INSR alpha Monoclonal Antibody (83-14), Biotin | Invitrogen MA5-13756 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

INSR alpha Monoclonal Antibody (83-14), Biotin

catalog :

MA5-13756

quantity :

500 uL

price :

US 484.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

83-14

The same clone is also sold as:

Novus Biologicals: NBP2-81038-0.2mg

reactivity :

human

application :

immunocytochemistry, immunoprecipitation

citations: 4

Reference
Fischer Posovszky P, Tornqvist H, Debatin K, Wabitsch M. Inhibition of death-receptor mediated apoptosis in human adipocytes by the insulin-like growth factor I (IGF-I)/IGF-I receptor autocrine circuit. Endocrinology. 2004;145:1849-59 pubmed
Sakai K, Clemmons D. Glucosamine induces resistance to insulin-like growth factor I (IGF-I) and insulin in Hep G2 cell cultures: biological significance of IGF-I/insulin hybrid receptors. Endocrinology. 2003;144:2388-95 pubmed
Hamer I, Foti M, Emkey R, Cordier Bussat M, Philippe J, De Meyts P, et al. An arginine to cysteine(252) mutation in insulin receptors from a patient with severe insulin resistance inhibits receptor internalisation but preserves signalling events. Diabetologia. 2002;45:657-67 pubmed
Sakai K, Lowman H, Clemmons D. Increases in free, unbound insulin-like growth factor I enhance insulin responsiveness in human hepatoma G2 cells in culture. J Biol Chem. 2002;277:13620-7 pubmed

product information

Product Type :

Antibody

Product Name :

INSR alpha Monoclonal Antibody (83-14), Biotin

Catalog # :

MA5-13756

Quantity :

500 uL

Price :

US 484.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunoprecipitation: 2 ug/mL

Species :

Human

Clone :

83-14

Isotype :

IgG2a, kappa

Storage :

4 C

Description :

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.

Immunogen :

IM-9 lymphocytes followed by purified insulin receptor

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:10-1:100, Immunoprecipitation: 2 ug/mL

Aliases :

4932439J01Rik; CD220; CD220 beta; D630014A15Rik; DAF-2; HHF5; INSR; insulin receptor; insulin receptor (INSR); insulin receptor precursor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR alpha; IR beta; ir-A; IR-B