SNRPB Monoclonal Antibody (Y12), Biotin | Invitrogen MA5-13446 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SNRPB Monoclonal Antibody (Y12), Biotin

catalog :

MA5-13446

quantity :

500 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

Y12

reactivity :

hamsters, Pacific oyster, human, mouse, rat, pigs , fruit fly , domestic rabbit, roundworm

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 21

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human immunocytochemistry; human	Tsuiji H, Iguchi Y, Furuya A, Kataoka A, Hatsuta H, Atsuta N, et al. Spliceosome integrity is defective in the motor neuron diseases ALS and SMA. EMBO Mol Med. 2013;5:221-34 pubmed publisher
immunocytochemistry; roundworm ; 1:250	Rouhana L, Vieira A, Roberts Galbraith R, Newmark P. PRMT5 and the role of symmetrical dimethylarginine in chromatoid bodies of planarian stem cells. Development. 2012;139:1083-94 pubmed publisher
immunoprecipitation; mouse	Jia Y, Mu J, Ackerman S. Mutation of a U2 snRNA gene causes global disruption of alternative splicing and neurodegeneration. Cell. 2012;148:296-308 pubmed publisher
immunoprecipitation; human	Tanackovic G, Ransijn A, Thibault P, Abou Elela S, Klinck R, Berson E, et al. PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa. Hum Mol Genet. 2011;20:2116-30 pubmed publisher
immunocytochemistry; mouse	Fulka H, Novakova Z, Mosko T, Fulka J. The inability of fully grown germinal vesicle stage oocyte cytoplasm to transcriptionally silence transferred transcribing nuclei. Histochem Cell Biol. 2009;132:457-68 pubmed publisher
immunoprecipitation; human	Kataoka N, Fujita M, Ohno M. Functional association of the Microprocessor complex with the spliceosome. Mol Cell Biol. 2009;29:3243-54 pubmed publisher
immunoprecipitation; mouse western blot; mouse	Gabanella F, Butchbach M, Saieva L, Carissimi C, Burghes A, Pellizzoni L. Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPs. PLoS ONE. 2007;2:e921 pubmed
immunoprecipitation; human	Coady T, Shababi M, Tullis G, Lorson C. Restoration of SMN function: delivery of a trans-splicing RNA re-directs SMN2 pre-mRNA splicing. Mol Ther. 2007;15:1471-8 pubmed
immunohistochemistry; human; 1:100	Comitato A, Spampanato C, Chakarova C, Sanges D, Bhattacharya S, Marigo V. Mutations in splicing factor PRPF3, causing retinal degeneration, form detrimental aggregates in photoreceptor cells. Hum Mol Genet. 2007;16:1699-707 pubmed
immunocytochemistry; human; 1:1000 western blot; human	Almstead L, Sarnow P. Inhibition of U snRNP assembly by a virus-encoded proteinase. Genes Dev. 2007;21:1086-97 pubmed
immunocytochemistry; Pacific oyster	Spada F, Koch J, Sadoni N, Mitchell N, Ganot P, De Boni U, et al. Conserved patterns of nuclear compartmentalization are not observed in the chordate Oikopleura. Biol Cell. 2007;99:273-87 pubmed
immunocytochemistry; fruit fly	Anne J, Ollo R, Ephrussi A, Mechler B. Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila. Development. 2007;134:137-46 pubmed
immunohistochemistry; hamsters	Cameron R, Liu C, Mixon A, Pihkala J, Rahn R, Cameron P. Myosin16b: The COOH-tail region directs localization to the nucleus and overexpression delays S-phase progression. Cell Motil Cytoskeleton. 2007;64:19-48 pubmed
immunoprecipitation; human	Carissimi C, Saieva L, Baccon J, Chiarella P, Maiolica A, Sawyer A, et al. Gemin8 is a novel component of the survival motor neuron complex and functions in small nuclear ribonucleoprotein assembly. J Biol Chem. 2006;281:8126-34 pubmed
immunohistochemistry; mouse	Dehghani H, Reith C, Hahnel A. Subcellular localization of protein kinase C delta and epsilon affects transcriptional and post-transcriptional processes in four-cell mouse embryos. Reproduction. 2005;130:453-65 pubmed
immunocytochemistry; human	Xu H, Somers Z, Robinson M, Hebert M. Tim50a, a nuclear isoform of the mitochondrial Tim50, interacts with proteins involved in snRNP biogenesis. BMC Cell Biol. 2005;6:29 pubmed
immunocytochemistry; mouse western blot; mouse	Krauss S, Lo A, Short S, Koury M, Mohandas N, Chasis J. Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteins. Blood. 2005;106:2200-5 pubmed
	Narayanan U, Achsel T, Luhrmann R, Matera A. Coupled in vitro import of U snRNPs and SMN, the spinal muscular atrophy protein. Mol Cell. 2004;16:223-34 pubmed
	Metz A, Soret J, Vourc h C, Tazi J, Jolly C. A key role for stress-induced satellite III transcripts in the relocalization of splicing factors into nuclear stress granules. J Cell Sci. 2004;117:4551-8 pubmed
	Polak P, Simone F, Kaberlein J, Luo R, Thirman M. ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia. Mol Biol Cell. 2003;14:1517-28 pubmed
	Pu W, Krapivinsky G, Krapivinsky L, Clapham D. pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Mol Cell Biol. 1999;19:4113-20 pubmed

product information

Product Type :

Antibody

Product Name :

SNRPB Monoclonal Antibody (Y12), Biotin

Catalog # :

MA5-13446

Quantity :

500 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Drosophila, Human, Mouse, Porcine, Rabbit, Rat

Applications :

Immunohistochemistry (Paraffin): 1:50-1:100, Immunomicroscopy: Assay-dependent, Western Blot: 1 ug/mL

Species :

Drosophila, Human, Mouse, Porcine, Rabbit, Rat

Clone :

Y12

Isotype :

IgG3, kappa

Storage :

4 C

Description :

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:50-1:100, Immunomicroscopy: Assay-dependent, Western Blot: 1 ug/mL

Aliases :

AL024368; AU018828; B polypeptide of Sm protein; CCMS; COD; sm protein B; Sm protein B/B'; SM11; small nuclear ribonucleoprotein B; small nuclear ribonucleoprotein polypeptide B; small nuclear ribonucleoprotein polypeptides B and B'; small nuclear ribonucleoprotein polypeptides B and B1; small nuclear ribonucleoprotein-associated protein B; Small nuclear ribonucleoprotein-associated proteins B and B'; smB; sm-B; Sm-B/B'; SmB/B'; sm-B/Sm-B'; SmB/SmB'; SNRNP-B; Snrpb; SNRPB1

more info or order :

Invitrogen product webpage