Thrombospondin 1 Monoclonal Antibody (D4.6) | Invitrogen MA5-13385 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Thrombospondin 1 Monoclonal Antibody (D4.6)

catalog :

MA5-13385

quantity :

500 µL

price :

US 500.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

D4.6

reactivity :

human, mouse, rat, dogs, bovine, pigs , domestic sheep, domestic horse

application :

western blot, immunocytochemistry

citations: 24

Reference
Kuroki H, Hayashi H, Nakagawa S, Sakamoto K, Higashi T, Nitta H, et al. Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor Î² signal activation and liver regeneration after hepatectomy in an experimental model. Br J Surg. 2015;102:813-25 pubmed publisher
Daniel C, Vogelbacher R, Stief A, Grigo C, Hugo C. Long-term gene therapy with thrombospondin 2 inhibits TGF-? activation, inflammation and angiogenesis in chronic allograft nephropathy. PLoS ONE. 2013;8:e83846 pubmed publisher
Zhao Y, Wang S, Sorenson C, Teixeira L, Dubielzig R, Peters D, et al. Cyp1b1 mediates periostin regulation of trabecular meshwork development by suppression of oxidative stress. Mol Cell Biol. 2013;33:4225-40 pubmed publisher
Palenski T, Sorenson C, Sheibani N. Inflammatory cytokine-specific alterations in retinal endothelial cell function. Microvasc Res. 2013;89:57-69 pubmed publisher
Narmada B, Chia S, Tucker Kellogg L, Yu H. HGF regulates the activation of TGF-?1 in rat hepatocytes and hepatic stellate cells. J Cell Physiol. 2013;228:393-401 pubmed publisher
Moriya K, Bae E, Honda K, Sakai K, Sakaguchi T, Tsujimoto I, et al. A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodeling. Gastroenterology. 2011;140:1653-63 pubmed publisher
Dews M, Fox J, Hultine S, Sundaram P, Wang W, Liu Y, et al. The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors. Cancer Res. 2010;70:8233-46 pubmed publisher
Ikeda H, Miyatake M, Koshikawa N, Ochiai K, Yamada K, Kiss A, et al. Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation. J Biol Chem. 2010;285:38415-27 pubmed publisher
Hohberg M, Knöchel J, Hoffmann C, Chlench S, Wunderlich W, Alter A, et al. Expression of ADAMTS1 in endothelial cells is induced by shear stress and suppressed in sprouting capillaries. J Cell Physiol. 2011;226:350-61 pubmed publisher
Olsson A, Björk A, Vallon Christersson J, Isaacs J, Leanderson T. Tasquinimod (ABR-215050), a quinoline-3-carboxamide anti-angiogenic agent, modulates the expression of thrombospondin-1 in human prostate tumors. Mol Cancer. 2010;9:107 pubmed publisher
Hyder S, Liang Y, Wu J, Welbern V. Regulation of thrombospondin-1 by natural and synthetic progestins in human breast cancer cells. Endocr Relat Cancer. 2009;16:809-17 pubmed publisher
Hyder S, Liang Y, Wu J. Estrogen regulation of thrombospondin-1 in human breast cancer cells. Int J Cancer. 2009;125:1045-53 pubmed publisher
Rojas A, Meherem S, Kim Y, Washington M, Willis J, Markowitz S, et al. The aberrant methylation of TSP1 suppresses TGF-beta1 activation in colorectal cancer. Int J Cancer. 2008;123:14-21 pubmed publisher
Olerud J, Johansson M, Lawler J, Welsh N, Carlsson P. Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets. Diabetes. 2008;57:1870-7 pubmed publisher
Adams J, Bentley A, Kvansakul M, Hatherley D, Hohenester E. Extracellular matrix retention of thrombospondin 1 is controlled by its conserved C-terminal region. J Cell Sci. 2008;121:784-95 pubmed publisher
Bhattacharyya S, Marinic T, Krukovets I, Hoppe G, Stenina O. Cell type-specific post-transcriptional regulation of production of the potent antiangiogenic and proatherogenic protein thrombospondin-1 by high glucose. J Biol Chem. 2008;283:5699-707 pubmed
Park J, Lee H, Ko K, Park S, Kim J, Choe G, et al. Meteorin regulates angiogenesis at the gliovascular interface. Glia. 2008;56:247-58 pubmed
Derks R, Jankowska Gan E, Xu Q, Burlingham W. Dendritic cell type determines the mechanism of bystander suppression by adaptive T regulatory cells specific for the minor antigen HA-1. J Immunol. 2007;179:3443-51 pubmed
Hong S, Chang S, Yeom D, Kang J, Hong K. Differential regulation of thrombospondin-1 expression and antiangiogenesis of ECV304 cells by trichostatin A and helixor A. Anticancer Drugs. 2007;18:1005-14 pubmed
Gomez Duran A, Mulero Navarro S, Chang X, Fernandez Salguero P. LTBP-1 blockade in dioxin receptor-null mouse embryo fibroblasts decreases TGF-beta activity: Role of extracellular proteases plasmin and elastase. J Cell Biochem. 2006;97:380-92 pubmed
Lo B, Li L, Gissen P, Christensen H, McKiernan P, Ye C, et al. Requirement of VPS33B, a member of the Sec1/Munc18 protein family, in megakaryocyte and platelet alpha-granule biogenesis. Blood. 2005;106:4159-66 pubmed
Cambier S, Gline S, Mu D, Collins R, Araya J, Dolganov G, et al. Integrin alpha(v)beta8-mediated activation of transforming growth factor-beta by perivascular astrocytes: an angiogenic control switch. Am J Pathol. 2005;166:1883-94 pubmed
Olson L, Zhang J, Taylor H, Rose D, Rosenfeld M. Barx2 functions through distinct corepressor classes to regulate hair follicle remodeling. Proc Natl Acad Sci U S A. 2005;102:3708-13 pubmed
Flügel Koch C, Ohlmann A, Piatigorsky J, Tamm E. Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice. Dev Dyn. 2002;225:111-25 pubmed

product information

Product Type :

Antibody

Product Name :

Thrombospondin 1 Monoclonal Antibody (D4.6)

Catalog # :

MA5-13385

Quantity :

500 µL

Price :

US 500.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Canine, Equine, Human, Mouse, Ovine, Porcine, Rat

Applications :

Immunocytochemistry: 2 µg/mL, Immunomicroscopy: Assay-dependent, Western Blot: 1-2 µg/mL

Species :

Bovine, Canine, Equine, Human, Mouse, Ovine, Porcine, Rat

Clone :

D4.6

Isotype :

IgG1

Storage :

4° C

Description :

Thrombospondin is a protein from platelet a-granules. It is made up of three identical subunits bound by interchain disulfides. It is secreted at sites of platelet activation and aggregation and is involved in the processes of chemotaxis, adhesion, proliferation and differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.

Immunogen :

Reduced and alkylated purified human TSP (fully denatured) from the supernatant of thrombin-activated platelets

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2 µg/mL, Immunomicroscopy: Assay-dependent, Western Blot: 1-2 µg/mL

Aliases :

glycoprotein G; tbsp1; THBS; Thbs1; Thbs-1; thrombospondin; thrombospondin 1; thrombospondin-1; thrombospondin-1p180; thrombospondin-p50; ThrombospondinTHBS1; TSP; TSP1; TSP-1