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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
POLB Monoclonal Antibody (18S)
catalog :
MA5-13899
quantity :
500 uL
price :
US 484.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
18S
reactivity :
Chinese hamsters, human, mouse, rat, bovine, Xenopus laevis
application :
western blot, immunoprecipitation
more info or order :
Invitrogen product webpage
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:5000; fig s1b
Fang Q, Inanç B, Schamus S, Wang X, Wei L, Brown A, et al. HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. Nat Commun. 2014;5:5513 pubmed publisher
  • western blot; mouse
Unnikrishnan A, Raffoul J, Patel H, Prychitko T, Anyangwe N, Meira L, et al. Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice. Free Radic Biol Med. 2009;46:1488-99 pubmed publisher
  • western blot; human; 1:500
Rubio D, Garcia S, Paz M, de la Cueva T, Lopez Fernandez L, Lloyd A, et al. Molecular characterization of spontaneous mesenchymal stem cell transformation. PLoS ONE. 2008;3:e1398 pubmed publisher
  • western blot; human; 1:1000
Hu D, Tang H, Liang H, Tang D, Liu Y, Ji W, et al. Possible role of DNA polymerase beta in protecting human bronchial epithelial cells against cytotoxicity of hydroquinone. Biomed Environ Sci. 2007;20:171-7 pubmed
  • western blot; human
El Andaloussi N, Valovka T, Toueille M, Hassa P, Gehrig P, Covic M, et al. Methylation of DNA polymerase beta by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen. FASEB J. 2007;21:26-34 pubmed
  • western blot; mouse
Valiunas V, Polosina Y, Miller H, Potapova I, Valiuniene L, Doronin S, et al. Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions. J Physiol. 2005;568:459-68 pubmed
  • western blot; human; 1:200
Albertella M, Lau A, O Connor M. The overexpression of specialized DNA polymerases in cancer. DNA Repair (Amst). 2005;4:583-93 pubmed
Bigarella C, Li J, Rimmelé P, Liang R, Sobol R, Ghaffari S. FOXO3 Transcription Factor Is Essential for Protecting Hematopoietic Stem and Progenitor Cells from Oxidative DNA Damage. J Biol Chem. 2017;292:3005-3015 pubmed publisher
Luo H, Chan D, Yang T, Rodriguez M, Chen B, Leng M, et al. A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment. Mol Cell Biol. 2004;24:8356-65 pubmed
Cabelof D, Raffoul J, Nakamura J, Kapoor D, Abdalla H, Heydari A. Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency. J Biol Chem. 2004;279:36504-13 pubmed
Raffoul J, Cabelof D, Nakamura J, Meira L, Friedberg E, Heydari A. Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair. J Biol Chem. 2004;279:18425-33 pubmed
Purschke M, Kasten Pisula U, Brammer I, Dikomey E. Human and rodent cell lines showing no differences in the induction but differing in the repair kinetics of radiation-induced DNA base damage. Int J Radiat Biol. 2004;80:29-38 pubmed
Martinet W, Knaapen M, De Meyer G, Herman A, Kockx M. Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques. Circulation. 2002;106:927-32 pubmed
Park S, Lam W, Cheng Y. X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance. Cancer Res. 2002;62:459-65 pubmed
Martinet W, Knaapen M, De Meyer G, Herman A, Kockx M. Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering. Circ Res. 2001;88:733-9 pubmed
product information
Product Type :
Antibody
Product Name :
POLB Monoclonal Antibody (18S)
Catalog # :
MA5-13899
Quantity :
500 uL
Price :
US 484.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Bovine, Hamster, Human, Mouse, Rat, Xenopus laevis
Applications :
Immunoprecipitation: 2 ug/mL, Western Blot: 1-2 ug/mL
Species :
Bovine, Hamster, Human, Mouse, Rat, Xenopus laevis
Clone :
18S
Isotype :
IgG1
Storage :
4 C
Description :
DNA polymerase beta comprises an amino-terminal 8- kDa domain and a carboxy-terminal 31- kDa domain. The N-terminal ssDNA binding domain has a deoxyribose phosphodiesterase activity while the C-terminal domain has a nucleotidyltransferase activity. Mammalian DNA polymerase beta, a DNA repair polymerase, is constitutively expressed in cultured cells, but treatment of cells with the DNA-alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate up-regulates beta-pol level. DNA polymerase beta fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells.
Immunogen :
Rat DNA polymerase beta protein
Format :
Liquid
Applications w/Dilutions :
Immunoprecipitation: 2 ug/mL, Western Blot: 1-2 ug/mL
Aliases :
A430088C08Rik; DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DNA-directed DNA polymerase beta; hypothetical protein LOC614688; LOW QUALITY PROTEIN: DNA polymerase beta; MGC125976; POL B; Pol beta; POLB; polb.S; polymerase (DNA directed), beta; polymerase (DNA directed), beta S homeolog; polymerase (DNA) beta; polymerase B; polymerase-beta; wu:fa97a05; XELAEV_18020165mg; zgc:109924
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA