INSR beta Monoclonal Antibody (CT-1) | Invitrogen MA5-13778 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

INSR beta Monoclonal Antibody (CT-1)

catalog :

MA5-13778

quantity :

500 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CT-1

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human	Galic S, Hauser C, Kahn B, Haj F, Neel B, Tonks N, et al. Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP. Mol Cell Biol. 2005;25:819-29 pubmed
	Hosawi S, Humphries J, Coward R, Knight D, Humphries M, Lennon R. Global proteomic analysis of insulin receptor interactors in glomerular podocytes. Wellcome Open Res. 2020;5:202 pubmed publisher
	Ohshima M, Kamei S, Fushimi H, Mima S, Yamada T, Yamamoto T. Prediction of Drug Permeability Using In Vitro Blood-Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells. Biores Open Access. 2019;8:200-209 pubmed publisher
	Mitrofanova A, Mallela S, Ducasa G, Yoo T, Rosenfeld Gur E, Zelnik I, et al. SMPDL3b modulates insulin receptor signaling in diabetic kidney disease. Nat Commun. 2019;10:2692 pubmed publisher

product information

Product Type :

Antibody

Product Name :

INSR beta Monoclonal Antibody (CT-1)

Catalog # :

MA5-13778

Quantity :

500 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Affinity Purification: Assay-dependent, ELISA: Assay-dependent, Flow Cytometry: 2 ug/test, Immunocytochemistry: 1:10-1:100, Immunoprecipitation: 2 ug/mL, Western Blot: 1-3 ug/mL

Species :

Human, Mouse, Rat

Clone :

CT-1

Isotype :

IgG1, kappa

Storage :

4 C

Description :

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.

Immunogen :

A 15-mer synthetic peptide corresponding to aa Tyr-KKNGRILTLPRSNPS from the C-terminal of human insulin receptor beta-subunit (aa 1368-1382).

Format :

Liquid

Applications w/Dilutions :

Affinity Purification: Assay-dependent, ELISA: Assay-dependent, Flow Cytometry: 2 ug/test, Immunocytochemistry: 1:10-1:100, Immunoprecipitation: 2 ug/mL, Western Blot: 1-3 ug/mL

Aliases :

4932439J01Rik; CD220; CD220 beta; CD221; D630014A15Rik; HHF5; IGF-I receptor; Insr; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR beta; IR-A; IR-B

more info or order :

Invitrogen product webpage