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company name :
Invitrogen
other brands :
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product type :
antibody
product name :
CD10 Monoclonal Antibody (56C6)
catalog :
MA5-14050
quantity :
500 uL
price :
US 524.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
56C6
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 70
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:10; fig 3a
Leo F, Bartels S, Mägel L, Framke T, Büsche G, Jonigk D, et al. Prognostic factors in the myoepithelial-like spindle cell type of metaplastic breast cancer. Virchows Arch. 2016;469:191-201 pubmed publisher
  • immunohistochemistry; human; 1:50; tbl 1
Kim Y, Lee S, Kim J, Sung I, Park H, Shim C, et al. Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms. Gut Liver. 2016;10:220-7 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:20; fig s5
Gascard P, Bilenky M, Sigaroudinia M, Zhao J, Li L, Carles A, et al. Epigenetic and transcriptional determinants of the human breast. Nat Commun. 2015;6:6351 pubmed publisher
  • immunohistochemistry; human; 1:200
Song M, Chung J, Lee G, Cho S, Hong J, Shin D, et al. Statin use has negative clinical impact on non-germinal center in patients with diffuse large B cell lymphoma in rituximab era. Leuk Res. 2015;39:211-5 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
Song M, Chung J, Lee J, Yang D, Kim I, Shin D, et al. High Ki-67 expression in involved bone marrow predicts worse clinical outcome in diffuse large B cell lymphoma patients treated with R-CHOP therapy. Int J Hematol. 2015;101:140-7 pubmed publisher
  • immunohistochemistry; human
Kraan W, Horlings H, Van Keimpema M, Schilder Tol E, Oud M, Scheepstra C, et al. High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites. Blood Cancer J. 2013;3:e139 pubmed publisher
  • immunohistochemistry; human; 1:50
Park H, Lee S, Hong S, Kim J, Sung I, Park H, et al. Early Gastric Cancer-Like Advanced Gastric Cancer versus Advanced Gastric Cancer-Like Early Gastric Cancer. Clin Endosc. 2013;46:155-60 pubmed publisher
  • immunohistochemistry; human; 1:30
Ho M, Quek S, True L, Morrissey C, Corey E, Vessella R, et al. Prostate cancer cell phenotypes based on AGR2 and CD10 expression. Mod Pathol. 2013;26:849-59 pubmed publisher
  • immunohistochemistry; human
Hasby E, Saad H. Immunohistochemical expression of Fas ligand (FasL) and neprilysin (neutral endopeptidase/CD10) in keratoconus. Int Ophthalmol. 2013;33:125-31 pubmed publisher
  • immunohistochemistry; human; 1:10
Romeo S, Bovee J, Kroon H, Tirabosco R, Natali C, Zanatta L, et al. Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. Virchows Arch. 2012;461:561-70 pubmed publisher
  • immunohistochemistry; human; 1:50
Lee H, Lee S, Yoon H, Hong S, Kim J, Sung I, et al. Change of mucosal color in early gastric cancer. J Dig Dis. 2012;13:510-6 pubmed publisher
  • immunohistochemistry; human; 1:50
Yin W, Li J, Chan J. Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review. Diagn Pathol. 2012;7:39 pubmed publisher
  • immunohistochemistry; human; 1:20
Deniz K, Coban G, Okten T. Anti-CD10 (56C6) expression in soft tissue sarcomas. Pathol Res Pract. 2012;208:281-5 pubmed publisher
  • immunohistochemistry; human
Yigit S, Pehlivan F, Evcim G, Etit D. Clinicopathologic features of the mixed epithelial and mesenchymal type metaplastic breast carcinoma with myoepithelial differentiation in a subset of six cases. Pathol Res Pract. 2012;208:147-50 pubmed publisher
  • immunohistochemistry; human; 1:30
