CD171 Monoclonal Antibody (UJ127), Biotin | Invitrogen MA5-14137 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD171 Monoclonal Antibody (UJ127), Biotin

catalog :

MA5-14137

quantity :

500 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

UJ127

reactivity :

hamsters, human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
ELISA; human; 1 ug/ml; fig 1	Sung S, Wu I, Chuang P, Petros J, Wu H, Zeng H, et al. Targeting L1 cell adhesion molecule expression using liposome-encapsulated siRNA suppresses prostate cancer bone metastasis and growth. Oncotarget. 2014;5:9911-29 pubmed
immunohistochemistry; human; 1:50	Blessmann M, Gröbe A, Quaas A, Kaifi J, Mistakidis G, Bernreuther C, et al. Adhesion molecule L1 is down-regulated in malignant peripheral nerve sheath tumors versus benign neurofibromatosis type 1-associated tumors. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:239-44 pubmed publisher
immunocytochemistry; human immunohistochemistry; human	Reinisch C, Tschachler E. The dimensions and characteristics of the subepidermal nerve plexus in human skin--terminal Schwann cells constitute a substantial cell population within the superficial dermis. J Dermatol Sci. 2012;65:162-9 pubmed publisher
flow cytometry; human	Dou X, Menkari C, Shanmugasundararaj S, Miller K, Charness M. Two alcohol binding residues interact across a domain interface of the L1 neural cell adhesion molecule and regulate cell adhesion. J Biol Chem. 2011;286:16131-9 pubmed publisher
immunohistochemistry; human; 1:150	Rawnaq T, Quaas A, Zander H, Gros S, Reichelt U, Blessmann M, et al. L1 is highly expressed in tumors of the nervous system: a study of over 8000 human tissues. J Surg Res. 2012;173:314-9 pubmed publisher
flow cytometry; human immunoprecipitation; human immunohistochemistry; human	Chen M, Lee C, Leland H, Silletti S. Modification of the L1-CAM carboxy-terminus in pancreatic adenocarcinoma cells. Tumour Biol. 2011;32:347-57 pubmed publisher
immunohistochemistry; human	Novelli M, Rossi S, Rodriguez Justo M, Taniere P, Seddon B, Toffolatti L, et al. DOG1 and CD117 are the antibodies of choice in the diagnosis of gastrointestinal stromal tumours. Histopathology. 2010;57:259-70 pubmed publisher
immunohistochemistry; human immunoprecipitation; hamsters	Chen M, Lee C, Leland H, Lin G, Montgomery A, Silletti S. Inside-out regulation of L1 conformation, integrin binding, proteolysis, and concomitant cell migration. Mol Biol Cell. 2010;21:1671-85 pubmed publisher
immunohistochemistry; human; 1:50	Rawnaq T, Kleinhans H, Uto M, Schurr P, Reichelt U, Cataldegirmen G, et al. Subset of esophageal adenocarcinoma expresses adhesion molecule l1 in contrast to squamous cell carcinoma. Anticancer Res. 2009;29:1195-9 pubmed
immunohistochemistry; human; 1:50	Wachowiak R, Fiegel H, Kaifi J, Quaas A, Krickhahn A, Schurr P, et al. L1 is associated with favorable outcome in neuroblastomas in contrast to adult tumors. Ann Surg Oncol. 2007;14:3575-80 pubmed
immunohistochemistry; human; 1:150	Kaifi J, Reichelt U, Quaas A, Schurr P, Wachowiak R, Yekebas E, et al. L1 is associated with micrometastatic spread and poor outcome in colorectal cancer. Mod Pathol. 2007;20:1183-90 pubmed
immunohistochemistry; human; 1:50	Kaifi J, Strelow A, Schurr P, Reichelt U, Yekebas E, Wachowiak R, et al. L1 (CD171) is highly expressed in gastrointestinal stromal tumors. Mod Pathol. 2006;19:399-406 pubmed
	Fukushima N, Sato N, Prasad N, Leach S, Hruban R, Goggins M. Characterization of gene expression in mucinous cystic neoplasms of the pancreas using oligonucleotide microarrays. Oncogene. 2004;23:9042-51 pubmed
	Gelman M, Ye X, Stull R, Suhy D, Jin L, Ng D, et al. Identification of cell surface and secreted proteins essential for tumor cell survival using a genetic suppressor element screen. Oncogene. 2004;23:8158-70 pubmed
	Oliva A, James C, Kingman C, Craighead H, Banker G. Patterning axonal guidance molecules using a novel strategy for microcontact printing. Neurochem Res. 2003;28:1639-48 pubmed

product information

Product Type :

Antibody

Product Name :

CD171 Monoclonal Antibody (UJ127), Biotin

Catalog # :

MA5-14137

Quantity :

500 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 ug/mL, Western Blot: 1 ug/mL

Species :

Human

Clone :

UJ127

Isotype :

IgG1, kappa

Storage :

4 C

Description :

L1CAM/CD171 is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.

Immunogen :

Homogenous suspension of 16 week human fetal brain

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2 ug/mL, Western Blot: 1 ug/mL

Aliases :

antigen identified by monoclonal antibody R1; CAML1; CD 171; CD171; CD171 molecule; HSAS; HSAS1; Hyd; L1; L1 cell adhesion molecule; L1CAM; MASA; MIC5; N-CAM L1; NCAML1; N-CAML1; N-CAM-L1; NCAM-L1; Nerve-growth factor-inducible large external glycoprotein; neural cell adhesion molecule L1; NILE; S10; sCD171; sL1 CAM; sL1CAM; soluble CD 171; soluble CD171; soluble L1 CAM; soluble L1CAM; SPG1

more info or order :

Invitrogen product webpage