ERCC1 Monoclonal Antibody (3H11) | Invitrogen MA5-13830 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ERCC1 Monoclonal Antibody (3H11)

catalog :

MA5-13830

quantity :

500 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3H11

The same clone is also sold as:

Santa Cruz Biotechnology: sc-53281

reactivity :

human

application :

western blot, immunoprecipitation

citations: 9

Reference
Liu L, Bai Z, Ma X, Wang T, Yang Y, Zhang Z. Effects of taxol resistance gene 1 expression on the chemosensitivity of SGC-7901 cells to oxaliplatin. Exp Ther Med. 2016;11:846-852 pubmed
Watt H, Rachid Z, Jean Claude B. The Concept of Divergent Targeting through the Activation and Inhibition of Receptors as a Novel Chemotherapeutic Strategy: Signaling Responses to Strong DNA-Reactive Combinatorial Mimicries. J Signal Transduct. 2012;2012:282050 pubmed publisher
Tomicic M, Reischmann P, Rasenberger B, Meise R, Kaina B, Christmann M. Delayed c-Fos activation in human cells triggers XPF induction and an adaptive response to UVC-induced DNA damage and cytotoxicity. Cell Mol Life Sci. 2011;68:1785-98 pubmed publisher
Todorova M, Larroque A, Dauphin Pierre S, Fang Y, Jean Claude B. Subcellular distribution of a fluorescence-labeled combi-molecule designed to block epidermal growth factor receptor tyrosine kinase and damage DNA with a green fluorescent species. Mol Cancer Ther. 2010;9:869-82 pubmed publisher
Al Minawi A, Lee Y, Håkansson D, Johansson F, Lundin C, Saleh Gohari N, et al. The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links. Nucleic Acids Res. 2009;37:6400-13 pubmed publisher
Gustavson M, Bourke Martin B, Reilly D, Cregger M, Williams C, Tedeschi G, et al. Development of an unsupervised pixel-based clustering algorithm for compartmentalization of immunohistochemical expression using Automated QUantitative Analysis. Appl Immunohistochem Mol Morphol. 2009;17:329-37 pubmed publisher
Stordal B, Davey R. ERCC1 expression and RAD51B activity correlate with cell cycle response to platinum drug treatment not DNA repair. Cancer Chemother Pharmacol. 2009;63:661-72 pubmed publisher
Guo W, Zhao Y, Jiang Y, Wang R, Hong L, Fan D. ZNRD1 might mediate UV irradiation related DNA damage and repair in human esophageal cancer cells by regulation of ERCC1. Dis Esophagus. 2008;21:730-6 pubmed publisher
Selvakumaran M, Pisarcik D, Bao R, Yeung A, Hamilton T. Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines. Cancer Res. 2003;63:1311-6 pubmed

product information

Product Type :

Antibody

Product Name :

ERCC1 Monoclonal Antibody (3H11)

Catalog # :

MA5-13830

Quantity :

500 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunoprecipitation: 2 ug/mL, Western Blot: 1-3 ug/mL

Species :

Human

Clone :

3H11

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

ERCC1 is a non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. It is responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). It participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. ERCC1 is also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4. (Uniprot)

Immunogen :

Full length recombinant human ERCC1 protein

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: 2 ug/mL, Western Blot: 1-3 ug/mL

Aliases :

COFS4; DNA excision repair protein ERCC-1; ERCC excision repair 1, endonuclease non-catalytic subunit; Ercc1; Ercc-1; excision repair cross-complementation group 1; excision repair cross-complementing 1; excision repair cross-complementing rodent repair deficiency, complementation group 1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); hypothetical protein LOC405807; RAD10; UV20; zgc:77511