Adenovirus Type 2 E1A Monoclonal Antibody (M73) | Invitrogen MA5-13648 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Adenovirus Type 2 E1A Monoclonal Antibody (M73)

catalog :

MA5-13648

quantity :

500 µL

price :

US 436.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

M73

reactivity :

Human mastadenovirus C, Adenoviridae, human

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; Adenoviridae	Sharon D, Schumann M, Macleod S, McPherson R, Chaurasiya S, Shaw A, et al. 2-aminopurine enhances the oncolytic activity of an E1b-deleted adenovirus in hepatocellular carcinoma cells. PLoS ONE. 2013;8:e65222 pubmed publisher
western blot; Adenoviridae; 1:500	Sauthoff H, Pipiya T, Chen S, Heitner S, Cheng J, Huang Y, et al. Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2- and E1b-55kD-mediated degradation of p53. Cancer Gene Ther. 2006;13:686-95 pubmed
immunocytochemistry; Adenoviridae	Saito Y, Sunamura M, Motoi F, Abe H, Egawa S, Duda D, et al. Oncolytic replication-competent adenovirus suppresses tumor angiogenesis through preserved E1A region. Cancer Gene Ther. 2006;13:242-52 pubmed
western blot; human; 1:500	Pipiya T, Sauthoff H, Huang Y, Chang B, Cheng J, Heitner S, et al. Hypoxia reduces adenoviral replication in cancer cells by downregulation of viral protein expression. Gene Ther. 2005;12:911-7 pubmed
	Maemondo M, Saijo Y, Narumi K, Kikuchi T, Usui K, Tazawa R, et al. Gene therapy with secretory leukoprotease inhibitor promoter-controlled replication-competent adenovirus for non-small cell lung cancer. Cancer Res. 2004;64:4611-20 pubmed
	Lang S, McMahon S, Cole M, Hearing P. E2F transcriptional activation requires TRRAP and GCN5 cofactors. J Biol Chem. 2001;276:32627-34 pubmed

image

image 1 :

Formalin-fixed, paraffin-embedded human infected appendix stained with Adenovirus antibody using peroxidase-conjugate and DAB chromogen. Note intense nuclear and cytoplasmic staining of infected epithelial cells.

image 2 :

product information

Product Type :

Antibody

Product Name :

Adenovirus Type 2 E1A Monoclonal Antibody (M73)

Catalog # :

MA5-13648

Quantity :

500 µL

Price :

US 436.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Virus

Applications :

Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1 µg/mL

Species :

Virus

Clone :

M73

Isotype :

IgG2a, kappa

Storage :

4° C

Description :

Adenoviruses are DNA viruses generally widespread in nature that are frequently the cause of acute upper respiratory tract infections (i.e. common colds). 49 human adenovirus serotypes have been discovered and divided into six subgroups, A to E, based on observation. They are an important cause of respiratory illness, conjunctivitis, gastroenteritis, and have more recently been recognized as a potential cause of sexually transmitted diseases. Several types have oncogenic potential though most cause self-limiting febrile illnesses characterized by inflammation of conjunctivae and the respiratory tract. The virus can be isolated from the majority of tonsils/adenoids surgically removed, indicating latent infections. It is not known how long the virus can persist in the body, or whether it is capable of reactivation after long periods. In patients experiencing immunosuppression (e.g. AIDS) it can be reactivated, causing disease. Adenovirus vectors, particularly those based on Ad5, have shown great promise for the development of gene therapy protocols and have been used for clinical purpose.

Immunogen :

Adenovirus

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 1 µg/mL

Aliases :

Adeno Virus; Adeno Virus 2; AdV; AdV-2; HADV; HADV-2

more info or order :

Invitrogen product webpage