INSR alpha Monoclonal Antibody (83-7), Biotin | Invitrogen MA5-13764 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

INSR alpha Monoclonal Antibody (83-7), Biotin

catalog :

MA5-13764

quantity :

500 µL

price :

US 454.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

83-7

reactivity :

human, rat, bovine, pigs , domestic sheep, domestic rabbit

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 5

Published Application/Species/Sample/Dilution	Reference
ELISA; human	Umehara A, Nishioka M, Obata T, Ebina Y, Shiota H, Hashida S. A novel ultra-sensitive enzyme immunoassay for soluble human insulin receptor ectodomain and its measurement in urine from healthy subjects and patients with diabetes mellitus. Clin Biochem. 2009;42:1468-75 pubmed publisher
immunocytochemistry; human; 2 ug/ml western blot; human; 1 ug/ml	Bennasroune A, Gardin A, Auzan C, Clauser E, Dirrig Grosch S, Meira M, et al. Inhibition by transmembrane peptides of chimeric insulin receptors. Cell Mol Life Sci. 2005;62:2124-31 pubmed
	Weis F, Menting J, Margetts M, Chan S, Xu Y, Tennagels N, et al. The signalling conformation of the insulin receptor ectodomain. Nat Commun. 2018;9:4420 pubmed publisher
	Meakin P, Mezzapesa A, Benabou E, Haas M, Bonardo B, Grino M, et al. The beta secretase BACE1 regulates the expression of insulin receptor in the liver. Nat Commun. 2018;9:1306 pubmed publisher
	Kalli K, Falowo O, Bale L, Zschunke M, Roche P, Conover C. Functional insulin receptors on human epithelial ovarian carcinoma cells: implications for IGF-II mitogenic signaling. Endocrinology. 2002;143:3259-67 pubmed

product information

Product Type :

Antibody

Product Name :

INSR alpha Monoclonal Antibody (83-7), Biotin

Catalog # :

MA5-13764

Quantity :

500 µL

Price :

US 454.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Human, Ovine, Porcine, Rabbit, Rat

Applications :

ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 2-4 µg/mL

Species :

Bovine, Human, Ovine, Porcine, Rabbit, Rat

Clone :

83-7

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.

Immunogen :

IM-9 lymphocytes followed by IR

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunohistochemistry (Paraffin): 2-4 µg/mL

Aliases :

4932439J01Rik; CD220; CD220 beta; D630014A15Rik; DAF-2; HHF5; INSR; insulin receptor; insulin receptor (INSR); insulin receptor precursor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR alpha; IR beta; ir-A; IR-B