HPV Type 16 E7 Monoclonal Antibody (TVG701Y) | Invitrogen MA5-14132 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HPV Type 16 E7 Monoclonal Antibody (TVG701Y)

catalog :

MA5-14132

quantity :

500 uL

price :

US 464.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TVG701Y

reactivity :

Human papillomavirus

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; Human papillomavirus; 1:100	Fule T, Máthé M, Suba Z, Csapo Z, Szarvas T, Tátrai P, et al. The presence of human papillomavirus 16 in neural structures and vascular endothelial cells. Virology. 2006;348:289-96 pubmed
immunohistochemistry; Human papillomavirus; 1:100 western blot; Human papillomavirus; 1:500	Xu Q, Wang S, Xi L, Wu S, Chen G, Zhao Y, et al. Effects of human papillomavirus type 16 E7 protein on the growth of cervical carcinoma cells and immuno-escape through the TGF-beta1 signaling pathway. Gynecol Oncol. 2006;101:132-9 pubmed
	Saeed M, Mertens R, Handgretinger R, Efferth T. Identification of fatal outcome in a childhood nasopharyngeal carcinoma patient by protein expression profiling. Int J Oncol. 2018;53:1721-1731 pubmed publisher
	Torng P, Chan W, Lin C, Huang S. Decreased expression of human papillomavirus E2 protein and transforming growth factor-beta1 in human cervical neoplasia as an early marker in carcinogenesis. J Surg Oncol. 2003;84:17-23 pubmed

product information

Product Type :

Antibody

Product Name :

HPV Type 16 E7 Monoclonal Antibody (TVG701Y)

Catalog # :

MA5-14132

Quantity :

500 uL

Price :

US 464.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Virus

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent

Species :

Virus

Clone :

TVG701Y

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

The HPV E7 proteins are small (HPV16 E7 comprising 98 amino acids, 15kDa), zinc binding phosphoproteins which are localised in the nucleus. They are structurally and functionally similar to the E1A protein of subgenus C adenoviruses. The first 16 amino-terminal amino acids of HPV16 E7 contain a region homologous to a segment of the conserved region 1 (CR1) of the E1A protein of subgenus C adenoviruses. The next domain, up to amino acid 37, is homologous to the entire region 2 (CR2) of E1A. Genetic studies have established that these domains are required for cell transformation in vitro, suggesting similarities in the mechanism of transformation by these viruses. The CR2 homology region contains the LXCXE motif (residues 22-26) involved in binding to the tumour suppressor protein pRb.

Immunogen :

Recombinant HPV-16 E7 protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent

Aliases :

HPV 16-E7; HPV16E7; human papillomavirus

more info or order :

Invitrogen product webpage