This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Bcl-X Monoclonal Antibody (2H12)
catalog :
MA5-14011
quantity :
500 uL
price :
US 474.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2H12

The same clone is also sold as:
reactivity :
human, mouse, rat, pigs
application :
western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 7
Reference
Lahat G, Tuvin D, Wei C, Wang W, Pollock R, Anaya D, et al. Molecular prognosticators of complex karyotype soft tissue sarcoma outcome: a tissue microarray-based study. Ann Oncol. 2010;21:1112-20 pubmed publisher
Schulze Bergkamen H, Ehrenberg R, Hickmann L, Vick B, Urbanik T, Schimanski C, et al. Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells. World J Gastroenterol. 2008;14:3829-40 pubmed
Shaknovich R, Basso K, Bhagat G, Mansukhani M, Hatzivassiliou G, Murty V, et al. Identification of rare Epstein-Barr virus infected memory B cells and plasma cells in non-monomorphic post-transplant lymphoproliferative disorders and the signature of viral signaling. Haematologica. 2006;91:1313-20 pubmed
Lindenboim L, Schlipf S, Kaufmann T, Borner C, Stein R. Bcl-x(S) induces an NGF-inhibitable cytochrome c release. Exp Cell Res. 2004;297:392-403 pubmed
Wang J, Wei Q, Wang C, Hill W, Hess D, Dong Z. Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria. J Biol Chem. 2004;279:19948-54 pubmed
Sharif M, Whitehouse A, Sharman P, Perry M, Adams M. Increased apoptosis in human osteoarthritic cartilage corresponds to reduced cell density and expression of caspase-3. Arthritis Rheum. 2004;50:507-15 pubmed
Korkolopoulou P, Lazaris A, Konstantinidou A, Kavantzas N, Patsouris E, Christodoulou P, et al. Differential expression of bcl-2 family proteins in bladder carcinomas. Relationship with apoptotic rate and survival. Eur Urol. 2002;41:274-83 pubmed
product information
Product Type :
Antibody
Product Name :
Bcl-X Monoclonal Antibody (2H12)
Catalog # :
MA5-14011
Quantity :
500 uL
Price :
US 474.00
Clonality :
Monoclonal
Purity :
protein A
Host :
Mouse
Reactivity :
Human, Mouse, Porcine, Rat
Applications :
Flow Cytometry: Assay-dependent, Immunohistochemistry (Paraffin): 2-4 ug/mL, Western Blot: Assay-Dependent
Species :
Human, Mouse, Porcine, Rat
Clone :
2H12
Isotype :
IgG2a
Storage :
4 C
Description :
The protein encoded the BCL-X gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.
Immunogen :
A synthetic peptide, aa 3-14 (Cys-QSNRELVVDFLS) of human Bcl-X protein. This amino acid sequence is shared by human and murine bcl-X protein.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-dependent, Immunohistochemistry (Paraffin): 2-4 ug/mL, Western Blot: Assay-Dependent
Aliases :
anti-apoptosis regulatory protein; anti-apoptotic Bcl-2 gene family member; anti-apoptotic Bcl-xL; anti-apoptotic regulator Bcl-xL; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl 2 like 1; bcl x; Bcl xL; BCL XL/S; Bcl(X)L; bcl-2 L1; BCL2 like 1; BCL2L; Bcl2l1; bcl2-L-1; BCL2-like 1; Bcl-2-like protein 1; BCL2-like protein 1; BCLX; bcl-x; Bcl-x long protein; BclxL; Bcl-xL; BCL-XL/S; BclXS; bcl-xS; BLC2L; DKFZp781P2092; PPP1R52; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3; unnamed protein product
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA