Nkx2.1 Monoclonal Antibody (8G7G3/1), Biotin | Invitrogen MA5-13958 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Nkx2.1 Monoclonal Antibody (8G7G3/1), Biotin

catalog :

MA5-13958

quantity :

500 µL

price :

US 446.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

8G7G3/1

reactivity :

zebra finch, human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 48

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human	Ooi H, Chen C, Hsiao Y, Huang W, Hsieh B. Influence of thyroid transcription factor-1 on fluorodeoxyglucose uptake and prognosis of non-small cell lung cancer. Anticancer Res. 2014;34:2467-75 pubmed
immunohistochemistry; human	Mescam Mancini L, Lantuejoul S, Moro Sibilot D, Rouquette I, Souquet P, Audigier Valette C, et al. On the relevance of a testing algorithm for the detection of ROS1-rearranged lung adenocarcinomas. Lung Cancer. 2014;83:168-73 pubmed publisher
immunohistochemistry; human; 1:200	Kawaguchi K, Lu F, Kaplan R, Liu Y, Chadwick P, Chen Z, et al. In search of the ideal immunopanel to distinguish metastatic mammary carcinoma from primary lung carcinoma: a tissue microarray study of 207 cases. Appl Immunohistochem Mol Morphol. 2014;22:266-74 pubmed publisher
immunohistochemistry; human; 1:50	Ferretti G, Busser B, de Fraipont F, Reymond E, McLeer Florin A, Mescam Mancini L, et al. Adequacy of CT-guided biopsies with histomolecular subtyping of pulmonary adenocarcinomas: influence of ATS/ERS/IASLC guidelines. Lung Cancer. 2013;82:69-75 pubmed publisher
immunohistochemistry; human; 1:100	Ishida M, Sekine S, Fukagawa T, Ohashi M, Morita S, Taniguchi H, et al. Neuroendocrine carcinoma of the stomach: morphologic and immunohistochemical characteristics and prognosis. Am J Surg Pathol. 2013;37:949-59 pubmed publisher
immunohistochemistry; human; 1:200	Morita S, Yoshida A, Goto A, Ota S, Tsuta K, Yokozawa K, et al. High-grade lung adenocarcinoma with fetal lung-like morphology: clinicopathologic, immunohistochemical, and molecular analyses of 17 cases. Am J Surg Pathol. 2013;37:924-32 pubmed publisher
immunocytochemistry; human; 1:1000	Hermanns P, Grasberger H, Cohen R, Freiberg C, Dörr H, Refetoff S, et al. Two cases of thyroid dysgenesis caused by different novel PAX8 mutations in the DNA-binding region: in vitro studies reveal different pathogenic mechanisms. Thyroid. 2013;23:791-6 pubmed publisher
immunohistochemistry; human; 1:50	Kahveci R, Gürer B, Kaygusuz G, Sekerci Z. Miliary brain metastases from occult lung adenocarcinoma: Radiologic and histopathologic confirmation. J Neurosci Rural Pract. 2012;3:386-9 pubmed publisher
immunohistochemistry; human; 1:100	Masago K, Hosada W, Sasaki E, Murakami Y, Sugano M, Nagasaka T, et al. Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature. Case Rep Oncol. 2012;5:471-8 pubmed publisher
immunocytochemistry; human; 1:50	Kimbrell H, Gustafson K, Huang M, Ehya H. Subclassification of non-small cell lung cancer by cytologic sampling: a logical approach with selective use of immunocytochemistry. Acta Cytol. 2012;56:419-24 pubmed publisher
immunohistochemistry; human	Roos A, Berg T, Barton J, Didon L, Nord M. Airway epithelial cell differentiation during lung organogenesis requires C/EBP? and C/EBP?. Dev Dyn. 2012;241:911-23 pubmed publisher
immunohistochemistry; rat; 1:50	Toba H, Sakiyama S, Kenzaki K, Kawakami Y, Uyama K, Bando Y, et al. Implantation of fetal rat lung fragments into bleomycin-induced pulmonary fibrosis. J Thorac Cardiovasc Surg. 2012;143:1429-35 pubmed publisher
immunohistochemistry; human; 1:100	Hashimoto K, Sasajima Y, Ando M, Yonemori K, Hirakawa A, Furuta K, et al. Immunohistochemical profile for unknown primary adenocarcinoma. PLoS ONE. 2012;7:e31181 pubmed publisher
western blot; mouse	Tagne J, Gupta S, Gower A, Shen S, Varma S, Lakshminarayanan M, et al. Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors. PLoS ONE. 2012;7:e29907 pubmed publisher
