Placental Alkaline Phosphatase Monoclonal Antibody (8A9) | Invitrogen MA5-14064 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Placental Alkaline Phosphatase Monoclonal Antibody (8A9)

catalog :

MA5-14064

quantity :

500 µL

price :

US 436

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

8A9

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:2	Lee S, Koh Y, Roh H, Cha H, Kwon Y. Ovarian microcystic stromal tumor: A novel extracolonic tumor in familial adenomatous polyposis. Genes Chromosomes Cancer. 2015;54:353-60 pubmed publisher
immunohistochemistry; human; 1:25	Som A, Zhu R, Guo C, Efstathiou E, Xiao L, Pisters L, et al. Recurrent seminomas: clinical features and biologic implications. Urol Oncol. 2012;30:494-501 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Placental Alkaline Phosphatase Monoclonal Antibody (8A9)

Catalog # :

MA5-14064

Quantity :

500 µL

Price :

US 436

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:40-1:80

Species :

Human

Clone :

8A9

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Placental Alkaline Phosphatase plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney for this form of alkaline phosphatase have been well characterized. Placental Alkaline Phosphatase reacts with a membrane-bound isoenzyme (Regan and Nagao type) of Placental Alkaline Phosphatase (PLAP) occurring in the placenta during the 3rd trimester of gestation. Placental Alkaline Phosphatase is useful in the identification of testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA). A proposed function of Placental Alkaline Phosphatase is matrix mineralization; however, mice that lack a functional form of this enzyme show normal skeletal development. Placental Alkaline Phosphatase has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of hypophosphatasia can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.

Immunogen :

Purified human Placental Alkaline Phosphatase (PLAP)

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:40-1:80

Aliases :

Alkaline phosphatase Regan isozyme; alkaline phosphatase, placental; alkaline phosphatase, placental type; alkaline phosphomonoesterase; ALP; ALPP; AP-TNAP; DOA1; FLJ11281; FLJ40094; FLJ61142; FLJ93059; glycerophosphatase; HOPS; MGC161443; MGC167935; P PLAP; PALP; PLA2P; PLAA; Placental alkaline phosphatase 1; PLAP; PLAP-1; Regan isozyme; TNAP; TNSALP