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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD171 Monoclonal Antibody (UJ127)
catalog :
MA5-14140
quantity :
500 uL
price :
US 520.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
UJ127
reactivity :
hamsters, human, mouse, pigs
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 22
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:200; loading ...; fig s2c
Shiwaku H, Katayama S, Kondo K, Nakano Y, Tanaka H, Yoshioka Y, et al. Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in mice. Cell Rep Med. 2022;3:100597 pubmed publisher
  • immunohistochemistry; human; 1:100
Geels Y, van der Putten L, van Tilborg A, Lurkin I, Zwarthoff E, Pijnenborg J, et al. Immunohistochemical and genetic profiles of endometrioid endometrial carcinoma arising from atrophic endometrium. Gynecol Oncol. 2015;137:245-51 pubmed publisher
  • immunohistochemistry; human; 1:40; fig 1
  • ELISA; human; 1 ug/ml
  • immunohistochemistry; mouse; 1:40; fig 8
Sung S, Wu I, Chuang P, Petros J, Wu H, Zeng H, et al. Targeting L1 cell adhesion molecule expression using liposome-encapsulated siRNA suppresses prostate cancer bone metastasis and growth. Oncotarget. 2014;5:9911-29 pubmed
  • immunohistochemistry; pigs ; 1:1000
Choi H, Lee Y, Lee Y, Park J, Min K, Park H. Inflammatory responses in the muscle coat of stomach and small bowel in the postoperative ileus model of guinea pig. Yonsei Med J. 2013;54:1336-41 pubmed publisher
  • immunohistochemistry; human; 1:50
Blessmann M, Gröbe A, Quaas A, Kaifi J, Mistakidis G, Bernreuther C, et al. Adhesion molecule L1 is down-regulated in malignant peripheral nerve sheath tumors versus benign neurofibromatosis type 1-associated tumors. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:239-44 pubmed publisher
  • immunocytochemistry; human
  • immunohistochemistry; human
Reinisch C, Tschachler E. The dimensions and characteristics of the subepidermal nerve plexus in human skin--terminal Schwann cells constitute a substantial cell population within the superficial dermis. J Dermatol Sci. 2012;65:162-9 pubmed publisher
  • flow cytometry; human
Dou X, Menkari C, Shanmugasundararaj S, Miller K, Charness M. Two alcohol binding residues interact across a domain interface of the L1 neural cell adhesion molecule and regulate cell adhesion. J Biol Chem. 2011;286:16131-9 pubmed publisher
  • immunohistochemistry; human; 1:150
Rawnaq T, Quaas A, Zander H, Gros S, Reichelt U, Blessmann M, et al. L1 is highly expressed in tumors of the nervous system: a study of over 8000 human tissues. J Surg Res. 2012;173:314-9 pubmed publisher
  • flow cytometry; human
  • immunoprecipitation; human
  • immunohistochemistry; human
Chen M, Lee C, Leland H, Silletti S. Modification of the L1-CAM carboxy-terminus in pancreatic adenocarcinoma cells. Tumour Biol. 2011;32:347-57 pubmed publisher
  • immunohistochemistry; human
Novelli M, Rossi S, Rodriguez Justo M, Taniere P, Seddon B, Toffolatti L, et al. DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology. 2010;57:259-70 pubmed publisher
  • immunoprecipitation; hamsters
  • immunohistochemistry; human
Chen M, Lee C, Leland H, Lin G, Montgomery A, Silletti S. Inside-out regulation of L1 conformation, integrin binding, proteolysis, and concomitant cell migration. Mol Biol Cell. 2010;21:1671-85 pubmed publisher
  • western blot; human