Cardinalli I, de Oliveira Filho A, Mastellaro M, Ribeiro R, Aguiar S. A unique case of synchronous functional adrenocortical adenoma and myelolipoma within the ectopic adrenal cortex in a child with Beckwith-Wiedemann syndrome. Pathol Res Pract. 2012;208:189-94 pubmed publisher
  • immunohistochemistry; human; 1:20
Castillo J, Beltran B, Song M, Ilic I, Leppa S, Nurmi H, et al. The Hans algorithm is not prognostic in patients with diffuse large B-cell lymphoma treated with R-CHOP. Leuk Res. 2012;36:413-7 pubmed publisher
  • immunohistochemistry; human; 1:100
Yu G, Kong L, Qu G, Zhang Q, Wang W, Jiang L. Composite lymphoma in the anterior mediastinum: a case report and review of the literature. Diagn Pathol. 2011;6:60 pubmed publisher
  • immunohistochemistry; human; 1:50
Demirkesen C, Tuzuner N, Esen T, Lebe B, Ozkal S. The expression of IgM is helpful in the differentiation of primary cutaneous diffuse large B cell lymphoma and follicle center lymphoma. Leuk Res. 2011;35:1269-72 pubmed publisher
  • immunohistochemistry; human
Masloub S, Abdel Azim A, Elhamid E. CD10 and osteopontin expression in dentigerous cyst and ameloblastoma. Diagn Pathol. 2011;6:44 pubmed publisher
  • immunohistochemistry; human; 1:20
Clay M, Gibson P, Lowell J, Cooper K. Microscopic uterine lymphangioleiomyomatosis perivascular epithelioid cell neoplasm: a case report with the earliest manifestation of this enigmatic neoplasm. Int J Gynecol Pathol. 2011;30:71-5 pubmed publisher
  • immunohistochemistry; human; 1:100
Yu G, Qu G, Kong L, Pan X, Wang W, Lv J. Primary myoepithelial carcinoma of the larynx: case report and review of the literature. Pathol Res Pract. 2011;207:127-30 pubmed publisher
  • immunohistochemistry; human
Mansoor A, Pittaluga S, Beck P, Wilson W, Ferry J, Jaffe E. NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case series. Blood. 2011;117:1447-52 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:10; fig 1, 2, 3
  • immunohistochemistry; human; 1:10
Cheuk W, Tam F, Chan A, Luk I, Yuen A, Chan W, et al. Idiopathic cervical fibrosis--a new member of IgG4-related sclerosing diseases: report of 4 cases, 1 complicated by composite lymphoma. Am J Surg Pathol. 2010;34:1678-85 pubmed publisher
  • immunohistochemistry; human
Pozdzik A, Berton A, Schmeiser H, Missoum W, Decaestecker C, Salmon I, et al. Aristolochic acid nephropathy revisited: a place for innate and adaptive immunity?. Histopathology. 2010;56:449-63 pubmed publisher
  • immunohistochemistry; human; 1:200
Song M, Chung J, Sung Yong O, Lee G, Kim S, Seol Y, et al. Clinical impact of bulky mass in the patient with primary extranodal diffuse large B cell lymphoma treated with R-CHOP therapy. Ann Hematol. 2010;89:985-91 pubmed publisher
  • immunohistochemistry; human; 1:200
Song M, Chung J, Seol Y, Kim S, Shin H, Choi Y, et al. Influence of low absolute lymphocyte count of patients with nongerminal center type diffuse large B-cell lymphoma with R-CHOP therapy. Ann Oncol. 2010;21:140-4 pubmed publisher
  • immunohistochemistry; human; 1:60
Chang I, Huang H, Sung M. Melanotic Xp11 translocation renal cancer: a case with PSF-TFE3 gene fusion and up-regulation of melanogenetic transcripts. Am J Surg Pathol. 2009;33:1894-901 pubmed publisher
  • immunohistochemistry; human; 1:50
Neves C, Soares A, Costa A, de Araujo V, Furuse C, Juliano P, et al. CD10 (Neutral Endopeptidase) Expression in Myoepithelial Cells of Salivary Neoplasms. Appl Immunohistochem Mol Morphol. 2010;18:172-8 pubmed publisher
  • immunohistochemistry; human; 1:10
Cheuk W, Lee K, Chong L, Yuen S, Chan J. IgG4-related Sclerosing disease: a potential new etiology of cutaneous pseudolymphoma. Am J Surg Pathol. 2009;33:1713-9 pubmed publisher
