Bcl-2 Monoclonal Antibody (8C8) | Invitrogen MA5-13666 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Bcl-2 Monoclonal Antibody (8C8)

catalog :

MA5-13666

quantity :

500µL

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8C8

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 14

Published Application/Species/Dilution	Reference
immunohistochemistry - paraffin section; human; 8 ug/ml; fig 2 western blot; human; 0.2 ug/ml; fig 4	Cookman C, Belcher S. Estrogen Receptor-β Up-Regulates IGF1R Expression and Activity to Inhibit Apoptosis and Increase Growth of Medulloblastoma. Endocrinology. 2015;156:2395-408 pubmed publisher
	Ozer H, Yenicesu G, Arici S, Cetin M, Tuncer E, Cetin A. Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors. Diagn Pathol. 2012;7:124 pubmed publisher
	Ozcura F, Dündar S, Cetin E, Beder N, Dundar M. Effects of estrogen replacement therapy on apoptosis and vascular endothelial growth factor expression in ocular surface epithelial cells: An experimental study. Int J Ophthalmol. 2012;5:64-8 pubmed
	Kundu T, Dey S, Roy M, Siddiqi M, Bhattacharya R. Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin. Cancer Lett. 2005;230:111-21 pubmed
	Abdelzaher E, El-Gendi S, Yehya A, Gowil A. Recurrence of benign meningiomas: predictive value of proliferative index, BCL2, p53, hormonal receptors and HER2 expression. Br J Neurosurg. 2011;25:707-13 pubmed publisher
	Demirkesen C, Tuzuner N, Esen T, Lebe B, Ozkal S. The expression of IgM is helpful in the differentiation of primary cutaneous diffuse large B cell lymphoma and follicle center lymphoma. Leuk Res. 2011;35:1269-72 pubmed publisher
	Elpek G, Küpesiz G, Ogus M. Incidental calcifying fibrous tumor of the stomach presenting as a polyp. Pathol Int. 2006;56:227-31 pubmed
	Aktas S, Kargi A, Olgun N, Diniz G, Erbay A, Vergin C. Prognostic significance of cell proliferation and apoptosis-regulating proteins in Epstein-Barr virus positive and negative pediatric Hodgkin lymphoma. Lymphat Res Biol. 2007;5:175-82 pubmed
	Chakraborty S, Kundu T, Dey S, Bhattacharya R, Siddiqi M, Roy M. Tea-induced apoptosis in human leukemia K562 cells as assessed by comet formation. Asian Pac J Cancer Prev. 2006;7:201-7 pubmed
	Aust S, Pils S, Polterauer S, Horvat R, Cacsire Castillo-Tong D, Pils D, et al. Expression of Bcl-2 and the antiapoptotic BAG family proteins in ovarian cancer. Appl Immunohistochem Mol Morphol. 2013;21:518-24 pubmed publisher
	Mukherjee Nee Chakraborty S, Ghosh U, Bhattacharyya N, Bhattacharya R, Dey S, Roy M. Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol Cell Biochem. 2007;297:31-9 pubmed
	Wildeman M, Gibcus J, Hauptmann M, Begg A, van Velthuysen M, Hoebers F, et al. Radiotherapy in laryngeal carcinoma: can a panel of 13 markers predict response?. Laryngoscope. 2009;119:316-22 pubmed publisher
	Fan C, Lin X, Wang E. Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study. Tumour Biol. 2012;33:1045-52 pubmed
	Ong F, Moonen L, Gallee M, ten Bosch C, Zerp S, Hart A, et al. Prognostic factors in transitional cell cancer of the bladder: an emerging role for Bcl-2 and p53. Radiother Oncol. 2001;61:169-75 pubmed

product information

Product Type :

Antibody

Product Name :

Bcl-2 Monoclonal Antibody (8C8)

Catalog # :

MA5-13666

Quantity :

500µL

Price :

US 309.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

Flow Cytometry: Assay Dependent, Immunofluorescence: 1-2 µg/ml, Immunohistochemistry (Paraffin): 1-2 µg/ml, Western Blot: 1 µg/mL

Species :

Human, Non-human primate

Clone :

8C8

Isotype :

IgG1

Storage :

4° C

Description :

Expression of Bcl-2alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2alpha protein, whereas the normal or hyperplastic germinal centers are negative.

Immunogen :

A Synthetic peptide, aa 41-54 (Cys-GAAPAPGIFSSQPG) of human bcl-2 protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay Dependent, Immunofluorescence: 1-2 µg/ml, Immunohistochemistry (Paraffin): 1-2 µg/ml, Western Blot: 1 µg/mL

Aliases :

bcl-2-like protein 5, bcl-2-related protein A1, bcl2-L-5, hematopoietic BCL2-related protein A1, hemopoietic-specific early response protein, protein BFL-1, BCL-2 alpha isoform

PubMed References :

11690683, 16253767, 16634970, 16839211, 17096185, 18035936, 19160427, 20979437, 21700336, 22302483, 22553757, 22995373, 25885794