immunohistochemistry; human; 1:200	Ko Y, Hwang T, Han H, Lim S, Kim W, Oh S. Primary pure squamous cell carcinoma of the thyroid: report and histogenic consideration of a case involving a BRAF mutation. Pathol Int. 2012;62:43-8 pubmed publisher
immunohistochemistry; human; 1:200	Rijlaarsdam M, van Herk H, Gillis A, Stoop H, Jenster G, Martens J, et al. Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours. Br J Cancer. 2011;105:854-63 pubmed publisher
immunohistochemistry; human; 1:1000	Pelosi G, Sonzogni A, Galetta D, Perrone F, Braidotti P, Manzotti M, et al. Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type. Virchows Arch. 2011;458:497-503 pubmed publisher
immunohistochemistry; human; 1:50	Mukhopadhyay S, Katzenstein A. Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6. Am J Surg Pathol. 2011;35:15-25 pubmed publisher
immunohistochemistry; human	Rychly B, Kazakov D, Danis D, Szep Z, Michal M. Primary adenomyoepithelioma of the sellar region: a case report. Am J Surg Pathol. 2010;34:1550-4 pubmed publisher
immunohistochemistry; human	La Rosa S, Chiaravalli A, Placidi C, Papanikolaou N, Cerati M, Capella C. TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies. Virchows Arch. 2010;457:497-507 pubmed publisher
immunohistochemistry; human; 1:100	Rajatapiti P, de Rooij J, Beurskens L, Keijzer R, Tibboel D, Rottier R, et al. Effect of oxygen on the expression of hypoxia-inducible factors in human fetal lung explants. Neonatology. 2010;97:346-54 pubmed publisher
immunohistochemistry; human; 1:100	Kuroda N, Hamaguchi N, Inoue K, Ohara M, Mizuno K, Hayashi Y, et al. Application of immunocytochemistry to the diagnosis of primary epithelioid angiosarcoma of the lung. Med Mol Morphol. 2009;42:250-3 pubmed publisher
immunohistochemistry; human; 1:25	Sterlacci W, Fiegl M, Hilbe W, Auberger J, Mikuz G, Tzankov A. Clinical relevance of neuroendocrine differentiation in non-small cell lung cancer assessed by immunohistochemistry: a retrospective study on 405 surgically resected cases. Virchows Arch. 2009;455:125-32 pubmed publisher
immunohistochemistry; mouse	Didon L, Roos A, Elmberger G, Gonzalez F, Nord M. Lung-specific inactivation of CCAAT/enhancer binding protein alpha causes a pathological pattern characteristic of COPD. Eur Respir J. 2010;35:186-97 pubmed publisher
immunohistochemistry; human; 1:20	La Rosa S, Bernasconi B, Micello D, Finzi G, Capella C. Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature. Endocr Pathol. 2009;20:24-34 pubmed publisher
immunohistochemistry; human; 1:50	McDonald J, Pelloski C, Ledoux A, Sun M, Raso G, Komaki R, et al. Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung. Clin Cancer Res. 2008;14:7832-7 pubmed publisher
immunohistochemistry; human; 1:2.000	Ralston J, Chiriboga L, Nonaka D. MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma. Mod Pathol. 2008;21:1357-62 pubmed publisher
immunohistochemistry; human; 1:200	Li C, Goto A, Watanabe A, Murata K, Ota S, Niki T, et al. AKR1B10 in usual interstitial pneumonia: expression in squamous metaplasia in association with smoking and lung cancer. Pathol Res Pract. 2008;204:295-304 pubmed publisher
immunohistochemistry; mouse	De Langhe S, Carraro G, Tefft D, Li C, Xu X, Chai Y, et al. Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling. PLoS ONE. 2008;3:e1516 pubmed publisher
immunohistochemistry; human; 1:50	Kargi A, Gurel D, Tuna B. The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas. Appl Immunohistochem Mol Morphol. 2007;15:415-20 pubmed
immunohistochemistry; human; 1:100	Kuroda N, Oonishi K, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, et al. Invasive micropapillary carcinoma of the colon: an immunohistochemical study. Med Mol Morphol. 2007;40:226-30 pubmed
immunohistochemistry; human	Nonaka D, Tang Y, Chiriboga L, Rivera M, Ghossein R. Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms. Mod Pathol. 2008;21:192-200 pubmed
immunohistochemistry; human; 1:80	Yaren A, Kelten C, Akbulut M, Teke Z, Duzcan E, Erdem E. Primary neuroendocrine carcinoma of the breast: a case report. Tumori. 2007;93:496-8 pubmed