  • immunohistochemistry; human
Dunphy C, O Malley D, Cheng L, Fodrie T, Perkins S, Kaiser Rogers K. Primary mediastinal B-cell lymphoma: detection of BCL2 gene rearrangements by PCR analysis and FISH. J Hematop. 2008;1:77-84 pubmed publisher
  • immunohistochemistry; human
Rys J, Karolewski K, Pudełek J, Kruczak A, Wasilewska A, Vogelgesang M, et al. Perivascular epithelioid tumor (PEComa) of the falciform/ broad ligament. Pol J Pathol. 2008;59:211-5 pubmed
  • immunohistochemistry; human; 1:40
Alacacioglu I, Ozcan M, Ozkal S, Piskin O, Turgut N, Demirkan F, et al. Prognostic significance of immunohistochemical classification of diffuse large B-cell lymphoma. Hematology. 2009;14:84-9 pubmed publisher
  • immunohistochemistry; human; 1:50
Gao H, Ho J, Lee H, Yu C. The presence of Merkel cells and CD10- and CD34-positive stromal cells compared in benign and malignant oral tumors. Oral Dis. 2009;15:259-64 pubmed publisher
  • immunocytochemistry; human; 1:200
  • western blot; human; 1:100
Wang R, Wang S, Malter J, Wang D. Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cells. J Neurochem. 2009;108:1072-82 pubmed publisher
  • immunohistochemistry; human; 1:50
Han H, Lee S, Lee K, Hong S, Kim J, Sung I, et al. Unclassified mucin phenotype of gastric adenocarcinoma exhibits the highest invasiveness. J Gastroenterol Hepatol. 2009;24:658-66 pubmed publisher
  • immunohistochemistry; human; 1:60
Kelten C, Kabukcu S, Sen N, Teke Z, Yaren A, Erdem E, et al. Secondary involvement of the breast in T-cell non-Hodgkin lymphoma, an unusual example mimicking inflammatory breast carcinoma. Arch Gynecol Obstet. 2009;280:149-52 pubmed publisher
  • immunohistochemistry; human
Yegen G, Demir M, Ertan Y, Nalbant O, Tuncyurek M. Can CD10 be used as a diagnostic marker in thyroid pathology?. Virchows Arch. 2009;454:101-5 pubmed publisher
  • immunohistochemistry; human; 1:20
Barisella M, Lampis A, Perrone F, Carbone A. Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: case report with molecular analysis. World J Gastroenterol. 2008;14:6575-7 pubmed
  • immunohistochemistry; rat; 1:60
Esendagli G, Yilmaz G, Canpinar H, Gunel Ozcan A, Guc M, Guc D. Coexistence of different tissue tumourigenesis in an N-methyl-N-nitrosourea-induced mammary carcinoma model: a histopathological report in Sprague-Dawley rats. Lab Anim. 2009;43:60-4 pubmed publisher
  • western blot; human; 1:1000
Bukowska A, Lendeckel U, Krohn A, Keilhoff G, Ten Have S, Neumann K, et al. Atrial fibrillation down-regulates renal neutral endopeptidase expression and induces profibrotic pathways in the kidney. Europace. 2008;10:1212-7 pubmed publisher
  • immunohistochemistry; human; 1:30
Chong Y, Shin J, Cho M, Cui Y, Kim H, Park K. Synchronous primary gastric mantle cell lymphoma and early gastric carcinoma: a case report. Pathol Res Pract. 2008;204:407-11 pubmed publisher
  • immunocytochemistry; human; 1:80
Ahuja A, Gupta N, Kalra N, Srinivasan R, Chawla Y, Rajwanshi A. Role of CD10 immunochemistry in differentiating hepatocellular carcinoma from metastatic carcinoma of the liver. Cytopathology. 2008;19:229-35 pubmed
  • immunohistochemistry; human; 1:50
Costache M, Simionescu O, Sajin M, Chefani A. Cutaneous metastases carcinoma. Case report and pathological considerations. Rom J Morphol Embryol. 2007;48:177-80 pubmed
  • immunohistochemistry - paraffin section; human; 1:20
Cheuk W, Chan J, Nuovo G, Chan M, Fok M. Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum (Lingzhi)?. Int J Surg Pathol. 2007;15:180-6 pubmed
  • immunocytochemistry; human; 1:30
