CD137 Monoclonal Antibody (BBK-2), Biotin | Invitrogen MA5-13736 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD137 Monoclonal Antibody (BBK-2), Biotin

catalog :

MA5-13736

quantity :

500 uL

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

BBK-2

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human	Ho W, Pang W, Chong S, Castella A, Al Salam S, Tan T, et al. Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression. Cancer Res. 2013;73:652-61 pubmed publisher
immunohistochemistry; human; 1:30	Anderson M, Zhao S, Freud A, Czerwinski D, Kohrt H, Alizadeh A, et al. CD137 is expressed in follicular dendritic cell tumors and in classical Hodgkin and T-cell lymphomas: diagnostic and therapeutic implications. Am J Pathol. 2012;181:795-803 pubmed publisher
immunohistochemistry; human; 1:15	Alizadeh A, Gentles A, Alencar A, Liu C, Kohrt H, Houot R, et al. Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment. Blood. 2011;118:1350-8 pubmed publisher
flow cytometry; human; 1 ug/ml	Quek B, Lim Y, Lin J, Tan T, Chan J, Biswas A, et al. CD137 enhances monocyte-ICAM-1 interactions in an E-selectin-dependent manner under flow conditions. Mol Immunol. 2010;47:1839-47 pubmed publisher
flow cytometry; human	Baessler T, Charton J, Schmiedel B, Grunebach F, Krusch M, Wacker A, et al. CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells. Blood. 2010;115:3058-69 pubmed publisher
blocking or activating experiments; human; 1:50	Krause C, Klüttermann K, Mauz Körholz C. Molecular mechanisms and gene regulation of melphalan- and hyperthermia-induced apoptosis in Ewing sarcoma cells. Anticancer Res. 2008;28:2585-93 pubmed
immunohistochemistry; human	Jiang D, Yue P, Drenkard D, Schwarz H. Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling. Stem Cells. 2008;26:2372-81 pubmed publisher
	Salih H, Kosowski S, Haluska V, Starling G, Loo D, Lee F, et al. Constitutive expression of functional 4-1BB (CD137) ligand on carcinoma cells. J Immunol. 2000;165:2903-10 pubmed

product information

Product Type :

Antibody

Product Name :

CD137 Monoclonal Antibody (BBK-2), Biotin

Catalog # :

MA5-13736

Quantity :

500 uL

Price :

US 480.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent

Species :

Human

Clone :

BBK-2

Isotype :

IgG1, kappa

Storage :

4 C

Description :

CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.

Immunogen :

Ectodomain of human 4-1BB recombinant protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent

Aliases :

4 1 BB; 41BB; 4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; EGK_00183; homolog of mouse 4-1BB; ILA; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; Ly63; receptor protein 4-1BB; s4 1 BB; s4 1BB; s41BB; sCD137; secreted CD137 antigen; soluble 4 1 BB; soluble 4 1BB; soluble 41BB; soluble CD137; T cell antigen ILA; T-cell antigen 4-1BB; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNF receptor superfamily member 9; TNFRSF9; Tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9

more info or order :

Invitrogen product webpage