INSR alpha Monoclonal Antibody (47-9) | Invitrogen MA5-13773 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

INSR alpha Monoclonal Antibody (47-9)

catalog :

MA5-13773

quantity :

500 uL

price :

US 484.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

47-9

reactivity :

human, bovine, pigs , domestic sheep

application :

western blot, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
blocking or activating experiments; human	Romacho T, Azcutia V, Vázquez Bella M, Matesanz N, Cercas E, Nevado J, et al. Extracellular PBEF/NAMPT/visfatin activates pro-inflammatory signalling in human vascular smooth muscle cells through nicotinamide phosphoribosyltransferase activity. Diabetologia. 2009;52:2455-2463 pubmed publisher
blocking or activating experiments; human	Haider D, Schaller G, Kapiotis S, Maier C, Luger A, Wolzt M. The release of the adipocytokine visfatin is regulated by glucose and insulin. Diabetologia. 2006;49:1909-14 pubmed
western blot; human	Goetsch L, Gonzalez A, Leger O, Beck A, Pauwels P, Haeuw J, et al. A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts. Int J Cancer. 2005;113:316-28 pubmed
	Chaudhari A, Gupta R, Patel S, Velingkaar N, Kondratov R. Cryptochromes regulate IGF-1 production and signaling through control of JAK2-dependent STAT5B phosphorylation. Mol Biol Cell. 2017;28:834-842 pubmed publisher
	Kalli K, Falowo O, Bale L, Zschunke M, Roche P, Conover C. Functional insulin receptors on human epithelial ovarian carcinoma cells: implications for IGF-II mitogenic signaling. Endocrinology. 2002;143:3259-67 pubmed
	Sakai K, Lowman H, Clemmons D. Increases in free, unbound insulin-like growth factor I enhance insulin responsiveness in human hepatoma G2 cells in culture. J Biol Chem. 2002;277:13620-7 pubmed

product information

Product Type :

Antibody

Product Name :

INSR alpha Monoclonal Antibody (47-9)

Catalog # :

MA5-13773

Quantity :

500 uL

Price :

US 484.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Human, Ovine, Porcine

Applications :

Inhibition Assays: 10nM

Species :

Bovine, Human, Ovine, Porcine

Clone :

47-9

Isotype :

IgG1

Storage :

4 C

Description :

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.

Immunogen :

IM-9 lymphocytes followed by purified insulin receptor

Format :

Liquid

Applications w/Dilutions :

Inhibition Assays: 10nM

Aliases :

4932439J01Rik; CD220; CD220 beta; D630014A15Rik; DAF-2; HHF5; INSR; insulin receptor; insulin receptor (INSR); insulin receptor precursor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR alpha; IR beta; ir-A; IR-B

more info or order :

Invitrogen product webpage