p73 Monoclonal Antibody (ER-15) | Invitrogen MA5-14117 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

p73 Monoclonal Antibody (ER-15)

catalog :

MA5-14117

quantity :

500 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ER-15

The same clone is also sold as:

Novus Biologicals: NB600-1279

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 26

Reference
Jim xe9 nez S, Moreno N. Analysis of the Expression Pattern of Cajal-Retzius Cell Markers in the Xenopus laevis Forebrain. Brain Behav Evol. 2022;96:263-282 pubmed publisher
Chizhikov V, Iskusnykh I, Steshina E, Fattakhov N, Lindgren A, Shetty A, et al. Early dorsomedial tissue interactions regulate gyrification of distal neocortex. Nat Commun. 2019;10:5192 pubmed publisher
Funato K, Hayashi T, Echizen K, Negishi L, Shimizu N, Koyama Nasu R, et al. SIRT2-mediated inactivation of p73 is required for glioblastoma tumorigenicity. EMBO Rep. 2018;19: pubmed publisher
Liu J, Zhang C, Wang X, Ly P, Belyi V, Xu Monette Z, et al. E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. Cell Death Differ. 2014;21:1792-804 pubmed publisher
Rodhe J, Kavanagh E, Joseph B. TAp73?-mediated suppression of cell migration requires p57Kip2 control of actin cytoskeleton dynamics. Oncotarget. 2013;4:289-97 pubmed
Romano D, Maccario H, Doherty C, Quinn N, Kolch W, Matallanas D. The differential effects of wild-type and mutated K-Ras on MST2 signaling are determined by K-Ras activation kinetics. Mol Cell Biol. 2013;33:1859-68 pubmed publisher
Accardi R, Scalise M, Gheit T, Hussain I, Yue J, Carreira C, et al. IkappaB kinase beta promotes cell survival by antagonizing p53 functions through DeltaNp73alpha phosphorylation and stabilization. Mol Cell Biol. 2011;31:2210-26 pubmed publisher
Wilhelm M, Rufini A, Wetzel M, Tsuchihara K, Inoue S, Tomasini R, et al. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev. 2010;24:549-60 pubmed publisher
Lapi E, Di Agostino S, Donzelli S, Gal H, Domany E, Rechavi G, et al. PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop. Mol Cell. 2008;32:803-14 pubmed publisher
Heyne K, Schmitt K, Mueller D, Armbruester V, Mestres P, Roemer K. Resistance of mitochondrial p53 to dominant inhibition. Mol Cancer. 2008;7:54 pubmed publisher
Inoue T, Ogawa M, Mikoshiba K, Aruga J. Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly. J Neurosci. 2008;28:4712-25 pubmed publisher
Sudhakar C, Jain N, Swarup G. Sp1-like sequences mediate human caspase-3 promoter activation by p73 and cisplatin. FEBS J. 2008;275:2200-13 pubmed publisher
Zitterbart K, Zavrelova I, Kadlecova J, Spesna R, Kratochvilova A, Pavelka Z, et al. p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival. Acta Neuropathol. 2007;114:641-50 pubmed
Lee J, Basak J, Demehri S, Kopan R. Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes. Development. 2007;134:2795-806 pubmed
Toscano F, Parmentier B, Fajoui Z, Estornes Y, Chayvialle J, Saurin J, et al. p53 dependent and independent sensitivity to oxaliplatin of colon cancer cells. Biochem Pharmacol. 2007;74:392-406 pubmed
Limesand K, Schwertfeger K, Anderson S. MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Mol Cell Biol. 2006;26:8840-56 pubmed
Lapi E, Iovino A, Fontemaggi G, Soliera A, Iacovelli S, Sacchi A, et al. S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation. Oncogene. 2006;25:3628-37 pubmed
Yoshida M, Assimacopoulos S, Jones K, Grove E. Massive loss of Cajal-Retzius cells does not disrupt neocortical layer order. Development. 2006;133:537-45 pubmed
Jiang Y, Lo W, Akhmametyeva E, Chang L. Over-expression of p73beta results in apoptotic death of post-mitotic hNT neurons. J Neurol Sci. 2006;240:1-6 pubmed
Sayan A, Paradisi A, Vojtesek B, Knight R, Melino G, Candi E. New antibodies recognizing p73: comparison with commercial antibodies. Biochem Biophys Res Commun. 2005;330:186-93 pubmed
Meyer G, Cabrera Socorro A, Perez Garcia C, Martinez Millan L, Walker N, Caput D. Developmental roles of p73 in Cajal-Retzius cells and cortical patterning. J Neurosci. 2004;24:9878-87 pubmed
Bergamaschi D, Samuels Y, Jin B, Duraisingham S, Crook T, Lu X. ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol. 2004;24:1341-50 pubmed
Frasca F, Vella V, Aloisi A, Mandarino A, Mazzon E, Vigneri R, et al. p73 tumor-suppressor activity is impaired in human thyroid cancer. Cancer Res. 2003;63:5829-37 pubmed
Guan M, Peng H, Yu B, Lu Y. p73 Overexpression and angiogenesis in human colorectal carcinoma. Jpn J Clin Oncol. 2003;33:215-20 pubmed
Vella V, Zhu J, Frasca F, Li C, Vigneri P, Vigneri R, et al. Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function. J Biol Chem. 2003;278:25151-7 pubmed
Kim E, Park J, Um S. Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo. J Biol Chem. 2002;277:32020-8 pubmed publisher

product information

Product Type :

Antibody

Product Name :

p73 Monoclonal Antibody (ER-15)

Catalog # :

MA5-14117

Quantity :

500 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

Immunocytochemistry: 2 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 ug/mL

Species :

Human, Non-human primate

Clone :

ER-15

Isotype :

IgG1, kappa

Storage :

4 C

Description :

P73 (TP73) participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

Immunogen :

Purified monkey recombinant p73alpha protein (aa380-637)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 ug/mL, Immunoprecipitation: Assay-dependent, Western Blot: 1-3 ug/mL

Aliases :

deltaNp73; OTTHUMP00000003479; OTTHUMP00000003480; p53-like transcription factor; p53-related protein; P73; RP23-254N4.10; TAp73; Tp73; transformation related protein 73; Trp73; Tumor protein p73