Thrombospondin 1 Monoclonal Antibody (C6.7) | Invitrogen MA5-13390 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Thrombospondin 1 Monoclonal Antibody (C6.7)

catalog :

MA5-13390

quantity :

500 µL

price :

US 496.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

C6.7

reactivity :

human, mouse, rat, dogs, bovine, pigs , domestic sheep, domestic horse

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry, blocking or activating experiments

more info or order :

Invitrogen product webpage

citations: 22

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:500	Aird A, Nevitt C, Christian K, Williams S, Hoying J, LeBlanc A. Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks. Exp Gerontol. 2015;63:18-26 pubmed publisher
western blot; human	Talme T, Bergdahl E, Sundqvist K. Regulation of T-lymphocyte motility, adhesion and de-adhesion by a cell surface mechanism directed by low density lipoprotein receptor-related protein 1 and endogenous thrombospondin-1. Immunology. 2014;142:176-92 pubmed publisher
ELISA; human	Mikuła Pietrasik J, Sosińska P, Janus J, Rubis B, Brewińska Olchowik M, Piwocka K, et al. Bystander senescence in human peritoneal mesothelium and fibroblasts is related to thrombospondin-1-dependent activation of transforming growth factor-?1. Int J Biochem Cell Biol. 2013;45:2087-96 pubmed publisher
blocking or activating experiments; human western blot; human	Bergström S, Bergdahl E, Sundqvist K. A cytokine-controlled mechanism for integrated regulation of T-lymphocyte motility, adhesion and activation. Immunology. 2013;140:441-55 pubmed publisher
blocking or activating experiments; rat	Ikeda H, Miyatake M, Koshikawa N, Ochiai K, Yamada K, Kiss A, et al. Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation. J Biol Chem. 2010;285:38415-27 pubmed publisher
blocking or activating experiments; mouse blocking or activating experiments; human immunocytochemistry; human	Kukreja A, Radfar S, Sun B, Insogna K, Dhodapkar M. Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease. Blood. 2009;114:3413-21 pubmed publisher
blocking or activating experiments; human	Gayen Betal S, Setty B. Phosphatidylserine-positive erythrocytes bind to immobilized and soluble thrombospondin-1 via its heparin-binding domain. Transl Res. 2008;152:165-77 pubmed publisher
ELISA; human	Annis D, Gunderson K, Mosher D. Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations. J Biol Chem. 2007;282:27067-75 pubmed
blocking or activating experiments; human	Marteau F, Gonzalez N, Communi D, Goldman M, Boeynaems J, Communi D. Thrombospondin-1 and indoleamine 2,3-dioxygenase are major targets of extracellular ATP in human dendritic cells. Blood. 2005;106:3860-6 pubmed
blocking or activating experiments; mouse	Rebres R, Kajihara K, Brown E. Novel CD47-dependent intercellular adhesion modulates cell migration. J Cell Physiol. 2005;205:182-93 pubmed
	Jacquemin G, Wurmser A, Huyghe M, Sun W, Homayed Z, Merle C, et al. Paracrine signalling between intestinal epithelial and tumour cells induces a regenerative programme. elife. 2022;11: pubmed publisher
	Beguier F, Housset M, Roubeix C, Augustin S, Zagar Y, Nous C, et al. The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination. Immunity. 2020;53:429-441.e8 pubmed publisher
	Ernens I, Bousquenaud M, Lenoir B, Devaux Y, Wagner D. Adenosine stimulates angiogenesis by up-regulating production of thrombospondin-1 by macrophages. J Leukoc Biol. 2015;97:9-18 pubmed publisher
	Li S, Forslöw A, Sundqvist K. Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction. J Immunol. 2005;174:654-61 pubmed
	Emonard H, Bellon G, Troeberg L, Berton A, Robinet A, Henriet P, et al. Low density lipoprotein receptor-related protein mediates endocytic clearance of pro-MMP-2.TIMP-2 complex through a thrombospondin-independent mechanism. J Biol Chem. 2004;279:54944-51 pubmed
	Doyen V, Rubio M, Braun D, Nakajima T, Abe J, Saito H, et al. Thrombospondin 1 is an autocrine negative regulator of human dendritic cell activation. J Exp Med. 2003;198:1277-83 pubmed
	Lopes N, Gregg D, Vasudevan S, Hassanain H, Goldschmidt Clermont P, Kovacic H. Thrombospondin 2 regulates cell proliferation induced by Rac1 redox-dependent signaling. Mol Cell Biol. 2003;23:5401-8 pubmed
	Smith T, Serghides L, Patel S, Febbraio M, Silverstein R, Kain K. CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum. Infect Immun. 2003;71:393-400 pubmed
	Goel M, Diamond S. Adhesion of normal erythrocytes at depressed venous shear rates to activated neutrophils, activated platelets, and fibrin polymerized from plasma. Blood. 2002;100:3797-803 pubmed
	Li S, Ivanoff A, Bergström S, Sandström A, Christensson B, van Nerven J, et al. T lymphocyte expression of thrombospondin-1 and adhesion to extracellular matrix components. Eur J Immunol. 2002;32:1069-79 pubmed
	Shi S, Cote R, Hawes D, Thu S, Shi Y, Young L, et al. Calcium-induced modification of protein conformation demonstrated by immunohistochemistry: What is the signal?. J Histochem Cytochem. 1999;47:463-70 pubmed
	Gupta K, Gupta P, Solovey A, Hebbel R. Mechanism of interaction of thrombospondin with human endothelium and inhibition of sickle erythrocyte adhesion to human endothelial cells by heparin. Biochim Biophys Acta. 1999;1453:63-73 pubmed

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product information

Product Type :

Antibody

Product Name :

Thrombospondin 1 Monoclonal Antibody (C6.7)

Catalog # :

MA5-13390

Quantity :

500 µL

Price :

US 496.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Canine, Equine, Human, Ovine, Porcine, Rat

Applications :

Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunomicroscopy: Assay-dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL

Species :

Bovine, Canine, Equine, Human, Ovine, Porcine, Rat

Clone :

C6.7

Isotype :

IgG1

Storage :

4° C

Description :

Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

Immunogen :

Ca2+-replete, native purified human TSP from supernatant of thrombin-activated platelets

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent, Immunocytochemistry: Assay-dependent, Immunomicroscopy: Assay-dependent, Immunoprecipitation: 2 µg/mL, Western Blot: 1-2 µg/mL

Aliases :

glycoprotein G; tbsp1; THBS; Thbs1; Thbs-1; thrombospondin; thrombospondin 1; thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1; TSP; TSP1; TSP-1

more info or order :

Invitrogen product webpage