Bircan S, Candir O, Kapucuoglu N, Serel T, Ciris M, Karahan N. CD10 expression in urothelial bladder carcinomas: a pilot study. Urol Int. 2006;77:107-13 pubmed
  • immunohistochemistry; mouse
Li S, Chang S, Qi X, Richardson J, Olson E. Requirement of a myocardin-related transcription factor for development of mammary myoepithelial cells. Mol Cell Biol. 2006;26:5797-808 pubmed
  • immunohistochemistry; human; 1:40
Koren J, Mensikova J, Mukensnabl P, Zamecnik M. Mullerianosis of the urinary bladder: report of a case with suggested metaplastic origin. Virchows Arch. 2006;449:268-71 pubmed
  • immunohistochemistry; human; 1:50
de Araujo V, Altemani A, Furuse C, Martins M, de Araujo N. Immunoprofile of reactive salivary myoepithelial cells in intraductal areas of carcinoma ex-pleomorphic adenoma. Oral Oncol. 2006;42:1011-6 pubmed
  • immunohistochemistry; human; 1:50
Butnor K, Nicholson A, Allred D, Zander D, Henderson D, Barrios R, et al. Expression of renal cell carcinoma-associated markers erythropoietin, CD10, and renal cell carcinoma marker in diffuse malignant mesothelioma and metastatic renal cell carcinoma. Arch Pathol Lab Med. 2006;130:823-7 pubmed
  • immunohistochemistry; human; 1:15
Braham H, Trimeche M, Ziadi S, Mestiri S, Mokni M, Amara K, et al. CD10 expression by fusiform stromal cells in nasopharyngeal carcinoma correlates with tumor progression. Virchows Arch. 2006;449:220-4 pubmed
  • immunohistochemistry; human
Zamecnik M, Skrivanek A. Adenoid basal epithelioma of the uterine cervix in 21-year-old patient. Report of a case with histologic and immunohistochemical study. Cesk Patol. 2005;41:157-62 pubmed
  • western blot; mouse
Hass M, Yankner B. A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J Biol Chem. 2005;280:36895-904 pubmed
Choi M, Ryu J, Vu H, Kim D, Youn Y, Park M, et al. Transferrin-Conjugated Melittin-Loaded L-Arginine-Coated Iron Oxide Nanoparticles for Mitigating Beta-Amyloid Pathology of the 5XFAD Mouse Brain. Int J Mol Sci. 2023;24: pubmed publisher
Xu Y, Xu W, Zhang X, Wang D, Zheng X, Liu W, et al. BM-MSCs overexpressing the Numb enhance the therapeutic effect on cholestatic liver fibrosis by inhibiting the ductular reaction. Stem Cell Res Ther. 2023;14:45 pubmed publisher
Leinroth A, Mirando A, Rouse D, Kobayahsi Y, Tata P, Rueckert H, et al. Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations. Cell Rep. 2022;39:110785 pubmed publisher
Priya R, Jain V, Akhtar J, Chauhan G, Sakhuja P, Goyal S, et al. Plasma-derived candidate biomarkers for detection of gallbladder carcinoma. Sci Rep. 2021;11:23554 pubmed publisher
Tsai C, Su Y, Bamodu O, Chen B, Tsai W, Cheng W, et al. High-Grade B-Cell Lymphoma (HGBL) with MYC and BCL2 and/or BCL6 Rearrangements Is Predominantly BCL6-Rearranged and BCL6-Expressing in Taiwan. Cancers (Basel). 2021;13: pubmed publisher
Jobbagy S, Vitturi D, Salvatore S, Pires M, Rowart P, Emlet D, et al. Nrf2 activation protects against lithium-induced nephrogenic diabetes insipidus. JCI Insight. 2020;5: pubmed publisher
Astarci H, Gurbuz G, Sengul D, Hucumenoglu S, Kocer U, Ustun H. Significance of androgen receptor and CD10 expression in cutaneous basal cell carcinoma and trichoepithelioma. Oncol Lett. 2015;10:3466-3470 pubmed
Sauter J, Ambaye A, Mount S. Increased utilization, verification, and clinical implications of immunocytochemistry: Experience in a northern New England hospital. Diagn Cytopathol. 2015;43:688-95 pubmed publisher
Grimaldi A, Tettamanti G, Congiu T, Girardello R, Malagoli D, Falabella P, et al. The main actors involved in parasitization of Heliothis virescens larva. Cell Tissue Res. 2012;350:491-502 pubmed publisher
