Paxillin Monoclonal Antibody (5H11) | Invitrogen MA5-13356 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Paxillin Monoclonal Antibody (5H11)

catalog :

MA5-13356

quantity :

500 µL

price :

US 496

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5H11

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 14

Reference
Chen D, Sun N, Lu Y, Hong L, Cui T, Wang C, et al. GPR124 facilitates pericyte polarization and migration by regulating the formation of filopodia during ischemic injury. Theranostics. 2019;9:5937-5955 pubmed publisher
Bijian K, Lougheed C, Su J, Xu B, Yu H, Wu J, et al. Targeting focal adhesion turnover in invasive breast cancer cells by the purine derivative reversine. Br J Cancer. 2013;109:2810-8 pubmed publisher
Kandelman J, Waitzberg A, Szejnfeld J, Smith R. Expression of claudin, paxillin and FRA-1 in non-nodular breast lesions in association with microcalcifications. Sao Paulo Med J. 2013;131:71-9 pubmed
Athanasopoulou A, Aroukatos P, Nakas D, Repanti M, Papadaki H, Bravou V. Decreased ezrin and paxillin expression in human urothelial bladder tumors correlate with tumor progression. Urol Oncol. 2013;31:836-42 pubmed publisher
Ozdemir B, Ozdemir A, Colak T, Sezer S, Haberal M. The influence of tubular phenotypic changes on the development of diffuse interstitial fibrosis in renal allografts. Transplant Proc. 2011;43:527-9 pubmed publisher
MacKinnon A, Tretiakova M, Henderson L, Mehta R, Yan B, Joseph L, et al. Paxillin expression and amplification in early lung lesions of high-risk patients, lung adenocarcinoma and metastatic disease. J Clin Pathol. 2011;64:16-24 pubmed publisher
Qi Y, Qu M, Yan Z, Zhao D, Jiang X, Shen B, et al. Cyclic strain modulates migration and proliferation of vascular smooth muscle cells via Rho-GDIalpha, Rac1, and p38 pathway. J Cell Biochem. 2010;109:906-14 pubmed publisher
Yang H, Chen J, Zhang W, Ding Y. Focal adhesion plaque associated cytoskeletons are involved in the invasion and metastasis of human colorectal carcinoma. Cancer Invest. 2010;28:127-34 pubmed publisher
Dai Y, Pierson S, Dudney W, Stack B. Extraribosomal function of metallopanstimulin-1: reducing paxillin in head and neck squamous cell carcinoma and inhibiting tumor growth. Int J Cancer. 2010;126:611-9 pubmed publisher
Wang Y, Yan Z, Shen B, Zhang L, Zhang P, Jiang Z. Vascular smooth muscle cells promote endothelial cell adhesion via microtubule dynamics and activation of paxillin and the extracellular signal-regulated kinase (ERK) pathway in a co-culture system. Eur J Cell Biol. 2009;88:701-9 pubmed publisher
Waschbüsch D, Born S, Niediek V, Kirchgessner N, Tamboli I, Walter J, et al. Presenilin 1 affects focal adhesion site formation and cell force generation via c-Src transcriptional and posttranslational regulation. J Biol Chem. 2009;284:10138-49 pubmed publisher
Short S, Yoder B, Tarr S, Prescott N, Laniauskas S, Coleman K, et al. The expression of the cytoskeletal focal adhesion protein paxillin in breast cancer correlates with HER2 overexpression and may help predict response to chemotherapy: a retrospective immunohistochemical study. Breast J. 2007;13:130-9 pubmed
Takeji M, Moriyama T, Oseto S, Kawada N, Hori M, Imai E, et al. Smooth muscle alpha-actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis. J Biol Chem. 2006;281:40193-200 pubmed
Hirakawa M, Oike M, Karashima Y, Ito Y. Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium. J Physiol. 2004;558:479-88 pubmed

product information

Product Type :

Antibody

Product Name :

Paxillin Monoclonal Antibody (5H11)

Catalog # :

MA5-13356

Quantity :

500 µL

Price :

US 496

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Paraffin): 1-2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 2 µg/mL

Species :

Human, Mouse, Rat

Clone :

5H11

Isotype :

IgG1, kappa

Storage :

4° C

Description :

Paxillin is a focal adhesion protein and a substrate for several tyrosine kinases such as src, FAK, and p210BRC/ABL. The tyrosine phosphorylation of paxillin is affected by conditions that change cell-cell adhesion. Paxillin associates tightly with FAK and Crk through its SH2 domain. This interaction is independent of the extracellular matrix. Although paxillin was initially discovered in fibroblasts, its phosphorylation may also be important during neurite extension during differentiation.

Immunogen :

Purified recombinant full-length human paxillin protein

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry (Paraffin): 1-2 µg/mL, Immunoprecipitation: 2 µg/mL, Western Blot: 2 µg/mL

Aliases :

adaptor protein; AW108311; AW123232; FLJ16691; hCG_1778014; I79_001229; myocardial ischemic preconditioning associated protein 7; Pax; PAX-1; PAXI; Paxillin; paxillin a; paxillin alpha; PXN; pxna; testicular tissue protein Li 134; wu:fw71f12