p21 Monoclonal Antibody (HJ21 (WA-1)) | Invitrogen MA5-13461 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

p21 Monoclonal Antibody (HJ21 (WA-1))

catalog :

MA5-13461

quantity :

500 µL

price :

US 365

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HJ21 (WA-1)

reactivity :

human, rat

application :

western blot, immunocytochemistry

citations: 11

Reference
Milhollen M, Narayanan U, Soucy T, Veiby P, Smith P, Amidon B. Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover. Cancer Res. 2011;71:3042-51 pubmed publisher
Lin J, Milhollen M, Smith P, Narayanan U, Dutta A. NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells. Cancer Res. 2010;70:10310-20 pubmed publisher
Kawauchi S, Kim J, Santos R, Wu H, Lander A, Calof A. Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11. Development. 2009;136:1453-64 pubmed publisher
Coppock H, Gilham D, Howell A, Clarke R. Cyclin-dependent kinase inhibitors and basement membrane interact to regulate breast epithelial cell differentiation and acinar morphogenesis. Cell Prolif. 2007;40:721-40 pubmed
Koch B, Baul T, Chatterjee A. Cell proliferation inhibition and antitumor activity of novel alkyl series of diorganotin(IV) compounds. J Appl Toxicol. 2008;28:430-8 pubmed
Okano J, Suzuki S, Shiota K. Involvement of apoptotic cell death and cell cycle perturbation in retinoic acid-induced cleft palate in mice. Toxicol Appl Pharmacol. 2007;221:42-56 pubmed
Ray S, Chatterjee A. Influence of endogenous glutathione level on X-ray induced cell cycle delay in human lymphocytes. Cell Prolif. 2006;39:37-47 pubmed
White J, Stead E, Faast R, Conn S, Cartwright P, Dalton S. Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation. Mol Biol Cell. 2005;16:2018-27 pubmed
Cho S, Toouli C, Fujii G, Crain C, Parry D. Chk1 is essential for tumor cell viability following activation of the replication checkpoint. Cell Cycle. 2005;4:131-9 pubmed
Perego P, Gatti L, Righetti S, Beretta G, Carenini N, Corna E, et al. Development of resistance to a trinuclear platinum complex in ovarian carcinoma cells. Int J Cancer. 2003;105:617-24 pubmed
Lu Y, Zi X, Zhao Y, Mascarenhas D, Pollak M. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst. 2001;93:1852-7 pubmed

product information

Product Type :

Antibody

Product Name :

p21 Monoclonal Antibody (HJ21 (WA-1))

Catalog # :

MA5-13461

Quantity :

500 µL

Price :

US 365

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Rat

Applications :

Immunofluorescence: Assay Dependent, Western Blot: 1-2 µg/mL

Species :

Human, Rat

Clone :

HJ21 (WA-1)

Isotype :

IgG1

Storage :

4° C

Description :

Protein p21 is a tumor suppressor protein which is an inhibitor of Cyclin-dependent kinases (CDK) and is transcriptionally activated by p53. P21 is important in the response of cells to genotoxic stress and a major transcriptional target of p53 protein. The occurrence of p21 in the nucleus executes binding and inhibition activity of cyclin dependent kinases Cdk1 and Cdk2, and blocks the transition from G1 phase into S phase or from G2 phase into mitosis after DNA damage, which enables the repair of damaged DNA. In the cytoplasm, p21 protein has an anti-apoptotic effect. P21 is able to bind to and inhibit caspase 3, as well as the apoptotic kinases ASK1 and JNK. P21 exhibits a dual function in carcinogenesis, and acts as a tumor suppressor, prevents apoptosis, and acts as an oncogene.

Immunogen :

Human recombinant p21 protein

Format :

Liquid

Applications w/Dilutions :

Immunofluorescence: Assay Dependent, Western Blot: 1-2 µg/mL

Aliases :

CAP20; cdk inhibitor CIP1 (p21); CDKI; CDK-interacting protein 1; CDK-interaction protein 1; Cdkn1; CDKN1A; CDNK1A; CIP1; cyclin dependent kinase inhibitor 1A; cyclin-dependent kinase inhibitor 1; cyclin-dependent kinase inhibitor 1A; cyclin-dependent kinase inhibitor 1A (P21); cyclin-dependent kinase inhibitor 1A (p21, Cip1); cyclin-dependent kinase inhibitor 1A variant 1; cyclin-dependent kinase inhibitor 1A variant 2; DNA synthesis inhibitor; MDA6; MDA-6; melanoma differentiation associated protein 6; melanoma differentiation-associated protein; Melanoma differentiation-associated protein 6; OTTHUMP00000016298; p21; p21 ; p21CIP1; p21Cip1/Waf1; p21WAF; PIC1; SDI1; UV96; WAF1; wild-type p53-activated fragment 1