Reynolds G, Harris H, Jennings A, Hu K, Grove J, Lalor P, et al. Hepatitis C virus receptor expression in normal and diseased liver tissue. Hepatology. 2008;47:418-27 pubmed
Cho N, Kim S, Ha M, Kim H. Simultaneous heterogenotypic renal cell carcinoma: immunohistochemical and karyoptic analysis by comparative genomic hybridization. Urol Int. 2004;72:344-8 pubmed
Aust S, Obrist P, Jaeger W, Klimpfinger M, Tucek G, Wrba F, et al. Subcellular localization of the ABCG2 transporter in normal and malignant human gallbladder epithelium. Lab Invest. 2004;84:1024-36 pubmed
Song J, Aumüller G, Xiao F, Wilhelm B, Albrecht M. Cell specific expression of CD10/neutral endopeptidase 24.11 gene in human prostatic tissue and cells. Prostate. 2004;58:394-405 pubmed
Antmen B, Haytac M, Sasmaz I, Dogan M, Ergin M, Tanyeli A. Granulocytic sarcoma of gingiva: an unusual case with aleukemic presentation. J Periodontol. 2003;74:1514-9 pubmed
Albrecht M, Mittler A, Wilhelm B, Lundwall A, Lilja H, Aumüller G, et al. Expression and immunolocalisation of neutral endopeptidase in prostate cancer. Eur Urol. 2003;44:415-22 pubmed
Popnikolov N, Ayala A, Graves K, Gatalica Z. Benign myoepithelial tumors of the breast have immunophenotypic characteristics similar to metaplastic matrix-producing and spindle cell carcinomas. Am J Clin Pathol. 2003;120:161-7 pubmed
Freedland S, Seligson D, Liu A, Pantuck A, Paik S, Horvath S, et al. Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer. Prostate. 2003;55:71-80 pubmed
Carpenter T, Stenmark K. Hypoxia decreases lung neprilysin expression and increases pulmonary vascular leak. Am J Physiol Lung Cell Mol Physiol. 2001;281:L941-8 pubmed
product information
Product Type :
Antibody
Product Name :
CD10 Monoclonal Antibody (56C6)
Catalog # :
MA5-14050
Quantity :
500 uL
Price :
US 524.00
Clonality :
Monoclonal
Host :
Mouse
Reactivity :
Human, Mouse, Rat
Applications :
Flow Cytometry: 1:2, Immunohistochemistry (Paraffin): 1:30-1:60, Western Blot: 1:20-1:200
Species :
Human, Mouse, Rat
Clone :
56C6
Isotype :
IgG1
Storage :
4 C
Description :
CD10 (Common Acute Lymphocytic Leukemia Antigen, CALLA), is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, immature B cells with in adult bone marrow and on cells from patients with chronic myelocytic leukemia (CML). CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. CD10 is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. Further, CD10 is a 100 kDa type II transmembrane glycoprotein that exists in a single copy of greater than 45 kb. The 5' untranslated region of the CD10 gene is alternatively spliced, resulting in four separate mRNA transcripts and the coding region is not affected by alternative splicing. Diseases associated with CD10 dysfunction include spinocerebellar ataxia 43 and Charcot-Marie tooth Disease.
Immunogen :
Recombinant external domain of CD10 protein
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1:2, Immunohistochemistry (Paraffin): 1:30-1:60, Western Blot: 1:20-1:200
Aliases :
6030454K05Rik; Atriopeptidase; C85356; CALLA; CD10; CMT2T; common acute lymphoblastic leukemia antigen; common acute lymphocytic leukemia antigen; Enkephalinase; EPN; membrane metallo endopeptidase; membrane metalloendopeptidase; membrane metallo-endopeptidase; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase); membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; MME; NEP; neprilysin; neprilysin-390; neprilysin-411; neutral endopeptidase 24.11; SFE; Skin fibroblast elastase
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA