Cytokeratin 17 Monoclonal Antibody (E3) | Invitrogen MA5-13539 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cytokeratin 17 Monoclonal Antibody (E3)

catalog :

MA5-13539

quantity :

500 µL

price :

US 436.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 10

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human	Gromova I, Gromov P, Honma N, Kumar S, Rimm D, Talman M, et al. High level PHGDH expression in breast is predominantly associated with keratin 5-positive cell lineage independently of malignancy. Mol Oncol. 2015;9:1636-54 pubmed publisher
immunohistochemistry; mouse	Perez Gomez E, Jerkic M, Prieto M, del Castillo G, Martín Villar E, Letarte M, et al. Impaired wound repair in adult endoglin heterozygous mice associated with lower NO bioavailability. J Invest Dermatol. 2014;134:247-255 pubmed publisher
immunohistochemistry; human	Colmont C, Benketah A, Reed S, Hawk N, Telford W, Ohyama M, et al. CD200-expressing human basal cell carcinoma cells initiate tumor growth. Proc Natl Acad Sci U S A. 2013;110:1434-9 pubmed publisher
immunocytochemistry; human immunohistochemistry; human western blot; human	Celis J, Gromova I, Cabezon T, Gromov P, Shen T, Timmermans Wielenga V, et al. Identification of a subset of breast carcinomas characterized by expression of cytokeratin 15: relationship between CK15+ progenitor/amplified cells and pre-malignant lesions and invasive disease. Mol Oncol. 2007;1:321-49 pubmed publisher
immunohistochemistry; human; 1:50	Dogu G, Ozkan M, Ozturk F, Dikilitas M, Er O, Ozturk A. Triple-negative breast cancer: immunohistochemical correlation with basaloid markers and prognostic value of survivin. Med Oncol. 2010;27:34-9 pubmed publisher
immunohistochemistry; human	Li J, Gromov P, Gromova I, Moreira J, Timmermans Wielenga V, Rank F, et al. Omics-based profiling of carcinoma of the breast and matched regional lymph node metastasis. Proteomics. 2008;8:5038-52 pubmed publisher
immunohistochemistry; human	Trompetter M, Smedts F, van der Wijk J, Schoots C, de Jong H, Hopman A, et al. Keratin profiling in the developing human prostate. A different approach to understanding epithelial lineage. Anticancer Res. 2008;28:237-43 pubmed
immunohistochemistry; human; 1:50	Laakso M, Tanner M, Nilsson J, Wiklund T, Erikstein B, Kellokumpu Lehtinen P, et al. Basoluminal carcinoma: a new biologically and prognostically distinct entity between basal and luminal breast cancer. Clin Cancer Res. 2006;12:4185-91 pubmed
	Babu S, Mockler D, Roa Peña L, Szygalowicz A, Kim N, Jahanfard S, et al. Keratin 17 is a sensitive and specific biomarker of urothelial neoplasia. Mod Pathol. 2019;32:717-724 pubmed publisher
	Apaydin R, Gurbuz Y, Bayramgurler D, Muezzinoglu B, Bilen N. Cytokeratin expression in lichen amyloidosus and macular amyloidosis. J Eur Acad Dermatol Venereol. 2004;18:305-9 pubmed

image

image 1 :

Formalin-fixed, paraffin-embedded human squamous cell carcinoma stained with Keratin 17 antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.

image 2 :

Formalin-fixed, paraffin-embedded rat breast carcinoma stained with Keratin 17 antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.

image 3 :

product information

Product Type :

Antibody

Product Name :

Cytokeratin 17 Monoclonal Antibody (E3)

Catalog # :

MA5-13539

Quantity :

500 µL

Price :

US 436.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, Rat

Applications :

Immunohistochemistry (Paraffin): 1:40-1:80

Species :

Human, Rat

Clone :

Isotype :

IgG2b, kappa

Storage :

4° C

Description :

Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between approximately40 kDa and approximately68 kDa and isoelectric pH between 4. 9 - 7. 8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Immunogen :

Keratin preparation from rat enterocytes

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:40-1:80

Aliases :

39.1; CK17; CK-17; cytokeratin-17; hard keratin; K17; Ka17; keratin 17; keratin 17, type I; keratin complex 1, acidic, gene 17; keratin, type I cytoskeletal 17; Keratin-17; Krt1-17; Krt17; krt17 {ECO:0000250; PC; PC2; PCHC1; Type I keratin Ka17; UniProtKB:Q04695}

more info or order :

Invitrogen product webpage