XPA Monoclonal Antibody (12F5) | Invitrogen MA5-13835 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

XPA Monoclonal Antibody (12F5)

catalog :

MA5-13835

quantity :

500 µL

price :

US 496.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

12F5

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 14

Reference
Ciminera A, Shuck S, Termini J. Elevated glucose increases genomic instability by inhibiting nucleotide excision repair. Life Sci Alliance. 2021;4: pubmed publisher
Hilton B, Liu J, Cartwright B, Liu Y, Breitman M, Wang Y, et al. Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes. FASEB J. 2017;31:3882-3893 pubmed publisher
Shen J, Fox E, Ahn E, Loeb L. A rapid assay for measuring nucleotide excision repair by oligonucleotide retrieval. Sci Rep. 2014;4:4894 pubmed publisher
Mohni K, Kavanaugh G, Cortez D. ATR pathway inhibition is synthetically lethal in cancer cells with ERCC1 deficiency. Cancer Res. 2014;74:2835-45 pubmed publisher
Dimitrov S, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, et al. Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle. Genes Dev. 2013;27:2274-91 pubmed publisher
Zhu Q, Wani G, Sharma N, Wani A. Lack of CAK complex accumulation at DNA damage sites in XP-B and XP-B/CS fibroblasts reveals differential regulation of CAK anchoring to core TFIIH by XPB and XPD helicases during nucleotide excision repair. DNA Repair (Amst). 2012;11:942-50 pubmed publisher
Muenyi C, States V, Masters J, Fan T, Helm C, States J. Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC). J Ovarian Res. 2011;4:9 pubmed publisher
Arab H, Wani G, Ray A, Shah Z, Zhu Q, Wani A. Dissociation of CAK from core TFIIH reveals a functional link between XP-G/CS and the TFIIH disassembly state. PLoS ONE. 2010;5:e11007 pubmed publisher
Zhu Q, Wani G, Arab H, El Mahdy M, Ray A, Wani A. Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sites. DNA Repair (Amst). 2009;8:262-73 pubmed publisher
Patrick S, Tillison K, Horn J. Recognition of cisplatin-DNA interstrand cross-links by replication protein A. Biochemistry. 2008;47:10188-96 pubmed publisher
Rubio D, Garcia S, Paz M, de la Cueva T, Lopez Fernandez L, Lloyd A, et al. Molecular characterization of spontaneous mesenchymal stem cell transformation. PLoS ONE. 2008;3:e1398 pubmed publisher
Rytkönen A, Hillukkala T, Vaara M, Sokka M, Jokela M, Sormunen R, et al. DNA polymerase epsilon associates with the elongating form of RNA polymerase II and nascent transcripts. FEBS J. 2006;273:5535-49 pubmed
Stevens E, Raffeld M, Espina V, Kristensen G, Trope C, Kohn E, et al. Expression of xeroderma pigmentosum A protein predicts improved outcome in metastatic ovarian carcinoma. Cancer. 2005;103:2313-9 pubmed
Bianco N, Perry G, Smith M, Templeton D, Montano M. Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage. Mol Endocrinol. 2003;17:1344-55 pubmed

product information

Product Type :

Antibody

Product Name :

XPA Monoclonal Antibody (12F5)

Catalog # :

MA5-13835

Quantity :

500 µL

Price :

US 496.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL, Western Blot: 1-2 µg/mL

Species :

Human

Clone :

12F5

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.

Immunogen :

Recombinant human XPA protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): 2-4 µg/mL, Western Blot: 1-2 µg/mL

Aliases :

AI573865; DNA repair protein complementing XP-A cells; DNA repair protein complementing XP-A cells homolog; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; xeroderma pigmentosum group A-complementing protein; Xeroderma pigmentosum group A-complementing protein homolog; xeroderma pigmentosum, complementation group A; XP1; XPA; XPA, DNA damage recognition and repair factor; Xpac