IGF1R alpha Monoclonal Antibody (24-60) | Invitrogen MA5-13817 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IGF1R alpha Monoclonal Antibody (24-60)

catalog :

MA5-13817

quantity :

500 µL

price :

US 448.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

24-60

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 3

Reference
Mills J, Osher E, Rieunier G, Mills I, Macaulay V. IGF-1R nuclear import and recruitment to chromatin involves both alpha and beta subunits. Discov Oncol. 2021;12:13 pubmed publisher
Nakamura M, Miyamoto S, Maeda H, Zhang S, Sangai T, Ishii G, et al. Low levels of insulin-like growth factor type 1 receptor expression at cancer cell membrane predict liver metastasis in Dukes' C human colorectal cancers. Clin Cancer Res. 2004;10:8434-41 pubmed
Haimsohn M, Beery R, Karasik A, Kanety H, Geier A. Aurintricarboxylic acid induces a distinct activation of the IGF-I receptor signaling within MDA-231 cells. Endocrinology. 2002;143:837-45 pubmed

product information

Product Type :

Antibody

Product Name :

IGF1R alpha Monoclonal Antibody (24-60)

Catalog # :

MA5-13817

Quantity :

500 µL

Price :

US 448.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:10-1:100, Immunoprecipitation: 2 µg/mL, Inhibition Assays: 1.5 µg/mL, Western Blot: 1:10-1:200

Species :

Human, Mouse

Clone :

24-60

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

IGF1R (Insulin-like Growth Factor1 Receptor) is a receptor tyrosine kinase that mediates actions of insulin-like growth factor 1 (IFG1). It binds IGF1 with high affinity and IGF2/insulin with lower affinity. Activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survial of malignant cells. Ligand binding activates the receptor kinase and leads to receptor autophosphorylation and tyrosines phosphorylation of multiple substrates that function as signaling adapter proteins.

Immunogen :

IGF-1R/3T3 mouse fibroblasts transfected with human type I IGF-receptor cDNA

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:10-1:100, Immunoprecipitation: 2 µg/mL, Inhibition Assays: 1.5 µg/mL, Western Blot: 1:10-1:200

Aliases :

A330103N21Rik; CD221; D930020L01; hyft; IGF-1 receptor; Igf1r; IGF-1R; IGF-I receptor; IGFIR; IGFIRC; IGFR; Igfr1; insulin like growth factor 1 receptor; insulin-like growth factor 1 receptor; Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain; insulin-like growth factor 1 receptor beta subunit; insulin-like growth factor I receptor; insulin-like growth factor receptor 1; insulin-like growth factor-I receptor; insulin-like growth factor-I receptor precursor; JTK13; line 186; soluble IGF1R variant 1; soluble IGF1R variant 2

more info or order :

Invitrogen product webpage