Chromogranin A Monoclonal Antibody (PHE5) | Invitrogen MA5-13281 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Chromogranin A Monoclonal Antibody (PHE5)

catalog :

MA5-13281

quantity :

500 µL

price :

US 370

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PHE5

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:800	Berruti A, Fazio N, Ferrero A, Brizzi M, Volante M, Nobili E, et al. Bevacizumab plus octreotide and metronomic capecitabine in patients with metastatic well-to-moderately differentiated neuroendocrine tumors: the XELBEVOCT study. BMC Cancer. 2014;14:184 pubmed publisher
immunohistochemistry; human; 1:800	Rapa I, Volante M, Migliore C, Farsetti A, Berruti A, Vittorio Scagliotti G, et al. Human ASH-1 promotes neuroendocrine differentiation in androgen deprivation conditions and interferes with androgen responsiveness in prostate cancer cells. Prostate. 2013;73:1241-9 pubmed publisher
immunohistochemistry; human; 1:4000	Hanna J, Reimann J, Haddad R, Krane J. Human papillomavirus-associated adenocarcinoma of the base of the tongue. Hum Pathol. 2013;44:1516-23 pubmed publisher
immunohistochemistry; human; 1:800	Volante M, Daniele L, Asioli S, Cassoni P, Comino A, Coverlizza S, et al. Tumor staging but not grading is associated with adverse clinical outcome in neuroendocrine tumors of the appendix: a retrospective clinical pathologic analysis of 138 cases. Am J Surg Pathol. 2013;37:606-12 pubmed publisher
immunohistochemistry; human; 1:800	Righi L, Rapa I, Votta A, Papotti M, Sapino A. Human achaete-scute homolog-1 expression in neuroendocrine breast carcinoma. Virchows Arch. 2012;460:415-21 pubmed publisher
immunohistochemistry; human; 1:4000	Kraft S, Faquin W, Krane J. HPV-associated neuroendocrine carcinoma of the oropharynx: a rare new entity with potentially aggressive clinical behavior. Am J Surg Pathol. 2012;36:321-30 pubmed publisher
immunohistochemistry; human; 1:300	Mukhopadhyay S, El Zammar O, Katzenstein A. Pulmonary meningothelial-like nodules: new insights into a common but poorly understood entity. Am J Surg Pathol. 2009;33:487-95 pubmed publisher
immunohistochemistry; human	Dilbaz B, Bayoglu Y, Oral S, Cavusoglu D, Uluoglu O, Dilbaz S. Laparoscopic resection of urinary bladder paraganglioma: a case report. Surg Laparosc Endosc Percutan Tech. 2006;16:58-61 pubmed
immunohistochemistry; human; 1:100	Yilmazbayhan D, Ates L, Dilege S, Gulluoglu M, Tanju S, Kalayci G. Pulmonary large cell carcinoma with rhabdoid phenotype. Ann Diagn Pathol. 2005;9:223-6 pubmed
	Deveci M, Deveci G. Altered distribution of metaplastic Paneth, gastrin and pancreatic acinar cells in atrophic gastritic mucosa with endocrine cell lesions. Tohoku J Exp Med. 2004;202:13-22 pubmed
	van Eeden S, Quaedvlieg P, Taal B, Offerhaus G, Lamers C, van Velthuysen M. Classification of low-grade neuroendocrine tumors of midgut and unknown origin. Hum Pathol. 2002;33:1126-32 pubmed

image

image 1 :

Formalin-fixed, paraffin-embedded human GI tumor stained with Chromogranin A antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of tumor cells.

product information

Product Type :

Antibody

Product Name :

Chromogranin A Monoclonal Antibody (PHE5)

Catalog # :

MA5-13281

Quantity :

500 µL

Price :

US 370

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Non-human primate

Applications :

Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): 0.5-1.0 µg/mL

Species :

Human, Non-human primate

Clone :

PHE5

Isotype :

IgG1

Storage :

4° C

Description :

Chromogranin A (CHGA) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocine cells. CHGA is a precursor to three biologically active peptides: vasostatin, pancreastatin, and parastatin. These peptides act as autocine or paracrine negative modulators of the neuroendocrine system. CHGA is an excellent marker for carcinoid tumors, pheo-chromocytomas, paragangliomas, and other neuro-endocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.

Immunogen :

Human pheochromocytoma

Format :

Liquid

Applications w/Dilutions :

Immunofluorescence: Assay Dependent, Immunohistochemistry (Paraffin): 0.5-1.0 µg/mL

Aliases :

AL-11; AL26; Beta-granin; betagranin (N-terminal fragment of chromogranin A); catestatin; CgA; Chga; ChrA; chromofungin; chromogranin A; chromogranin A (parathyroid secretory protein 1); chromogranin A precursor; chromogranin-A; CTNNB; DKFZp686D02253; EA-92; ER-37; ES-43; FLJ25606; FLJ37923; GE-25; GR-44; GV-19; LF-19; MGC105435; Pancreastatin; Parastatin; parathyroid secretory protein 1; p-Glu serpinin precursor; pituitary secretory protein I; Serpinin; Serpinin-RRG; SL21; SP-I; SS-18; Vasostatin I; Vasostatin II; Vasostatin-1; Vasostatin-2; WA-8; WE-14

more info or order :

Invitrogen product webpage