Son M, Woolard K, Nam D, Lee J, Fine H. SSEA-1 is an enrichment marker for tumor-initiating cells in human glioblastoma. Cell Stem Cell. 2009;4:440-52 pubmed publisher
  • immunohistochemistry; human; 1:50
Rawnaq T, Kleinhans H, Uto M, Schurr P, Reichelt U, Cataldegirmen G, et al. Subset of esophageal adenocarcinoma expresses adhesion molecule l1 in contrast to squamous cell carcinoma. Anticancer Res. 2009;29:1195-9 pubmed
  • immunohistochemistry; human; 1:50
Wachowiak R, Fiegel H, Kaifi J, Quaas A, Krickhahn A, Schurr P, et al. L1 is associated with favorable outcome in neuroblastomas in contrast to adult tumors. Ann Surg Oncol. 2007;14:3575-80 pubmed
  • immunohistochemistry; human; 1:150
Kaifi J, Reichelt U, Quaas A, Schurr P, Wachowiak R, Yekebas E, et al. L1 is associated with micrometastatic spread and poor outcome in colorectal cancer. Mod Pathol. 2007;20:1183-90 pubmed
  • immunohistochemistry; human; 1:50
Kaifi J, Strelow A, Schurr P, Reichelt U, Yekebas E, Wachowiak R, et al. L1 (CD171) is highly expressed in gastrointestinal stromal tumors. Mod Pathol. 2006;19:399-406 pubmed
  • western blot; mouse; fig 1
Silletti S, Yebra M, Perez B, Cirulli V, McMahon M, Montgomery A. Extracellular signal-regulated kinase (ERK)-dependent gene expression contributes to L1 cell adhesion molecule-dependent motility and invasion. J Biol Chem. 2004;279:28880-8 pubmed
Ivanova I, Arulanantham S, Barr K, Cepeda M, Parkins K, Hamilton A, et al. Targeting FER Kinase Inhibits Melanoma Growth and Metastasis. Cancers (Basel). 2019;11: pubmed publisher
Freeman T, Sayedyahossein S, Johnston D, Sanchez Pupo R, O Donnell B, Huang K, et al. Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells. Cancers (Basel). 2019;11: pubmed publisher
Fukushima N, Sato N, Prasad N, Leach S, Hruban R, Goggins M. Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene. 2004;23:9042-51 pubmed
Gelman M, Ye X, Stull R, Suhy D, Jin L, Ng D, et al. Identification of cell surface and secreted proteins essential for tumor cell survival using a genetic suppressor element screen. Oncogene. 2004;23:8158-70 pubmed
Oliva A, James C, Kingman C, Craighead H, Banker G. Patterning axonal guidance molecules using a novel strategy for microcontact printing. Neurochem Res. 2003;28:1639-48 pubmed
product information
Product Type :
Antibody
Product Name :
CD171 Monoclonal Antibody (UJ127)
Catalog # :
MA5-14140
Quantity :
500 uL
Price :
US 520.00
Clonality :
Monoclonal
Purity :
Protein A/G
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Immunocytochemistry: 1:200, Immunohistochemistry (Frozen): 1:1,000, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 ug/mg protein lysate, Western Blot: 1-2 ug/mL
Species :
Human, Mouse
Clone :
UJ127
Isotype :
IgG1, kappa
Storage :
4 C
Description :
L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
Immunogen :
Homogenous suspension of 16 week human fetal brain
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:200, Immunohistochemistry (Frozen): 1:1,000, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 ug/mg protein lysate, Western Blot: 1-2 ug/mL
Aliases :
antigen identified by monoclonal antibody R1; CAML1; CD 171; CD171; CD171 molecule; HSAS; HSAS1; Hyd; L1; L1 cell adhesion molecule; L1CAM; MASA; MIC5; N-CAM L1; NCAML1; N-CAML1; N-CAM-L1; NCAM-L1; Nerve-growth factor-inducible large external glycoprotein; neural cell adhesion molecule L1; NILE; S10; sCD171; sL1 CAM; sL1CAM; soluble CD 171; soluble CD171; soluble L1 CAM; soluble L1CAM; SPG1
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA