, Cempirkova D, Ambrus M, Richtr P, et al. Carcinoid-like pattern in melanoma: report of 4 cases. Am J Dermatopathol. 2009;31:542-50 pubmed publisher
immunocytochemistry; human; 1:50	Vossmerbaeumer U, Ohnesorge S, Kuehl S, Haapalahti M, Kluter H, Jonas J, et al. Retinal pigment epithelial phenotype induced in human adipose tissue-derived mesenchymal stromal cells. Cytotherapy. 2009;11:177-88 pubmed publisher
immunohistochemistry; human	Hasegawa J, Goto Y, Murata H, Takata M, Saida T, Imokawa G. Downregulated melanogenic paracrine cytokine linkages in hypopigmented palmoplantar skin. Pigment Cell Melanoma Res. 2008;21:687-99 pubmed
immunocytochemistry; human; 1:2000 western blot; human; 1:2000	Hasegawa T, Treis A, Patenge N, Fiesel F, Springer W, Kahle P. Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways. J Neurochem. 2008;105:1700-15 pubmed publisher
immunohistochemistry; human	Michal M, Kazakov D, Sima R, Vanecek T. Primitive small cell tumor with epithelial, gangliocytic, neuroendocrine, and mesenchymal differentiation: report of 2 cases. Int J Surg Pathol. 2007;15:429-36 pubmed
flow cytometry; human	Yuan J, Kendle R, Ireland J, Heller G, Sadelain M, Young J, et al. Scalable expansion of potent genetically modified human langerhans cells in a closed system for clinical applications. J Immunother. 2007;30:634-43 pubmed
immunocytochemistry; human; 1:200	Julien S, Kociok N, Kreppel F, Kopitz J, Kochanek S, Biesemeier A, et al. Tyrosinase biosynthesis and trafficking in adult human retinal pigment epithelial cells. Graefes Arch Clin Exp Ophthalmol. 2007;245:1495-505 pubmed
immunohistochemistry; human	Luiten R, Kueter E, Mooi W, Gallee M, Rankin E, Gerritsen W, et al. Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients. J Clin Oncol. 2005;23:8978-91 pubmed
immunohistochemistry; human; 1:50	Sensi M, Nicolini G, Zanon M, Colombo C, Molla A, Bersani I, et al. Immunogenicity without immunoselection: a mutant but functional antioxidant enzyme retained in a human metastatic melanoma and targeted by CD8(+) T cells with a memory phenotype. Cancer Res. 2005;65:632-40 pubmed
immunoprecipitation; human immunocytochemistry; human; 1:250 western blot; human; 1:200	Popescu C, Paduraru C, Dwek R, Petrescu S. Soluble tyrosinase is an endoplasmic reticulum (ER)-associated degradation substrate retained in the ER by calreticulin and BiP/GRP78 and not calnexin. J Biol Chem. 2005;280:13833-40 pubmed
	Guo M, Wu Q, Lai Q, Wang X, Bai P, Fung K, et al. A prepared platelet-rich plasma extract, namely Self-Growth Colony, inhibits melanogenesis by down-regulating microphthalmia-associated transcription factor in skin melanocyte. J Cosmet Dermatol. 2021;20:3278-3288 pubmed publisher
	Lawana V, Um S, Rochet J, Turesky R, Shannahan J, Cannon J. Neuromelanin Modulates Heterocyclic Aromatic Amine-Induced Dopaminergic Neurotoxicity. Toxicol Sci. 2020;173:171-188 pubmed publisher
	Otręba M, Pajor M, Warncke J. Antimelanoma activity of perphenazine and prochlorperazine in human COLO829 and C32 cell lines. Naunyn Schmiedebergs Arch Pharmacol. 2019;: pubmed publisher
	Scarparo A, Sumida D, Patrão M, Avellar M, Visconti M, Maria de Lauro Castrucci A. Catecholamine effects on human melanoma cells evoked by alpha1-adrenoceptors. Arch Dermatol Res. 2004;296:112-9 pubmed
	van Oijen M, Bins A, Elias S, Sein J, Weder P, de Gast G, et al. On the role of melanoma-specific CD8+ T-cell immunity in disease progression of advanced-stage melanoma patients. Clin Cancer Res. 2004;10:4754-60 pubmed
	Glazyrin A, Kan Mitchell J, Mitchell M. Analysis of in vitro immunization: generation of cytotoxic T-lymphocytes against allogeneic melanoma cells with tumor lysate-loaded or tumor RNA-transfected antigen-presenting cells. Cancer Immunol Immunother. 2003;52:171-8 pubmed
	Sheffield M, Yee H, Dorvault C, Weilbaecher K, Eltoum I, Siegal G, et al. Comparison of five antibodies as markers in the diagnosis of melanoma in cytologic preparations. Am J Clin Pathol. 2002;118:930-6 pubmed
	Boi S, Cristofolini P, Togni R, Girlando S, Camerani M, Donner D, et al. Detection of nodal micrometastases using immunohistochemistry and PCR in melanoma of the arm and trunk. Melanoma Res. 2002;12:147-53 pubmed

product information

Product Type :

Antibody

Product Name :

Tyrosinase Monoclonal Antibody (T311)

Catalog # :

MA5-14177

Quantity :

500 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:25-1:100

Species :

Human, Mouse

Clone :

T311

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.

Immunogen :

Recombinant tyrosinase protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:250, Immunohistochemistry (Paraffin): 1:50-1:100, Western Blot: 1:25-1:100

Aliases :

albino; albino locus protein; ATN; C; CMM8; LB24-AB; monophenol monooxygenase; Oca1; OCA1A; OCAIA; oculocutaneous albinism IA; SHEP3; SK29-AB; skc35; Tumor rejection antigen AB; TYR; Tyrosinase; tyrosinase (oculocutaneous albinism IA); tyrosinase precursor

more info or order :

Invitrogen product webpage