Cdc25A Monoclonal Antibody (DCS-120) | Invitrogen MA5-13794 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cdc25A Monoclonal Antibody (DCS-120)

catalog :

MA5-13794

quantity :

500 µL

price :

US 524

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DCS-120

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig s2	Zhao N, Wang F, Ahmed S, Liu K, Cathcart S, Dimaio D, et al. Androgen Receptor, Although Not a Specific Marker For, Is a Novel Target to Suppress Glioma Stem Cells as a Therapeutic Strategy for Glioblastoma. Front Oncol. 2021;11:616625 pubmed publisher
	Tormo E, Ballester S, Adam Artigues A, Burgues O, Alonso E, Bermejo B, et al. The miRNA-449 family mediates doxorubicin resistance in triple-negative breast cancer by regulating cell cycle factors. Sci Rep. 2019;9:5316 pubmed publisher
	Zhang Y, Lai J, Du Z, Gao J, Yang S, Gorityala S, et al. Targeting radioresistant breast cancer cells by single agent CHK1 inhibitor via enhancing replication stress. Oncotarget. 2016;7:34688-702 pubmed publisher
	Sakurikar N, Thompson R, Montano R, Eastman A. A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase. Oncotarget. 2016;7:1380-94 pubmed publisher
	Brunetto E, Ferrara A, Rampoldi F, Talarico A, Cin E, Grassini G, et al. CDC25A protein stability represents a previously unrecognized target of HER2 signaling in human breast cancer: implication for a potential clinical relevance in trastuzumab treatment. Neoplasia. 2013;15:579-90 pubmed
	Johnson C, Esquela Kerscher A, Stefani G, Byrom M, Kelnar K, Ovcharenko D, et al. The let-7 microRNA represses cell proliferation pathways in human cells. Cancer Res. 2007;67:7713-22 pubmed
	Paternot S, Dumont J, Roger P. Differential utilization of cyclin D1 and cyclin D3 in the distinct mitogenic stimulations by growth factors and TSH of human thyrocytes in primary culture. Mol Endocrinol. 2006;20:3279-92 pubmed
	Jin J, Shirogane T, Xu L, Nalepa G, Qin J, Elledge S, et al. SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase. Genes Dev. 2003;17:3062-74 pubmed

product information

Product Type :

Antibody

Product Name :

Cdc25A Monoclonal Antibody (DCS-120)

Catalog # :

MA5-13794

Quantity :

500 µL

Price :

US 524

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1-2 µg/mL

Species :

Human, Mouse, Rat

Clone :

DCS-120

Isotype :

IgG2a

Storage :

4° C

Description :

CDC25a is a member of the CDC25 family of phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B, and CDC25C. These three genes function at different phases of the cell cycle. CDC25a is required for progression through G1 and S phases of the cell cycle. CDC25a activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.

Immunogen :

Purified recombinant CDC25A

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 µg/mL, Immunohistochemistry (Paraffin): Assay-dependent, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1-2 µg/mL

Aliases :

CDC25 isoform A1-CAG; CDC25A; CDC25A2; CDC25A2-CAG isoform; Cdc25m3; cell division cycle 25A; D9Ertd393e; dual specificity phosphatase Cdc25A; EC 3.1.3.48; M-phase inducer phosphatase 1; MPIP1