POLB Monoclonal Antibody (18S), Biotin | Invitrogen MA5-13896 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

POLB Monoclonal Antibody (18S), Biotin

catalog :

MA5-13896

quantity :

500µL

price :

US 399.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

18S

reactivity :

Chinese hamster, human, mouse, rat, cow, common platanna

application :

western blot, immunoprecipitation

citations: 14

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:200	Calafiore M, Copani A, Deng W. DNA polymerase-? mediates the neurogenic effect of ?-amyloid protein in cultured subventricular zone neurospheres. J Neurosci Res. 2012;90:559-67 pubmed publisher
western blot; mouse	Unnikrishnan A, Raffoul J, Patel H, Prychitko T, Anyangwe N, Meira L, et al. Oxidative stress alters base excision repair pathway and increases apoptotic response in apurinic/apyrimidinic endonuclease 1/redox factor-1 haploinsufficient mice. Free Radic Biol Med. 2009;46:1488-99 pubmed publisher
western blot; human; 1:500	Rubio D, Garcia S, Paz M, de la Cueva T, Lopez Fernandez L, Lloyd A, et al. Molecular characterization of spontaneous mesenchymal stem cell transformation. PLoS ONE. 2008;3:e1398 pubmed publisher
western blot; human; 1:1000	Hu D, Tang H, Liang H, Tang D, Liu Y, Ji W, et al. Possible role of DNA polymerase beta in protecting human bronchial epithelial cells against cytotoxicity of hydroquinone. Biomed Environ Sci. 2007;20:171-7 pubmed
western blot; human	El Andaloussi N, Valovka T, Toueille M, Hassa P, Gehrig P, Covic M, et al. Methylation of DNA polymerase beta by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen. FASEB J. 2007;21:26-34 pubmed
western blot; mouse	Valiunas V, Polosina Y, Miller H, Potapova I, Valiuniene L, Doronin S, et al. Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions. J Physiol. 2005;568:459-68 pubmed
western blot; human; 1:200	Albertella M, Lau A, O Connor M. The overexpression of specialized DNA polymerases in cancer. DNA Repair (Amst). 2005;4:583-93 pubmed
	Luo H, Chan D, Yang T, Rodriguez M, Chen B, Leng M, et al. A new XRCC1-containing complex and its role in cellular survival of methyl methanesulfonate treatment. Mol Cell Biol. 2004;24:8356-65 pubmed
	Cabelof D, Raffoul J, Nakamura J, Kapoor D, Abdalla H, Heydari A. Imbalanced base excision repair in response to folate deficiency is accelerated by polymerase beta haploinsufficiency. J Biol Chem. 2004;279:36504-13 pubmed
	Raffoul J, Cabelof D, Nakamura J, Meira L, Friedberg E, Heydari A. Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair. J Biol Chem. 2004;279:18425-33 pubmed
	Purschke M, Kasten Pisula U, Brammer I, Dikomey E. Human and rodent cell lines showing no differences in the induction but differing in the repair kinetics of radiation-induced DNA base damage. Int J Radiat Biol. 2004;80:29-38 pubmed
	Martinet W, Knaapen M, De Meyer G, Herman A, Kockx M. Elevated levels of oxidative DNA damage and DNA repair enzymes in human atherosclerotic plaques. Circulation. 2002;106:927-32 pubmed
	Park S, Lam W, Cheng Y. X-ray repair cross-complementing gene I protein plays an important role in camptothecin resistance. Cancer Res. 2002;62:459-65 pubmed
	Martinet W, Knaapen M, De Meyer G, Herman A, Kockx M. Oxidative DNA damage and repair in experimental atherosclerosis are reversed by dietary lipid lowering. Circ Res. 2001;88:733-9 pubmed

product information

Product Type :

Antibody

Product Name :

POLB Monoclonal Antibody (18S), Biotin

Catalog # :

MA5-13896

Quantity :

500µL

Price :

US 399.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Hamster, Human, Mouse, Rat, Xenopus laevis

Applications :

Immunoprecipitation: 2 µg/mL, Western Blot: 2 µg/mL

Species :

Bovine, Hamster, Human, Mouse, Rat, Xenopus laevis

Clone :

18S

Isotype :

IgG1

Storage :

4° C

Description :

DNA polymerase beta comprises an amino-terminal 8-kDa domain and a carboxy-terminal 31-kDa domain. The N-terminal ssDNA binding domain has a deoxyribose phosphodiesterase activity while the C-terminal domain has a nucleotidyltransferase activity. Mammalian DNA polymerase beta, a DNA repair polymerase, is constitutively expressed in cultured cells, but treatment of cells with the DNA-alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate up-regulates beta-pol level. DNA polymerase beta fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells.

Immunogen :

Rat DNA polymerase beta protein

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: 2 µg/mL, Western Blot: 2 µg/mL

Aliases :

DNA pol beta, DNA polymerase beta, DNA polymerase beta subunit