p21 Monoclonal Antibody (HZ52) | Invitrogen MA5-13293 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

p21 Monoclonal Antibody (HZ52)

catalog :

MA5-13293

quantity :

500µL

price :

US 299

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HZ52

reactivity :

human, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

citations: 13

Reference
Menter T, Ernst M, Drachneris J, Dirnhofer S, Barghorn A, Went P, et al. Phenotype profiling of primary testicular diffuse large B-cell lymphomas. Hematol Oncol. 2014;32:72-81 pubmed publisher
Shilkaitis A, Bratescu L, Green A, Yamada T, Christov K. Bexarotene induces cellular senescence in MMTV-Neu mouse model of mammary carcinogenesis. Cancer Prev Res (Phila). 2013;6:299-308 pubmed publisher
Ozer H, Yenicesu G, Arici S, Cetin M, Tuncer E, Cetin A. Immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in benign, borderline, and malignant serous and mucinous ovarian tumors. Diagn Pathol. 2012;7:124 pubmed publisher
Wolfárd A, Paszt A, Szentpali K, Hideghéthy K, Uhercsak G, Nemeth I, et al. Efficacy and drawbacks of neoadjuvant chemoradiotherapy in squamous cell carcinoma of the thoracic esophagus. Hepatogastroenterology. 2011;58:1214-9 pubmed publisher
Sham C, To K, Chan P, Lee D, Tong M, van Hasselt C. Prevalence of human papillomavirus, Epstein-Barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in Hong Kong patients. Head Neck. 2012;34:520-33 pubmed publisher
Lindström M, Zhang Y. Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation. J Biol Chem. 2008;283:15568-76 pubmed publisher
Brunner A, Verdorfer I, Prelog M, Mayerl C, Mikuz G, Tzankov A. Large-scale analysis of cell cycle regulators in urothelial bladder cancer identifies p16 and p27 as potentially useful prognostic markers. Pathobiology. 2008;75:25-33 pubmed publisher
Zhu Q, Wani G, Yao J, Patnaik S, Wang Q, El Mahdy M, et al. The ubiquitin-proteasome system regulates p53-mediated transcription at p21waf1 promoter. Oncogene. 2007;26:4199-208 pubmed
Ehrlichova M, Koc M, Truksa J, Naldová Z, Vaclavikova R, Kovárr J. Cell death induced by taxanes in breast cancer cells: cytochrome C is released in resistant but not in sensitive cells. Anticancer Res. 2005;25:4215-24 pubmed
Dong M, Guda K, Nambiar P, Nakanishi M, Lichtler A, Nishikawa M, et al. Azoxymethane-induced pre-adipocyte factor 1 (Pref-1) functions as a differentiation inhibitor in colonic epithelial cells. Carcinogenesis. 2004;25:2239-46 pubmed
Bhat K, Itahana K, Jin A, Zhang Y. Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation. EMBO J. 2004;23:2402-12 pubmed
Truksa J, Kovar J, Valenta T, Ehrlichova M, Polak J, Naumann P. Iron deprivation induces apoptosis independently of p53 in human and murine tumour cells. Cell Prolif. 2003;36:199-213 pubmed
Chou Y, Uehara N, Lowry J, Shyamala G. Mammary epithelial cells of PR-A transgenic mice exhibit distinct alterations in gene expression and growth potential associated with transformation. Carcinogenesis. 2003;24:403-9 pubmed

product information

Product Type :

Antibody

Product Name :

p21 Monoclonal Antibody (HZ52)

Catalog # :

MA5-13293

Quantity :

500µL

Price :

US 299

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine, Human, Rat

Applications :

Flow Cytometry: Assay Dependent, Immunocytochemistry: 1:10-1:100, Immunofluorescence: 1:10-1:100, Immunohistochemistry (Paraffin): 2-4 µg/mL, Immunoprecipitation: 2 µg/mg protein lysate, Western Blot: 1:200-1:1000

Species :

Bovine, Human, Rat

Clone :

HZ52

Isotype :

IgG1

Storage :

4° C

Description :

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

Immunogen :

Full length human recombinant p21 protein

Format :

Liquid

Applications w/Dilutions :

Aliases :

CAP20, CDKN1, CDNK1A, MDA-6, SDI1, WAF1, p21CIP1, CDK-interacting protein 1, CDK-interaction protein 1, DNA synthesis inhibitor, cyclin-dependent kinase inhibitor 1, melanoma differentiation associated protein 6, wild-type p53-activated fragment 1