immunohistochemistry; human; 1:100	Gamal G, Sano T, Sakurai S, Kawashima O, Sugano M, Nakajima T. Immunohistopathological re-evaluation of adenocarcinoma of the lung with mixed subtypes using a tissue microarray technique and hierarchical clustering analysis. Pathol Int. 2007;57:765-74 pubmed
immunohistochemistry; mouse	Que J, Okubo T, Goldenring J, Nam K, Kurotani R, Morrisey E, et al. Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development. 2007;134:2521-31 pubmed
western blot; zebra finch; 1:100	Scott B, Lois C. Developmental origin and identity of song system neurons born during vocal learning in songbirds. J Comp Neurol. 2007;502:202-14 pubmed
immunohistochemistry; human; 1:100	Kohri T, Sugano M, Kawashima O, Saito R, Sakurai S, Sano T, et al. Prognostic model of stage II non-small cell lung cancer by a discriminant analysis of the immunohistochemical protein expression. Surg Today. 2006;36:1039-46 pubmed
immunohistochemistry; mouse; 1:100	Moreno Barriuso N, López Malpartida A, de Pablo F, Pichel J. Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos. Dev Dyn. 2006;235:2040-50 pubmed
immunohistochemistry; human; 1:100	Kuroda N, Hamauzu T, Toi M, Yamaoka K, Miyazaki E, Hiroi M, et al. Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report. APMIS. 2005;113:550-4 pubmed
immunohistochemistry; human; 1:50	Kreft A, Hansen T, Kirkpatrick C. Thyroid transcription factor 1 expression in cystic lesions of the neck: an immunohistochemical investigation of thyroglossal duct cysts, branchial cleft cysts and metastatic papillary thyroid cancer. Virchows Arch. 2005;447:9-11 pubmed
immunohistochemistry; human; 1:100	Gao Z, Urbanski S. The spectrum of pulmonary mucinous cystic neoplasia : a clinicopathologic and immunohistochemical study of ten cases and review of literature. Am J Clin Pathol. 2005;124:62-70 pubmed
immunocytochemistry; human; 1:1000	Grasberger H, Ringkananont U, Lefrancois P, Abramowicz M, Vassart G, Refetoff S. Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity. Mol Endocrinol. 2005;19:1779-91 pubmed
	Bakir K, Kocer N, Deniz H, Güldür M. TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma. Ann Diagn Pathol. 2004;8:337-41 pubmed
	Barbareschi M, Roldo C, Zamboni G, Capelli P, Cavazza A, Macri E, et al. CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors. Am J Surg Pathol. 2004;28:1169-76 pubmed
	Barbareschi M, Murer B, Colby T, Chilosi M, Macri E, Loda M, et al. CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs. Am J Surg Pathol. 2003;27:141-9 pubmed
	Di Palma T, Nitsch R, Mascia A, Nitsch L, Di Lauro R, Zannini M. The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription. J Biol Chem. 2003;278:3395-402 pubmed
	Xu R, Murray M, Jagirdar J, Delgado Y, Melamed J. Placental transmogrification of the lung is a histologic pattern frequently associated with pulmonary fibrochondromatous hamartoma. Arch Pathol Lab Med. 2002;126:562-6 pubmed
	Cheuk W, Kwan M, Suster S, Chan J. Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas. Arch Pathol Lab Med. 2001;125:228-31 pubmed

product information

Product Type :

Antibody

Product Name :

Nkx2.1 Monoclonal Antibody (8G7G3/1), Biotin

Catalog # :

MA5-13958

Quantity :

500 µL

Price :

US 446.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1:10

Species :

Human, Mouse, Rat

Clone :

8G7G3/1

Isotype :

IgG1, kappa

Storage :

4° C

Description :

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Immunogen :

Rat TTF-1 recombinant protein

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:10

Aliases :

AV026640; BCH; BHC; homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2; NK2 homeobox 1; NK-2 homolog A; NKX2.1; Nkx-2.1; NKX2-1; NKX2A; NMTC1; RNA polymerase I transcription termination factor; T/EBP; TEBP; Thyroid nuclear factor 1; thyroid transcription factor 1; thyroid transcription factor 1 TTF-1 NK-2; thyroid transcription factor 1-like; thyroid-specific enhancer-binding protein; tinman; TITF1; TTF1; TTF-1

more info or order :

Invitrogen product webpage