VHL Monoclonal Antibody (Ig33) | Invitrogen MA5-13940 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

VHL Monoclonal Antibody (Ig33)

catalog :

MA5-13940

quantity :

500 µL

price :

US 450.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Ig33

reactivity :

human, mouse

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 9

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:200	Lessi F, Mazzanti C, Tomei S, Di Cristofano C, Minervini A, Menicagli M, et al. VHL and HIF-1?: gene variations and prognosis in early-stage clear cell renal cell carcinoma. Med Oncol. 2014;31:840 pubmed publisher
immunohistochemistry; human	Nagi F, Omar A, Mostafa M, Mohammed E, Abd Elwahed Hussein M. The expression pattern of Von Hippel-Lindau tumor suppressor protein, MET proto-oncogene, and TFE3 transcription factor oncoprotein in renal cell carcinoma in Upper Egypt. Ultrastruct Pathol. 2011;35:79-86 pubmed publisher
immunohistochemistry; human	Minervini A, Di Cristofano C, Gacci M, Serni S, Menicagli M, Lanciotti M, et al. Prognostic role of histological necrosis for nonmetastatic clear cell renal cell carcinoma: correlation with pathological features and molecular markers. J Urol. 2008;180:1284-9 pubmed publisher
immunohistochemistry; human; 1:200	Di Cristofano C, Minervini A, Menicagli M, Salinitri G, Bertacca G, Pefanis G, et al. Nuclear expression of hypoxia-inducible factor-1alpha in clear cell renal cell carcinoma is involved in tumor progression. Am J Surg Pathol. 2007;31:1875-81 pubmed
immunohistochemistry; human; 1:200	Lee S, Garner E, Welch W, Berkowitz R, Mok S. Over-expression of hypoxia-inducible factor 1 alpha in ovarian clear cell carcinoma. Gynecol Oncol. 2007;106:311-7 pubmed
	Vranic S, Frkovic Grazio S, Bilalovic N, Gatalica Z. Angiogenesis in triple-negative adenoid cystic carcinomas of the breast. Virchows Arch. 2011;459:377-82 pubmed publisher
	Petrella B, Brinckerhoff C. PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma. Cancer Biol Ther. 2009;8:1389-401 pubmed
	Petrella B, Lohi J, Brinckerhoff C. Identification of membrane type-1 matrix metalloproteinase as a target of hypoxia-inducible factor-2 alpha in von Hippel-Lindau renal cell carcinoma. Oncogene. 2005;24:1043-52 pubmed
	Maruya S, Kim H, Weber R, Lee J, Kies M, Luna M, et al. Gene expression screening of salivary gland neoplasms: molecular markers of potential histogenetic and clinical significance. J Mol Diagn. 2004;6:180-90 pubmed

product information

Product Type :

Antibody

Product Name :

VHL Monoclonal Antibody (Ig33)

Catalog # :

MA5-13940

Quantity :

500 µL

Price :

US 450.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL

Species :

Human, Mouse

Clone :

Ig33

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Immunogen :

A recombinant protein containing aa 1-213 of human VHL

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL

Aliases :

elongin binding protein; HRCA1; Protein G7; pVHL; RCA1; VHL; VHL1; VHL19; Vhlh; VHLp18(MEA); Von Hippel Lindau; von hippel-lindau; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome homolog; von Hippel-Lindau syndrome protein homolog; von Hippel-Lindau tumor suppressor; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase